{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:58:42Z","timestamp":1787630322297,"version":"build-2736575974"},"reference-count":39,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001003","name":"boehringer ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objectives of this study were to describe the impact of systemic sclerosis associated interstitial lung disease, on quality of life, to estimate the correlation between quality of life and severity of lung disease and to assess the impact of interstitial lung disease on caregivers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seven investigators included systemic sclerosis associated interstitial lung disease patients from December 2019 to April 2020. Sociodemographics and clinical data were collected. Patients reported outcomes and questionnaires were used with 1 generic patients reported outcome (EQ-5D-5L), 1 specific PRO (Brief Interstitial Lung Disease) and 2 self-reported questionnaires on impact of SSc complications and impact on caregivers. The correlation between forced vital capacity and EQ-5D-5L score was estimated with a multivariate linear regression model adjusted on several covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all, 89 patients were included. 26.4% were males, mean age was 58.2 \u00b1 14.5\u2009years. Mean EQ-5D-5L score = 0.79 \u00b1 0.22 (median = 0.85). Mean EQ-5D-5L visual analog scale score = 60.8 \u00b1 20.4 (median = 61.5). Mean King\u2019s Brief Interstitial Lung Disease score = 58.4 \u00b1 12.7 (median = 58.0). After adjustment on covariates, a significant correlation between forced vital capacity and EQ-5D-5L score was found with an increase of 0.003 of the EQ-5D-5L score for a 1% increase of FVC (p = 0.0096). No significant correlation between forced vital capacity and the EQ-VAS and King\u2019s Brief Interstitial Lung Disease score were found. The impact of SSc on other organs was significantly correlated with EQ- 5D-5L score, respectively, for the impact scores on the lung system (p = 0.0003), heart system (p = 0.0182), Raynaud\u2019s syndrome (p = 0.0015), digestive system (p = 0.0032), joints\/muscles (p = 0.0003), skin (p &lt; 0.0001), kidney (p = 0.0052) and gastro-oesophageal reflux (p = 0.0063). Significant correlations between King\u2019s Brief Interstitial Lung Disease score and lung system (p &lt; 0.0001), heart system (p &lt; 0.0001), digital ulcers (p = 0.058), digestive system (p &lt; 0.0001), kidney (p = 0.0004), skin (p = 0.0499) and gastro-oesophageal reflux (p = 0.0033) scores were found 68.5% of patients reported their need for a caregiver to help them in their daily life activities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study highlighted the strong burden of systemic sclerosis associated interstitial lung disease` for patients, especially with an impact on quality of life, on other organs manifestations and need for caregivers in their daily life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983211013979","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T07:28:44Z","timestamp":1624260524000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Quality of life in SSc-ILD patients: Understanding the impact of the ILD and the needs of the SSc-ILD patients and their need for caregivers in France"],"prefix":"10.1136","volume":"7","author":[{"given":"Yannick","family":"Allanore","sequence":"first","affiliation":[{"name":"Rheumatology, Cochin Hospital, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Constans","sequence":"additional","affiliation":[{"name":"Vascular Medicine, CHU Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Godard","sequence":"additional","affiliation":[{"name":"Association des Sclerodermiques de France, Baccon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"de Pouvourville","sequence":"additional","affiliation":[{"name":"ESSEC Business School, Cergy Pontoise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-2680","authenticated-orcid":false,"given":"Stephane","family":"Bouee","sequence":"additional","affiliation":[{"name":"Real World Evidence, CEMKA, Bourg La Reine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Jeanbat","sequence":"additional","affiliation":[{"name":"Real World Evidence, CEMKA, Bourg La Reine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Teissier","sequence":"additional","affiliation":[{"name":"Real World Evidence, CEMKA, Bourg La Reine, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katell","family":"Le Lay","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Chollet","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hachulla","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, Service de M\u00e9decine Interne et Immunologie Clinique, Centre de r\u00e9f\u00e9rence des maladies autoimmunes syst\u00e9miques rares du Nord et Nord-Ouest de France (CeRAINO), U1286\u2013INFINITE\u2013Institute for Translational Research in Inflammation, Lille, 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