{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:31:59Z","timestamp":1767699119795,"version":"3.48.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["39\/U\/2017"],"award-info":[{"award-number":["39\/U\/2017"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002943","name":"Departament d\u2019Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021 SGR 00144"],"award-info":[{"award-number":["2021 SGR 00144"]}],"id":[{"id":"10.13039\/501100002943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["European Stroke Journal"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Poor-quality diets promote ischemic stroke. Red blood cell fatty acids (RBC-FAs) are objective, long-term biomarkers of diet. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain, we developed a blood-based lipidomic fat quality (LFQ) score considering pre-defined RBC-FA diet-related biomarkers, and examined whether LFQ score relates to the risk of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:<\/jats:title>\n                    <jats:p>\n                      We determined the RBC-FAs (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009438 cases of incident ischemic stroke,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009438 matched controls). For each participant, we scored 1 for each beneficial metric (C15:0+C17:0; C18:2n-6; C18:3n-3; C20:5n-3; C22:6n-3) \u2a7ethe median of the control group; and 1 for each detrimental metric (C16:0; C16:1n-7; C18:0) &lt;the median of the control group. LFQ score resulted from the 8-component sum (range = 0-8; higher values, higher fat quality). We explored the validity of findings in a different background (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092468 participants from the Framingham Offspring Study without ischemic stroke at baseline, 12-year median follow-up,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009121 cases).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In a fully adjusted model, the Odds Ratio (OR) for ischemic stroke was 0.86 (95% confidence interval [CI]\u2009=\u20090.77\u20130.95) for each 1-unit increase of the LFQ score. Compared to individuals at the lowest category of LFQ score (0\u20133 points), those at the top category (5\u20138 points) had lower odds (OR\u2009=\u20090.64, 95% CI\u2009=\u20090.44\u20130.94). The findings were similar in the Framingham Offspring Study (Hazard Ratio [HR] for each 1-unit increase\u2009=\u20090.83; 95% CI\u2009=\u20090.70\u20130.99; HR for those at top category\u2009=\u20090.49; 95% CI\u2009=\u20090.29\u20130.84, compared to those at the lowest category).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Low blood-based LFQ scores relate to a high risk of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23969873251367250","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:30:48Z","timestamp":1756902648000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a blood-based lipidomic fat quality score for the risk of ischemic stroke"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6172-9845","authenticated-orcid":false,"given":"Iolanda","family":"L\u00e1zaro","sequence":"first","affiliation":[{"name":"Hospital del Mar Medical Research Institute, Barcelona, Spain"},{"name":"Barcelona\u03b2eta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Luj\u00e1n-Barroso","sequence":"additional","affiliation":[{"name":"Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L\u2019Hospitalet de Llobregat, Spain; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program; Bellvitge Biomedical Research Institute - IDIBELL, L\u2019Hospitalet de Llobregat, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Soldevila-Domenech","sequence":"additional","affiliation":[{"name":"Hospital del Mar Medical Research Institute, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio J","family":"Amor","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednic de Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-8905","authenticated-orcid":false,"given":"Emilio","family":"Ortega","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Endocrinology and Nutrition Department, Hospital Cl\u00ednic de Barcelona, Spain"},{"name":"Translational Research in Diabetes, Lipids and Obesity, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Ros","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de la Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Cardiovascular Risk, Nutrition and Aging (IDIBAPS), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Jos\u00e9","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Escuela Andaluza de Salud P\u00fablica (EASP), Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-9779","authenticated-orcid":false,"given":"Miguel","family":"Rodr\u00edguez-Barranco","sequence":"additional","affiliation":[{"name":"Escuela Andaluza de Salud P\u00fablica (EASP), Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, Granada, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dolores","family":"Chirlaque","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Department of Epidemiology, Murcia Region Health Council-IMIB Arrixaca, Murcia, Spain"},{"name":"Division of Preventive Medicine and Public Health, Department of Health and Social Sciences, University of Murcia, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Maria","family":"Huerta","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Department of Epidemiology, Murcia Region Health Council-IMIB Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Guevara","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Instituto de Salud P\u00fablica de Navarra, Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conchi","family":"Moreno-Iribas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), Madrid, Spain"},{"name":"Instituto de Salud P\u00fablica de Navarra, Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Bonet","sequence":"additional","affiliation":[{"name":"Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L\u2019Hospitalet de Llobregat, Spain; 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