{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:17:55Z","timestamp":1780337875277,"version":"3.54.1"},"reference-count":22,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>There is a paucity of real-world data on mycophenolate mofetil\/mycophenolate sodium in systemic sclerosis-related interstitial lung disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To study the efficacy of mycophenolate mofetil\/ mycophenolate sodium in systemic sclerosis-related interstitial lung disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this single-centre study, clinical, laboratory and imaging details of consecutive patients with systemic sclerosis-related interstitial lung disease receiving mycophenolate mofetil\/mycophenolate sodium from rheumatology and pulmonology clinics between January 2008 and March 2017 were retrospectively retrieved. The change in percentage of predicted normal forced vital capacity at last follow-up visit as compared with baseline was studied. In addition, high-resolution computed tomography scans at baseline and 2-year follow-up visit were scored as either stable\/improved or worsened by experienced thoracic radiologists blinded to the clinical details of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Altogether, 88 patients (85.2% females) with mean age (SD) of 33.8\u2009years (\u00b1 11.3) and median (interquartile range) duration of disease since non-Raynaud\u2019s symptoms of 36\u2009months (13.5\u201360) were studied. Diffuse systemic sclerosis comprised 85.2% of them. The mean baseline forced vital capacity was 61.2 \u00b1 17.9% and median scores for ground glass opacities and fibrosis in high-resolution computed tomography were 0.5 (0\u20131.3) and 1 (0\u20131.3), respectively. At a median follow-up duration of 30\u2009months (interquartile range = 16.5\u201349), the percentage of forced vital capacity improved by 1.8% (\u20133.82 to 9.07) as compared with baseline visit ( p = 0.02). In the 2-year follow-up, the ground glass opacity and fibrosis scores in high-resolution computed tomography improved in 17.3% and 7.7% of patients and stabilized in 63.5% and 78.8% patients, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Mycophenolate mofetil\/mycophenolate sodium was efficacious in improving \/stabilizing forced vital capacity irrespective of the baseline high-resolution computed tomography lung scores in our patients with systemic sclerosis-related interstitial lung disease during the \u2a7e 2-year follow-up period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983211024410","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T03:10:07Z","timestamp":1625022607000},"page":"271-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Mycophenolate in scleroderma-associated interstitial lung disease: Real-world data from rheumatology and pulmonology clinics in South Asia"],"prefix":"10.1136","volume":"6","author":[{"given":"Ramya","family":"Janardana","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India"},{"name":"Clinical Immunology & Rheumatology, St. John\u2019s Medical College, Bengaluru, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Irodi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Christian Medical College, Vellore, 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