{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:28:07Z","timestamp":1782156487443,"version":"3.54.5"},"reference-count":8,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>Raynaud\u2019s phenomenon when secondary to underlying systemic disease such as systemic sclerosis occurs early in the disease course and progression can bring significant morbidity such as pain, digital ulceration, and necrosis. Standard medical therapies are aimed at promoting distal arterial vasodilation but are often inadequate in managing Raynaud\u2019s phenomenon. Options for refractory cases include surgical and chemical sympathectomy with Botulinum neurotoxin type A (BoNT\/A) hand injections but the latter can be associated with transient hand weakness. We describe the case of a 35-year-old woman with undifferentiated connective tissue disease, Raynaud\u2019s phenomenon, and concomitant primary focal axillary hyperhidrosis for which she received axillary BoNT\/A therapy every 6\u2009months who noted significant improvement in her Raynaud\u2019s phenomenon and hand arthralgias for 5\u2009months following the axillary injections. This effect remained durable after 24\u2009months of therapy. This improvement in Raynaud\u2019s phenomenon after axillary BoNT\/A has not been previously described.<\/jats:p>","DOI":"10.1177\/23971983211034077","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T02:01:53Z","timestamp":1627610513000},"page":"327-329","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Is axillary botulinum toxin efficient in controlling secondary Raynaud\u2019s phenomenon? A case report"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-3452","authenticated-orcid":false,"given":"David","family":"DeMasters","sequence":"first","affiliation":[{"name":"Wright-Patterson Medical Center, Wright-Patterson AFB, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sturgill","sequence":"additional","affiliation":[{"name":"Wright-Patterson Medical Center, Wright-Patterson AFB, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bartholomew","sequence":"additional","affiliation":[{"name":"Wright-Patterson Medical Center, Wright-Patterson AFB, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"bibr1-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2020.07.009"},{"key":"bibr2-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel280"},{"key":"bibr3-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2010.09.019"},{"key":"bibr4-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04762-4"},{"key":"bibr5-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-011-9738-4"},{"key":"bibr6-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-019-02131-3"},{"key":"bibr7-23971983211034077","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"bibr8-23971983211034077","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S161113"}],"container-title":["Journal of Scleroderma and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23971983211034077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23971983211034077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23971983211034077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:52:52Z","timestamp":1777981972000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23971983211034077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/23971983211034077"],"URL":"https:\/\/doi.org\/10.1177\/23971983211034077","relation":{},"ISSN":["2397-1983","2397-1991"],"issn-type":[{"value":"2397-1983","type":"print"},{"value":"2397-1991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}