{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:23:56Z","timestamp":1777983836138,"version":"3.51.4"},"reference-count":20,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Pericardial effusion is a common manifestation of systemic sclerosis, but its pathogenesis has been poorly investigated. Adipokines and interleukins may play a role in the pathophysiology of pericardial effusion. This study aimed at evaluating serum levels of adipokines and interleukins in systemic sclerosis patients with and without pericardial effusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 87 systemic sclerosis patients (age 52.6\u2009\u00b1\u200914\u2009years; disease duration 8.2\u2009\u00b1\u20096.7 years) were recruited in this study. Demographics, body mass index, and clinical characteristics were recorded in each patient. Pericardial effusion was considered pathologic when \u226550\u2009mL was detected by echocardiography. Serum levels of adiponectin, leptin, resistin, visfatin, tumor necrosis factor-\u03b1, interferon-\u03b3, interlueukin-2, interlueukin-10, and interlueukin-17 were measured using Multiplex Immunoassay (Bioplex 200 System).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all, 11 (13%) systemic sclerosis patients had pericardial effusion. Systemic sclerosis patients with and without pericardial effusion did not differ in age, sex, and body mass index. Systemic sclerosis patients with pericardial effusion had significantly higher levels of visfatin (median\/interquartile range: 1546\u2009pg\/mL (interquartile range: 8590) vs 388\u2009pg\/mL (interquartile range: 103), p\u2009=\u20090.03) and interlueukin-17 (1.33\u2009pg\/mL (interquartile range: 3.5) vs 0.05\u2009pg\/mL (interquartile range: 0.56), p\u2009=\u20090.04), but lower levels of adiponectin (2,845,000\u2009pg\/mL (interquartile range: 4,132,900) vs 5,272,100\u2009pg\/mL (interquartile range 8,243,600), p\u2009=\u20090.02) than patients without pericardial effusion. Interstitial lung disease, pulmonary arterial hypertension, and \u201climited\u201d or \u201cdiffuse\u201d cutaneous subset did not correlate to adipokines or interleukin levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Visfatin and adiponectin may play an important role in the pathogenesis of systemic sclerosis\u2013related pericardial effusion. Further longitudinal studies are needed to unravel a possible role of these molecules as biomarkers of pericardial effusion in systemic sclerosis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2397198318762893","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T07:06:13Z","timestamp":1521443173000},"page":"153-158","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Possible role of adipocytokines in systemic sclerosis\u2013associated small pericardial effusion"],"prefix":"10.1136","volume":"3","author":[{"given":"Angela","family":"Chial\u00e0","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Rotondo","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Praino","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorotea","family":"Natuzzi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cacciapaglia","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florenzo","family":"Iannone","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"bibr1-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2012.01755.x"},{"key":"bibr2-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04077.x"},{"key":"bibr3-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.02.003"},{"key":"bibr4-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1007\/s100670170053"},{"key":"bibr5-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070196"},{"key":"bibr6-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1649-2"},{"key":"bibr7-2397198318762893","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket010"},{"issue":"2","key":"bibr8-2397198318762893","first-page":"207","volume":"31","author":"Cantarini 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