{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:14:05Z","timestamp":1790356445726,"version":"4.1.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Hertie Foundation","award":["ID P1230035"],"award-info":[{"award-number":["ID P1230035"]}]},{"name":"the German Research Foundation","award":["DFG; Emmy Noether grant GZ: GE 3461\/2-1, ID 512461"],"award-info":[{"award-number":["DFG; Emmy Noether grant GZ: GE 3461\/2-1, ID 512461"]}]},{"name":"the German Research Foundation","award":["Munich Cluster for Systems Neurology EXC 2145 SyNe"],"award-info":[{"award-number":["Munich Cluster for Systems Neurology EXC 2145 SyNe"]}]},{"name":"the German Research Foundation DFG under Germany\u2019s Excellence Strategy","award":["EXC-2049 \u2013 390688087"],"award-info":[{"award-number":["EXC-2049 \u2013 390688087"]}]},{"name":"the German Research Foundation DFG under Germany\u2019s Excellence Strategy","award":["KFO-5023 project 2"],"award-info":[{"award-number":["KFO-5023 project 2"]}]},{"name":"F\u00f6FoLe program of LMU Munich","award":["F\u00f6FoLe-Forschungsprojekt Reg.-Nr. 1120"],"award-info":[{"award-number":["F\u00f6FoLe-Forschungsprojekt Reg.-Nr. 1120"]}]},{"name":"the Fritz-Thyssen Foundation","award":["10.22.2.024MN"],"award-info":[{"award-number":["10.22.2.024MN"]}]},{"name":"the German Research Foundation (DFG) as part of the Munich Cluster for Systems Neurology","award":["EXC 2145 SyNergy \u2013 ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy \u2013 ID 390857198"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Stroke Journal"],"abstract":"<jats:sec>\n                    <jats:title>Background and objectives:<\/jats:title>\n                    <jats:p>Anti-inflammatory therapies are tested in randomized trials for secondary stroke prevention. Detecting inflammatory biomarkers that predict vascular recurrence could optimize patient selection for these trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a multicenter prospective cohort study, we measured plasma levels of 22 inflammatory cytokines in 486 acute stroke patients (474 ischemic strokes and 12 intracerebral hemorrhages; median age 68\u2009years, 34% female, median 3\u2009days post-stroke onset). Patients were followed for over 5\u2009years through telephone and in-person interviews to record the occurrence of the following outcomes: (1) recurrent stroke or transient ischemic attack (TIA; primary outcome); (2) a composite of recurrent vascular events (stroke, TIA, acute coronary syndrome, hospital admission due to heart failure, and death; secondary outcome). Associations between cytokine levels and these outcomes were analyzed using Cox proportional hazards models adjusted for demographic and vascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>During the 5-year follow-up period, 59 patients (12.1%) experienced recurrent stroke or TIA, and 118 (24.3%) experienced recurrent vascular events. After adjustments for demographic and vascular risk factors, and correction for multiple comparisons, higher plasma levels of CD62E (adjusted Hazard Ratio (aHR)\/SD increment: 1.63, 95%CI 1.22\u20132.20) and MIF (aHR: 1.56, 95%CI 1.18\u20132.06) in the acute phase after stroke were statistically significantly associated with increased risk of recurrent stroke or TIA. The associations followed a dose-response pattern across quartiles of CD62E and MIF levels. Adding baseline CD62E and MIF levels to models including age, sex, vascular risk factors, and baseline C-reactive protein (CRP) levels led to significant improvements in the prediction of 5-year risk of recurrent stroke or TIA (\u0394C-index 0.030\u20130.050).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among stroke patients, higher baseline levels of CD62E and MIF improved prediction of 5-year risk of recurrent stroke or TIA on top of vascular risk factors and CRP levels. Whether assessment of these cytokines could improve patient selection for secondary prevention trials of anti-inflammatory treatments, should be explored in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251360145","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T04:40:21Z","timestamp":1754973621000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6798-1320","authenticated-orcid":false,"given":"Lanyue","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Ali","family":"Antabi","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Mattar","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar El","family":"Bounkari","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-9407","authenticated-orcid":false,"given":"Rong","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Waegemann","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich, Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-186X","authenticated-orcid":false,"given":"Felix J","family":"Bode","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"},{"name":"Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"St\u00f6sser","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany"},{"name":"Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hermann","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G","family":"Liman","sequence":"additional","affiliation":[{"name":"Center for Stroke Research Berlin (CSB), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany"},{"name":"Department of Neurology, Carl Von Ossietzky University, Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-1775","authenticated-orcid":false,"given":"Christian H","family":"Nolte","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative 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