{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:57:56Z","timestamp":1785463076079,"version":"3.56.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100011235","name":"Independent Order of Odd Fellows","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011235","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100032581","name":"Klinbeforsk","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032581","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Helse S\u00f8r\u2013\u00d8st RHF"},{"name":"Boehringer Ingelheim"},{"DOI":"10.13039\/100011235","name":"Independent Order of Odd Fellows","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032581","name":"Klinbeforsk","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032581","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r\u2013\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale:<\/jats:title>\n                    <jats:p>Central retinal artery occlusion (CRAO) is an ophthalmologic emergency that, without prompt reperfusion, is associated with a high risk of permanent blindness. There is currently no evidence-based, effective treatment for CRAO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and design:<\/jats:title>\n                    <jats:p>TenCRAOS is an investigator-initiated, international, multicenter, randomized controlled, double-dummy, double-blind, phase III trial testing tenecteplase (TNK) 0.25\u2009mg\/kg\u2009+\u2009placebo versus acetylsalicylic acid (ASA) 300\u2009mg\u2009+\u2009placebo. The target population is patients diagnosed with CRAO and a best-corrected visual acuity (BCVA) of \u2a7e1.0 logarithm of the minimum angle of resolution (logMAR), corresponding to a decimal BCVA of \u2a7d0.1 or a fraction BCVA of \u2a7d6\/60, who can be treated within 4.5\u2009h.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Sample size:<\/jats:title>\n                    <jats:p>Assuming a difference in proportion of participants reaching the primary endpoint of 20% in the placebo\/ASA treatment group versus 50% in the TNK\/placebo group, we need 78 participants to reach 80% power to detect the difference on a 5% significance level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcomes:<\/jats:title>\n                    <jats:p>The primary outcome is the proportion of participants with BCVA of \u2a7d0.7\u2009logMAR in the affected eye at 30-day follow-up, corresponding to a decimal BCVA of \u2a7e0.2 or fraction BCVA of \u2a7e6\/30, representing a clinically relevant improvement of BCVA of \u2a7e0.3 logMAR (or 15 letters). Secondary efficacy outcomes include proportion of participants with BCVA of \u2a7d0.5\u2009logMAR, corresponding to a decimal BCVA of \u2a7e0.32 or fraction BCVA of \u2a7e\u20096\/19, self-reported vision-targeted health status, quality of life, and modified Rankin Score at 30 and 90\u2009days. Safety outcomes include symptomatic intracranial hemorrhage, major bleeding, and mortality. Exploratory analyses include assessment with optical coherence tomography with angiography and transorbital ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>TenCRAOS intends to assess the efficacy and safety of systemic TNK within 4.5\u2009h of CRAO onset.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251344199","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T01:09:49Z","timestamp":1749776989000},"page":"1502-1510","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Tenecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): Protocol for a randomized-controlled trial"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5262-4862","authenticated-orcid":false,"given":"Stephen J","family":"Ryan","sequence":"first","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-0653","authenticated-orcid":false,"given":"\u00d8ystein Kalsnes","family":"J\u00f8rstad","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 2"},{"name":"Department of Ophthalmology, Oslo University Hospital, Oslo, Norway 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Skjelland","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Z","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toke","family":"Bek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-9516","authenticated-orcid":false,"given":"Rolf Ankerlund","family":"Blauenfeldt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7292-1971","authenticated-orcid":false,"given":"Petra","family":"Ij\u00e4s","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Hospital, Helsinki, Finland 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arja","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej N.","family":"Khanevski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Haukeland University Hospital, Bergen, Norway 8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-2974","authenticated-orcid":false,"given":"J\u00f8rgen","family":"Krohn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyvind","family":"R\u00f8dahl","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Haukeland University Hospital, Bergen, Norway 9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Department of Neurology, UZ Leuven, Leuven, Belgium 10"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-0237","authenticated-orcid":false,"given":"Jelle","family":"Demeestere","sequence":"additional","affiliation":[{"name":"Department of Neurology, UZ Leuven, Leuven, Belgium 10"},{"name":"Department of Neurosciences, Experimental Neurology, Leuven Brain Institute, KU Leuven, Leuven, Belgium 11"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cassiman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, UZ Leuven, Leuven, Belgium 12"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Nakstad","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vestre Viken Hospital Trust Drammen Hospital, Drammen, Norway 13"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Evensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vestre Viken Hospital Trust Drammen Hospital, Drammen, Norway 13"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiril","family":"Sandell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Drammen Hospital, Drammen, Norway 14"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark 15"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark 16"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-5646","authenticated-orcid":false,"given":"Louisa M","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bispebjerg Hospital Copenhagen, Copenhagen, Denmark 17"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark 16"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"Rosenbaum","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bispebjerg Hospital Copenhagen, Copenhagen, Denmark 17"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-0255","authenticated-orcid":false,"given":"Vaidas","family":"Matijosaitis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital of Lithuanian University of Health Sciences, Kauno Klinikos, Kaunas, Lithuania 18"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda","family":"Zemaitiene","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital of Lithuanian University of Health Sciences, Kauno Klinikos, Kaunas, Lithuania 19"},{"name":"Lithuanian University of Health Sciences, Kaunas, Lithuania 20"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Ellekj\u00e6r","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Medicine, St. Olav University Hospital, Trondheim University Hospital, Trondheim, Norway 21"},{"name":"Department of Neuromedicine and Movement Science, The Norwegian University of Science and Technology, Trondheim, Norway 22"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9782-576X","authenticated-orcid":false,"given":"Dordi","family":"Austeng","sequence":"additional","affiliation":[{"name":"Department of Neuromedicine and Movement Science, The Norwegian University of Science and Technology, Trondheim, Norway 22"},{"name":"Department of Ophthalmology, St. Olav University Hospital, Trondheim University Hospital, Trondheim, Norway 23"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C","family":"Truelsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rigshospitalet, Copenhagen, Denmark 24"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-3506","authenticated-orcid":false,"given":"Michael V","family":"Mazya","sequence":"additional","affiliation":[{"name":"Department of Neurology, Karolinska University Hospital, Stockholm, Sweden 25"},{"name":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden 26"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tr\u00e4isk","sequence":"additional","affiliation":[{"name":"Department of Neuro-Ophthalmology, St Erik Eye Hospital, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden 27"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauli","family":"Ylikotila","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, University of Turku; Neurocenter, Turku University Hospital, Turku, Finland 28"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulpu","family":"Salmi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Turku University Hospital, Turku, Finland 29"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian N","family":"Jenssen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vestfold Hospital Trust, T\u00f8nsberg, Norway 30"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5vard","family":"Lisether","sequence":"additional","affiliation":[{"name":"Department of Neurology, Vestfold Hospital Trust, T\u00f8nsberg, Norway 30"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Breivik","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vestfold Hospital Trust, T\u00f8nsberg, Norway 31"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Devik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nord Tr\u00f8ndelag Trust, Namsos, Norway 32"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse-Marius Sandes","family":"Honningsv\u00e5g","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Nord Tr\u00f8ndelag Trust, Namsos, Norway 33"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgita","family":"Valaikien\u0117","sequence":"additional","affiliation":[{"name":"Center of Neurology, Vilnius University, Vilnius, Lithuania 34"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrius","family":"Cimbalas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania 35"},{"name":"Clinic of Ear, Nose, Throat and Eye Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania 36"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vetle Nilsen","family":"Malmberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Telemark Hospital Trust, Skien, Norway 37"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Espen","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Betanien Hospital, Skien, Norway 38"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"De Raedt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), NEUR Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium 39"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Ten","family":"Tusscher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Brussels, Brussels, Belgium 