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However, new therapeutic options are emerging, and treatment with cyclophosphamide is hampered by its toxicity and restricted possible treatment duration. This review has a focus on the evidence of efficacy of cyclophosphamide in different aspects of systemic sclerosis and its organ involvements, reviews its toxicity, and will answer the question whether there is still a role for cyclophosphamide in the treatment of systemic sclerosis, taking the evidence and current therapeutic options into account.<\/jats:p>","DOI":"10.1177\/2397198320961673","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T02:32:47Z","timestamp":1602037967000},"page":"117-122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Is there still a role for cyclophosphamide in the treatment of systemic sclerosis?"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-9907","authenticated-orcid":false,"given":"Madelon C","family":"Vonk","sequence":"first","affiliation":[{"name":"Department of the Rheumatic Diseases, Radboud 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