{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:22:01Z","timestamp":1791591721456,"version":"4.3.4"},"reference-count":51,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Stroke Journal"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>There are limited data regarding the amyloid positron emission tomography (PET) imaging among patients with Cerebral Amyloid Angiopathy (CAA). We sought to assess the amyloid load distribution detected on amyloid-PET among CAA patients compared to patients with Alzheimer\u2019s Disease (AD), patients with hypertension (HTN) related hemorrhage (ICH) and healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis of published studies with available data on global and regional amyloid-PET uptake was conducted. Comparisons with respect to amyloid load distribution were investigated using random-effects models based on the ratio of mean (RoM) amyloid-PET uptake. RoM\u2009&lt;\u20091 and RoM\u2009&gt;\u20091 indicate lower and higher global or regional amyloid-PET uptake in CAA compared to another population, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We identified 16 cohorts, comprising 271 CAA patients (mean age: 72\u2009years; women: 46%) versus 130 AD patients (mean age: 73\u2009years; women: 44%), 180 patients with HTN-related ICH (mean age: 66\u2009years; women: 36%) and 61 HC (mean age: 71\u2009years; women: 46%) with available data on amyloid-PET. Global amyloid PET ratio differentiated CAA from AD [RoM: 0.93; 95% CI: 0.90\u20130.96;\u2009\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001], HTN-related ICH [RoM: 1.25; 95% CI: 1.20\u20131.31;\u2009\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001], and HC [RoM: 1.26; 95% CI: 1.23\u20131.29;\u2009\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001]. Occipital amyloid-PET uptake [RoM: 1.20; 95% CI: 1.15\u20131.26;\u2009\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001] was higher in CAA compared to HTN-related ICH, and Occipital-to-global [RoM: 1.05; 95% CI: 1.03\u20131.07;\u2009\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001] ratio of amyloid-PET uptake differentiated also CAA from AD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CAA is characterized by a distinct amyloid-PET burden and distribution compared to AD patients, patients with HTN-related ICH and HC. These findings may contribute to the design and conduct of future randomized controlled clinical trials, aiming to treat CAA at preclinical stages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251349657","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T12:17:35Z","timestamp":1750767455000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral amyloid angiopathy and amyloid load distribution detected on amyloid\u2013positron emission tomography: A systematic review and meta-analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7229-2610","authenticated-orcid":false,"given":"Aikaterini","family":"Theodorou","sequence":"first","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3224-3053","authenticated-orcid":false,"given":"Konstantinos","family":"Melanis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Athanasaki","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7757-609X","authenticated-orcid":false,"given":"Lina","family":"Palaiodimou","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Ioanna","family":"Stefanou","sequence":"additional","affiliation":[{"name":"Second Department of Neurology, \u201cAttikon\u201d University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"},{"name":"Department of Neurology &amp; 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