{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:26:28Z","timestamp":1790519188604,"version":"4.1.0"},"reference-count":50,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>The potential value of mesenchymal stromal\/stem cell therapy in treating skin fibrosis in scleroderma (systemic sclerosis) and of the caveolin-1 scaffolding domain peptide in treating lung, skin, and heart fibrosis is known. To understand how these observations may relate to differences between mesenchymal stromal\/stem cells from healthy subjects and subjects with fibrosis, we have characterized the fibrogenic and adipogenic potential of adipose-derived mesenchymal stromal\/stem cells from systemic sclerosis patients, from mice with fibrotic lung and skin disease induced by systemic bleomycin treatment, and from healthy controls. Early passage systemic sclerosis adipose-derived mesenchymal stromal\/stem cells have a profibrotic\/anti-adipogenic phenotype compared to healthy adipose-derived mesenchymal stromal\/stem cells (low caveolin-1, high \u03b1-smooth muscle actin, high HSP47, low pAKT, low capacity for adipogenic differentiation). This phenotype is mimicked by treating healthy adipose-derived mesenchymal stromal\/stem cells with transforming growth factor beta or caveolin-1 small interfering RNA and is reversed in systemic sclerosis adipose-derived mesenchymal stromal\/stem cells by treatment with caveolin-1 scaffolding domain peptide, but not scrambled caveolin-1 scaffolding domain peptide. Similar results were obtained with adipose-derived mesenchymal stromal\/stem cells from systemic sclerosis patients and from bleomycin-treated mice, indicating the central role of caveolin-1 in mesenchymal stromal\/stem cell differentiation in fibrotic disease.<\/jats:p>","DOI":"10.1177\/2397198318821510","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T04:36:26Z","timestamp":1548390986000},"page":"127-136","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Adipose-derived mesenchymal stromal\/stem cells in systemic sclerosis: Alterations in function and beneficial effect on lung fibrosis are regulated by caveolin-1"],"prefix":"10.1136","volume":"4","author":[{"given":"Rebecca","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Del Papa","sequence":"additional","affiliation":[{"name":"U.O.C. Day Hospital di Reumatologia, Dipartimento di Reumatologia e Scienze Mediche, ASST Gaetano Pini-CTO, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Introna","sequence":"additional","affiliation":[{"name":"USS Centro di Terapia Cellulare \u201cG. 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Carmen-Lopez","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Helke","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA"},{"name":"Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, 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