{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:03:59Z","timestamp":1781654639844,"version":"3.54.5"},"reference-count":34,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T00:00:00Z","timestamp":1610236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"national institute of arthritis and musculoskeletal and skin diseases","doi-asserted-by":"publisher","award":["K24 AR063120"],"award-info":[{"award-number":["K24 AR063120"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"national institute of arthritis and musculoskeletal and skin diseases","doi-asserted-by":"publisher","award":["R01 AR-07047"],"award-info":[{"award-number":["R01 AR-07047"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Systemic sclerosis\u2013associated interstitial lung disease accounts for up to 20% of mortality in these patients and has a highly variable prognosis. Functional respiratory imaging, a quantitative computed tomography imaging technique which allows mapping of regional information, can provide a detailed view of lung structures. It thereby shows potential to better characterize this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate the use of functional respiratory imaging quantitative computed tomography in systemic sclerosis\u2013associated interstitial lung disease staging, as well as the relationship between short-term changes in pulmonary function tests and functional respiratory imaging quantitative computed tomography with respect to disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>An observational cohort of 35 patients with systemic sclerosis was retrospectively studied by comparing serial pulmonary function tests and in- and expiratory high-resolution computed tomography over 1.5-year interval. After classification into moderate to severe lung disease and limited lung disease (using a hybrid method integrating quantitative computed tomography and pulmonary function tests), post hoc analysis was performed using mixed-effects models and estimated marginal means in terms of functional respiratory imaging parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At follow-up, relative mean forced vital capacity percentage change was not significantly different in the limited (6.37%; N\u2009=\u200913; p\u2009=\u20090.053) and moderate to severe disease (\u22123.54%; N\u2009=\u200916; p\u2009=\u20090.102) groups, respectively. Specific airway resistance decreased from baseline for both groups. (Least square mean changes \u221225.11% predicted ( p\u2009=\u20090.006) and \u221214.02% predicted ( p\u2009=\u20090.001) for limited and moderate to severe diseases.) In contrast to limited disease from baseline, specific airway radius increased in moderate to severe disease by 8.57% predicted ( p\u2009=\u20090.011) with decline of lower lobe volumes of 2.97% predicted ( p\u2009=\u20090.031).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Functional respiratory imaging is able to differentiate moderate to severe disease versus limited disease and to detect disease progression in systemic sclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2397198320985377","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T19:39:09Z","timestamp":1610653149000},"page":"154-164","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Interstitial lung disease in systemic sclerosis quantification of disease classification and progression with high-resolution computed tomography: An observational study"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-8870","authenticated-orcid":false,"given":"Johan","family":"Clukers","sequence":"first","affiliation":[{"name":"Faculty of medicine and health sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lanclus","sequence":"additional","affiliation":[{"name":"FLUIDDA Inc, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Belmans","sequence":"additional","affiliation":[{"name":"FLUIDDA NV, Kontich, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-841X","authenticated-orcid":false,"given":"Cedric","family":"Van Holsbeke","sequence":"additional","affiliation":[{"name":"FLUIDDA NV, Kontich, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"De Backer","sequence":"additional","affiliation":[{"name":"Faculty of medicine and health sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharshan","family":"Vummidi","sequence":"additional","affiliation":[{"name":"Division of Radiology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cronin","sequence":"additional","affiliation":[{"name":"Division of Radiology, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben R","family":"Lavon","sequence":"additional","affiliation":[{"name":"FLUIDDA NV, Kontich, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"De Backer","sequence":"additional","affiliation":[{"name":"FLUIDDA Inc, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Khanna","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, Ann Arbor, MI, 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