{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T16:33:27Z","timestamp":1789317207121,"version":"build-2803163510"},"reference-count":40,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Pulmonary hypertension is one of the leading causes of death in systemic sclerosis. Early detection and treatment of pulmonary hypertension in systemic sclerosis is crucial. Nailfold capillaroscopy microscopy, vascular autoantibodies AT1R and ETAR, and several candidate-biomarkers have the potential to serve as noninvasive tools to identify systemic sclerosis patients at risk for developing pulmonary hypertension. Here, we explore the classifying potential of nailfold capillaroscopy microscopy characteristics and serum levels of selected candidate-biomarkers in a sample of systemic sclerosis patients with and without different forms of pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 81 consecutive systemic sclerosis patients were included, 40 with systemic sclerosis pulmonary hypertension and 41 with no pulmonary hypertension. In each group, quantitative and qualitative nailfold capillaroscopy microscopy characteristics, vascular autoantibodies AT1R and ETAR, and serum levels of 24 soluble serum factors were determined. For evaluation of the nailfold capillaroscopy microscopy characteristics, linear regression analysis accounting for age, sex, and diffusing capacity of the lungs for carbon monoxide percentage predicted was used. Autoantibodies and soluble serum factor levels were compared using two-sample t test with equal variances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>No statistically significant differences were observed in quantitative or qualitative nailfold capillaroscopy microscopy characteristics, or vascular autoantibody ETAR and AT1R titer between systemic sclerosis\u2013pulmonary hypertension and systemic sclerosis\u2013no pulmonary hypertension. In contrast, several serum levels of soluble factors differed between groups: Endostatin, sVCAM, and VEGFD were increased, and CXCL4, sVEGFR2, and PDGF-AB\/BB were decreased in systemic sclerosis\u2013pulmonary hypertension. Random forest classification identified Endostatin and CXCL4 as the most predictive classifiers to distinguish systemic sclerosispulmonary hypertension from systemic sclerosis-no pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study shows the potential for several soluble serum factors to distinguish systemic sclerosis-pulmonary hypertension from systemic sclerosis-no pulmonary hypertension. We found no classifying potential for qualitative or quantitative nailfold capillaroscopy microscopy characteristics, or vascular autoantibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983231175213","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T08:13:17Z","timestamp":1684743197000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-5049","authenticated-orcid":false,"given":"Jacqueline MJ","family":"Lemmers","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan PM","family":"van Caam","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigit","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia HM","family":"van den Ende","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"Knaapen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie PJ","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Hagmolen of ten Have","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank HJ","family":"van den Hoogen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Koenen","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry and Immunology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander I","family":"van Leuven","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wynand","family":"Alkema","sequence":"additional","affiliation":[{"name":"Department of Data Science for Life Sciences & Health, Hanze University, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben L","family":"Smeets","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry and Immunology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-9907","authenticated-orcid":false,"given":"Madelon C","family":"Vonk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"bibr1-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"bibr2-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-3042"},{"key":"bibr3-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13453"},{"key":"bibr4-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1002\/art.21131"},{"key":"bibr5-23971983231175213","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100245"},{"key":"bibr6-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"bibr7-23971983231175213","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.15-6-s58"},{"key":"bibr8-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1002\/art.38029"},{"key":"bibr9-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1002\/art.30541"},{"key":"bibr10-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203301"},{"key":"bibr11-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"bibr12-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00205-2021"},{"key":"bibr13-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.02.006"},{"key":"bibr14-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102458"},{"issue":"2","key":"bibr15-23971983231175213","first-page":"81","volume":"16","author":"Ong YY","year":"1998","journal-title":"Asian Pac J Allergy Immunol"},{"key":"bibr16-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.087353"},{"key":"bibr17-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket168"},{"key":"bibr18-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2204-8"},{"key":"bibr19-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2017.06.005"},{"key":"bibr20-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00088.x"},{"key":"bibr21-23971983231175213","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10071528"},{"key":"bibr22-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2021.101683"},{"key":"bibr23-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.135772"},{"key":"bibr24-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201403-0442OC"},{"issue":"5","key":"bibr25-23971983231175213","first-page":"527","volume":"16","author":"Pignone A","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"bibr26-23971983231175213","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00587"},{"key":"bibr27-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114576"},{"key":"bibr28-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.06.002"},{"key":"bibr29-23971983231175213","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080516"},{"key":"bibr30-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0756-5"},{"key":"bibr31-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1002\/art.40534"},{"key":"bibr32-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012106"},{"key":"bibr33-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102515"},{"key":"bibr34-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"bibr35-23971983231175213","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190296"},{"key":"bibr36-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1775-9"},{"key":"bibr37-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2019-0056OC"},{"key":"bibr38-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02591-2020"},{"key":"bibr39-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09683-z"},{"key":"bibr40-23971983231175213","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.02992.x"}],"container-title":["Journal of Scleroderma and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23971983231175213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23971983231175213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23971983231175213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:52:57Z","timestamp":1777981977000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23971983231175213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/23971983231175213"],"URL":"https:\/\/doi.org\/10.1177\/23971983231175213","relation":{},"ISSN":["2397-1983","2397-1991"],"issn-type":[{"value":"2397-1983","type":"print"},{"value":"2397-1991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}