40"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Ligot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hopital Universitaire Bruxelles, Brussels, Belgium 41"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Lipski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, HUB H\u00f4pital Erasme, Brussels, Belgium 42"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Bj\u00f6rck","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sundsvall Regional Hospital, Sundsvall, Sweden 43"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelie","family":"Hamrin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Sundsvall Regional Hospital, Sundsvall, Sweden 44"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore","family":"Solbakken","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stavanger University Hospital, Stavanger, Norway 45"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane Roushan","family":"Tharaldsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Stavanger University Hospital, Stavanger, Norway 46"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette Huuse","family":"Farmen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway 47"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Helgesen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Innlandet Hospital Trust, Lillehammer, Norway 48"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein Harald","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of North Norway, Troms\u00f8, Norway 49"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir","family":"Bertelsen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of North Norway, Troms\u00f8, Norway 50"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4890-9654","authenticated-orcid":false,"given":"\u00c5se Hagen","family":"Morsund","sequence":"additional","affiliation":[{"name":"Department of Neurology, M\u00f8re and Romsdal Hospital Trust, Molde, Norway 51"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Holen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, M\u00f8re and Romsdal Hospital Trust, Molde, Norway 52"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnstein","family":"Tveiten","sequence":"additional","affiliation":[{"name":"Department of Neurology, S\u00f8rlandet Hospital Trust, Kristiansand, Norway 53"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik B","family":"Johannessen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, S\u00f8rlandet Hospital Trust, Arendal, Norway 54"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-6565","authenticated-orcid":false,"given":"Peter","family":"Kelly","sequence":"additional","affiliation":[{"name":"Mater Misericordiae University Hospital and School of Medicine, University College Dublin, Dublin, Ireland 55"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Dept of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland 56"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansar","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2923-4400","authenticated-orcid":false,"given":"Christina","family":"Kefaloykos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-1579","authenticated-orcid":false,"given":"Thor H\u00e5kon","family":"Skatt\u00f8r","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 2"},{"name":"Department of Radiology, Oslo University Hospital, Oslo, Norway 57"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian L","family":"Kraglund","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Neurology, St. Vincent\u2019s Hospital, Melbourne, Australia 58"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vanacker","sequence":"additional","affiliation":[{"name":"Neurovascular Center and Stroke Unit Antwerp, Antwerp University Hospital, Antwerp, Belgium 59"},{"name":"Department of Neurology, Algemeen Ziekenhuis Groeninge, Kortrijk, Belgium 60"},{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium 61"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9095-2344","authenticated-orcid":false,"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[{"name":"Department of Neurology, Helsinki University Hospital, Helsinki, Finland 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten C","family":"Moe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-2760","authenticated-orcid":false,"given":"Anne Hege","family":"Aamodt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Oslo University Hospital, Oslo, Norway 1"},{"name":"Department of Neuromedicine and Movement Science, The Norwegian University of Science and Technology, Trondheim, Norway 22"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the TenCRAOS Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"2026012115065957100_bibr1-23969873251344199","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1001\/jamaneurol.2015.1578","article-title":"Intravenous fibrinolytic therapy in central retinal artery occlusion: a patient-level meta-analysis","volume":"72","author":"Schrag","year":"2015","journal-title":"JAMA Neurol"},{"key":"2026012115065957100_bibr2-23969873251344199","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ajo.2005.03.038","article-title":"Central retinal artery occlusion: visual outcome","volume":"140","author":"Hayreh","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"2026012115065957100_bibr3-23969873251344199","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.ophtha.2014.04.029","article-title":"Nationwide incidence of clinically diagnosed central retinal artery occlusion in Korea, 2008 to 2011","volume":"121","author":"Park","year":"2014","journal-title":"Ophthalmology"},{"key":"2026012115065957100_bibr4-23969873251344199","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2011.05.005","article-title":"The