{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:35:38Z","timestamp":1789961738253,"version":"4.0.1"},"reference-count":29,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of platelet-rich plasma to restore skin changes in morphea by ultrasound and Localized Scleroderma Cutaneous Assessment Tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Nine morphea patients (21 lesions) were diagnosed clinically and by histopathology. Intradermal platelet-rich plasma was injected into morphea lesion once weekly for 12 sessions. The disease severity and damage were evaluated at baseline, after the last session (3\u2009months later), and at 6\u2009months follow-up using the LoSCAT and a high-resolution ultrasound. The healthy corresponding side was considered as a control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The Localized Scleroderma Cutaneous Assessment Tool score showed a significant improvement starting from 13\u2009\u00b1\u20097.28 up to 7.33\u2009\u00b1\u20096.82 after the therapeutic endpoint, reaching to 6.44\u2009\u00b1\u20097.09 after 6\u2009months of follow-up with p value\u2009=\u20090.008 and 0.014, respectively. There was a significant positive correlation between the duration of the lesion and the improvement assessed by the ultrasound, with p value\u2009=\u20090.01. Regarding adverse effects, all patients reported having pain during platelet-rich plasma injection; transient edema of the face was reported by four patients (45%), and only two patients showed transient erythema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Autologous platelet-rich plasma is a safe technique with great aesthetic outcomes for filling up the contour defects and correcting both hyper and hypopigmentation, in addition to softening the indurated lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983231222664","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T02:34:52Z","timestamp":1706063692000},"page":"162-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and ultrasonographic evaluation of efficacy and safety of intralesional injection of autologous platelet-rich plasma in morphea: A comparative case series"],"prefix":"10.1136","volume":"9","author":[{"given":"Esraa","family":"Elnaquip","sequence":"first","affiliation":[{"name":"Dermatology, Andrology & STIs Department, Ras Eltin General Hospital, Alexandria, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Makki","sequence":"additional","affiliation":[{"name":"Dermatology, Andrology & STIs Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofreh","family":"Mansour","sequence":"additional","affiliation":[{"name":"Dermatology, Andrology & STIs Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7291-3616","authenticated-orcid":false,"given":"Abdelhfeez","family":"Moshrif","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"bibr1-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2022.2063841"},{"key":"bibr2-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13572"},{"key":"bibr3-23971983231222664","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S356641"},{"key":"bibr4-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1002\/art.38853"},{"key":"bibr5-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1177\/2397198318799244"},{"key":"bibr6-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.027"},{"key":"bibr7-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-020-04761-8"},{"key":"bibr8-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-02285-x"},{"key":"bibr9-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13300"},{"key":"bibr10-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1007\/s40778-016-0034-8"},{"key":"bibr11-23971983231222664","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20152890"},{"issue":"4","key":"bibr12-23971983231222664","first-page":"650","volume":"35","author":"Arkachaisri 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