{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:43:57Z","timestamp":1790246637222,"version":"4.1.0"},"reference-count":22,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Troponin I has been suggested as a more specific diagnostic biomarker for myocardial involvement in systemic sclerosis than the frequently used troponin T. The aim of this study is to evaluate the additive value of troponin I to detect myocardial involvement in systemic sclerosis. To this end, we evaluated the association between troponin I levels and myocardial involvement in systemic sclerosis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A cross-sectional observational study was performed, including 20 healthy controls and four groups of each 20 systemic sclerosis patients from the Leiden Combined Care in Systemic Sclerosis cohort: (1) patients with myocardial involvement, (2) patients with myositis, (3) patients with elevated troponin T and creatine kinase levels but without organ involvement, and (4) patients without any signs of organ involvement. Troponin I levels were measured using enzyme-linked immunosorbent assay. Troponin I levels were compared between the different groups using the Mann\u2013Whitney U and Kruskal\u2013Wallis tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean age of the 80 included patients was 56\u2009years; 61% of the study population was female. Troponin I levels were not significantly different between patients with and without myocardial involvement (2.7 (0.5\u201315.3) vs 1.2 (0.1\u20136.6) ng\/L; p\u2009=\u20090.117). Systemic sclerosis patients were more often positive for troponin I than healthy controls (70.0% vs 30.0%; p\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Elevated troponin I was not of additional value to diagnose myocardial involvement in systemic sclerosis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983241255550","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:30:32Z","timestamp":1717461032000},"page":"185-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Troponin I levels in systemic sclerosis patients with myocardial involvement"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-6016","authenticated-orcid":false,"given":"Eva M","family":"Hoekstra","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-7062","authenticated-orcid":false,"given":"Sophie IE","family":"Liem","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivine","family":"Levarht","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M","family":"Fehres","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Giuca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Ajmone Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom WJ","family":"Huizinga","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeska K","family":"de Vries-Bouwstra","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"bibr1-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"bibr2-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.010"},{"key":"bibr3-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211448"},{"key":"bibr4-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"bibr5-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834b8975"},{"key":"bibr6-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel312"},{"key":"bibr7-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1177\/23971983211053246"},{"key":"bibr8-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(94)90331-X"},{"key":"bibr9-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000221"},{"key":"bibr10-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90044-8"},{"key":"bibr11-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.042"},{"key":"bibr12-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.016"},{"key":"bibr13-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.1.101"},{"key":"bibr14-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206812"},{"key":"bibr15-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2016.1192217"},{"key":"bibr16-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.072"},{"key":"bibr17-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.10.016"},{"key":"bibr18-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"bibr19-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0903515"},{"key":"bibr20-23971983241255550","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112165"},{"key":"bibr21-23971983241255550","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.07.008"},{"issue":"10","key":"bibr22-23971983241255550","first-page":"1933","volume":"40","author":"Paik 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