{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:18:55Z","timestamp":1769087935475,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2024-00398053"],"award-info":[{"award-number":["RS-2024-00398053"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["RS-2024-00398053"],"award-info":[{"award-number":["RS-2024-00398053"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>While the efficacy of endovascular thrombectomy (EVT) in large core infarcts has been established, the influence of blood pressure (BP) management on functional outcomes based on infarct volume remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>We conducted a secondary analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy\u2013Optimal Blood Pressure Control (OPTIMAL-BP) trial, which compared intensive (systolic BP\u2009&amp;lt;\u2009140\u2009mmHg) versus conventional (systolic BP 140\u2013180\u2009mmHg) BP management within the first 24\u2009h following successful recanalization. Patients were grouped based on an infarct volume cut-off of 50\u2009ml, assessed 24\u2009h post-EVT. The primary efficacy outcome was functional independence (modified Rankin Scale of 0\u20132) at 3\u2009months. Change of predicted probability for functional independence between BP managements, as infarct volume varied, was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of the 300 patients, 222 (74.0%) were in the infarct volume \u2a7d50\u2009ml group and 78 (26.0%) were in the infarct volume\u2009&amp;gt;50\u2009ml group. The conventional management was significantly associated with a higher rate of functional independence in the infarct volume \u2a7d50\u2009ml group (adjusted odds ratio [AOR], 2.06 [95% CI, 1.12\u20133.86]). In the infarct volume\u2009&amp;gt;50\u2009ml group, the proportion of patients with functional independence was not significantly different between BP managements (AOR, 1.52 [95% CI, 0.46\u20135.04]). The interaction effect between the infarct volume groups and BP managements was not significant. As infarct volume increased, the difference in predicted probability of functional independence between BP managements decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusions:<\/jats:title>\n                    <jats:p>Conventional BP management showed greater benefits for achieving functional independence at 3\u2009months when infarct volumes were smaller. As infarct volume increased, the impact of BP management strategies on functional outcomes decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov (NCT04205305)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251335204","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T02:16:11Z","timestamp":1746238571000},"page":"1281-1291","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood pressure management based on infarct volume after successful endovascular thrombectomy"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-8522","authenticated-orcid":false,"given":"Jae Wook","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"},{"name":"Department of Neurology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaeseob","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"},{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haram","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-2616","authenticated-orcid":false,"given":"Young Dae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-6348","authenticated-orcid":false,"given":"JoonNyung","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yonsei University College of Medicine, Seoul, Korea 4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang-Hoon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Korea University Anam Hospital and College of Medicine, Seoul, Korea 5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Hwan","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chosun University School of Medicine, Gwangju, Korea 6"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungjong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Jin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, Seoul Hospital, Ewha Woman\u2019s University, College of Medicine, Seoul, Korea 7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonkyung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea 8"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyu Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"National Health Insurance Service Ilsan Hospital, Goyang, Korea 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwon-Duk","family":"Seo","sequence":"additional","affiliation":[{"name":"National Health Insurance Service Ilsan Hospital, Goyang, Korea 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kijeong","family":"Lee","sequence":"additional","affiliation":[{"name":"National Health Insurance Service Ilsan Hospital, Goyang, Korea 9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 10"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hwa","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, South Korea 11"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukyoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea 12"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea 13"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Pusan National University School of Medicine, Busan, Korea 14"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hoon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gachon University Gil Medical Center, Incheon, Korea 15"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinkwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea 16"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-6798","authenticated-orcid":false,"given":"Joonsang","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, 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