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Toxic causes may be involved. We reported the case of a 59-year-old woman who developed an acute systemic sclerosis after two doses of adjuvant chemotherapy by docetaxel and cyclophosphamide for a localized hormone receptor\u2009+\u2009human epithelial receptor 2\u2014breast cancer. Docetaxel is a major chemotherapy drug used in the treatment of breast, lung, and prostate cancers, among others. Scleroderma-like skin-induced changes (morphea) have been already described for taxanes. Here, we report for the first time a case of severe lung and kidney flare with thrombotic microangiopathy after steroids for acute interstitial lung disease probably induced by anti-RNA polymerase III\u2009+\u2009systemic sclerosis after docetaxel.<\/jats:p>","DOI":"10.1177\/23971983211007669","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T02:46:13Z","timestamp":1618368373000},"page":"306-310","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["New-onset systemic sclerosis and scleroderma renal crisis under docetaxel"],"prefix":"10.1136","volume":"6","author":[{"given":"V\u00e9ronique","family":"Debien","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Institut de Canc\u00e9rologie Strasbourg Europe, Strasbourg, 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