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Among various potential factors, exposure to heavy metals, crystalline silica, and organic solvents\u2014acting alone or in combination\u2014can now be considered potential factors in the onset of Klee\u2019s disease. By altering and modulating epigenetic determinants in a genetically susceptible host, these and other environmental factors may have led to perturbations of self-tolerance and inflammation culminating in Klee\u2019s scleroderma.<\/jats:p>","DOI":"10.1177\/2397198320908210","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T07:41:44Z","timestamp":1584344504000},"page":"85-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Was Paul Klee\u2019s scleroderma an occupational disease? 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