incidence of central retinal artery occlusion in Olmsted County, Minnesota","volume":"152","author":"Leavitt","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"2026012115065957100_bibr5-23969873251344199","article-title":"Management of central retinal artery occlusion: A Scientific Statement from the American Heart Association","volume":"52","author":"Grory","year":"2021","journal-title":"Stroke"},{"key":"2026012115065957100_bibr6-23969873251344199","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2010.03.061","article-title":"Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial","volume":"117","author":"Schumacher","year":"2010","journal-title":"Ophthalmology"},{"key":"2026012115065957100_bibr7-23969873251344199","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0014-4835(03)00214-8","article-title":"Central retinal artery occlusion. retinal survival time","volume":"78","author":"Hayreh","year":"2004","journal-title":"Exp Eye Res"},{"key":"2026012115065957100_bibr8-23969873251344199","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1161\/STROKEAHA.111.613653","article-title":"Efficacy of intravenous tissue-type plasminogen activator in central retinal artery occlusion: report from a randomized, controlled trial","volume":"42","author":"Chen","year":"2011","journal-title":"Stroke"},{"key":"2026012115065957100_bibr9-23969873251344199","unstructured":"Hughes \u00a0S\n          . Thrombolysis beneficial for \u201ceye stroke\u201d?, https:\/\/www.medscape.com\/viewarticle\/thrombolysis-beneficial-eye-stroke-2024a1000jue?form=fpf (2024)."},{"key":"2026012115065957100_bibr10-23969873251344199","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s13311-023-01391-3","article-title":"Evolving thrombolytics: from Alteplase to Tenecteplase","volume":"20","author":"Miller","year":"2023","journal-title":"Neurotherapeutics"},{"key":"2026012115065957100_bibr11-23969873251344199","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1474-4422(17)30253-3","article-title":"Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial","volume":"16","author":"Logallo","year":"2017","journal-title":"Lancet Neurol"},{"key":"2026012115065957100_bibr12-23969873251344199","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000158","article-title":"Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"49","author":"Powers","year":"2018","journal-title":"Stroke"},{"key":"2026012115065957100_bibr13-23969873251344199","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/23969873221150022","article-title":"European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke","volume":"8","author":"Alamowitch","year":"2023","journal-title":"Eur Stroke J"},{"key":"2026012115065957100_bibr14-23969873251344199","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5693\/djo.02.2023.11.001","article-title":"Thrombolysis in acute retinal ischemia treated with tenecteplase","volume":"30","author":"Kalaga","year":"2024","journal-title":"Digit J Ophthalmol"},{"key":"2026012115065957100_bibr15-23969873251344199","article-title":"Understanding definitions of visual impairment and functional vision","volume":"33","author":"Kv","year":"2020","journal-title":"Community Eye Health"},{"key":"2026012115065957100_bibr16-23969873251344199","article-title":"Oral antiplatelet therapy for acute ischaemic stroke","volume":"2014","author":"Sandercock","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"2026012115065957100_bibr17-23969873251344199","doi-asserted-by":"crossref","first-page":"888456","DOI":"10.3389\/fneur.2022.888456","article-title":"Central retinal artery occlusion: current practice, awareness and prehospital delays in Switzerland","volume":"13","author":"Ardila Jurado","year":"2022","journal-title":"Front Neurol"},{"key":"2026012115065957100_bibr18-23969873251344199","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1001\/jama.2022.19697","article-title":"The International Code of Medical Ethics of the World Medical Association","volume":"328","author":"Parsa-Parsi","year":"2022","journal-title":"JAMA"},{"key":"2026012115065957100_bibr19-23969873251344199","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3928\/1081-597X-19970701-16","article-title":"Proper method for calculating average visual acuity","volume":"13","author":"Holladay","year":"1997","journal-title":"J Refract Surg"},{"key":"2026012115065957100_bibr20-23969873251344199","doi-asserted-by":"crossref","DOI":"10.1177\/2396987321989865","article-title":"European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke","volume":"6","author":"Berge","year":"2021","journal-title":"Eur Stroke J"}],"container-title":["European Stroke Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23969873251344199","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23969873251344199","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/esj\/article-pdf\/10\/4\/1502\/65869243\/23969873251344199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/esj\/article-pdf\/10\/4\/1502\/65869243\/23969873251344199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:08:35Z","timestamp":1769026115000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/esj\/article\/10\/4\/1502\/8377212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1177\/23969873251344199","relation":{},"ISSN":["2396-9873","2396-9881"],"issn-type":[{"value":"2396-9873","type":"print"},{"value":"2396-9881","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12,1]]},"published":{"date-parts":[[2025,12,1]]}}}