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A series of genetic and epidemiological studies have demonstrated that environmental influences play a central role in the onset of systemic sclerosis, while genetic factors determine the susceptibility to and the severity of this disease. Therefore, the identification of predisposing factors related to environmental influences would provide us with an informative clue to better understand the pathological process of this disease. Based on this concept, the deficiency of transcription factor Friend leukemia virus integration 1, which is epigenetically suppressed in systemic sclerosis, seems to be a potential candidate acting as the predisposing factor of this disease. Indeed, Fli1-mutated mice serve as a set of useful disease models to disclose the complex pathology of systemic sclerosis. This article overviews the recent advancement in systemic sclerosis animal models associated with Friend leukemia virus integration 1 deficiency.<\/jats:p>","DOI":"10.1177\/2397198318758221","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T01:24:41Z","timestamp":1522891481000},"page":"6-13","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["What can we learn from\n                    <i>Fli1<\/i>\n                    -deficient mice, new animal models of systemic sclerosis?"],"prefix":"10.1136","volume":"3","author":[{"given":"Yoshihide","family":"Asano","sequence":"first","affiliation":[{"name":"Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo - 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