{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:11:18Z","timestamp":1793135478616,"version":"4.5.0"},"reference-count":28,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000411","name":"Raynaud\u2019s and Scleroderma Association","doi-asserted-by":"publisher","award":["The Raynaud\u2019s and Scleroderma Association (now S"],"award-info":[{"award-number":["The Raynaud\u2019s and Scleroderma Association (now S"]}],"id":[{"id":"10.13039\/501100000411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Assessment of gastrointestinal and autonomic symptoms in patients with systemic sclerosis, and possible associations with gastric emptying rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Participant and patient disease-related characteristics were collected. Gastrointestinal and autonomic symptoms were assessed by the UCLA-SCTC GIT 2.0 and COMPASS-31 questionnaires, respectively. Potentially confounding gastrointestinal medications were discontinued where possible. Gastric emptying was assessed using a non-radioactive\n                      <jats:sup>13<\/jats:sup>\n                      C sodium acetate isotope, end-expiratory breath samples collected at baseline and then serial timepoints up to 120\u2009min.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In total, 49 participants were studied: 17 with systemic sclerosis with variable gastrointestinal involvement, and healthy matched (n\u2009=\u200917) and non-matched controls (n\u2009=\u200915), the last to control for the impact of age rather than disease on gastric emptying and autonomic function. The total mean (range) UCLA GIT 2.0 questionnaire for patients with systemic sclerosis was 0.63 (0.0\u20131.5) and for both healthy matched and non-matched controls was 0.04 (0.0\u20130.2), and was higher in patients with systemic sclerosis across all domains. The total mean (range) COMPASS-31 score for patients with systemic sclerosis patients was 32.2 (0.0\u201354.9) and for healthy matched- and non-matched controls: 7.45 (0.0\u201324.9) and 4.25 (0.0\u20132.1), respectively, again higher for patients with systemic sclerosis across all domains. No association was observed between patients\u2019 UCLA GIT 2.0 total score (s\u2009=\u2009\u22120.039, p\u2009=\u20090.38), total COMPASS 31 score (s\u2009=\u2009\u22120.108, p\u2009=\u20090.68), or COMPASS-31 GI domain (s\u2009=\u2009\u22120.051, p\u2009=\u20090.85) and gastric emptying rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Gastrointestinal and autonomic symptoms are overrepresented in patients with systemic sclerosis but did not associate with gastric emptying rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983241288039","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T04:07:36Z","timestamp":1729742856000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["An evaluation of autonomic and gastrointestinal symptoms, and gastric emptying, in patients with systemic sclerosis"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3361-4909","authenticated-orcid":false,"given":"Michael","family":"Hughes","sequence":"first","affiliation":[{"name":"Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Harrison","sequence":"additional","affiliation":[{"name":"Shrewsbury and Telford Hospitals NHS Trust, Shrewsbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4941-7926","authenticated-orcid":false,"given":"Ariane L","family":"Herrick","sequence":"additional","affiliation":[{"name":"Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lal","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Manchester, UK"},{"name":"Intestinal Failure Unit, Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"bibr1-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370902"},{"key":"bibr2-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq310"},{"key":"bibr3-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"bibr4-23971983241288039","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2019.80.9.530"},{"key":"bibr5-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1177\/23971983221095763"},{"key":"bibr6-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217035"},{"key":"bibr7-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-00929-1"},{"key":"bibr8-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead486"},{"key":"bibr9-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152419"},{"key":"bibr10-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1002\/acr.25280"},{"key":"bibr11-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130312"},{"key":"bibr12-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24488"},{"key":"bibr13-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead677"},{"key":"bibr14-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90043-B"},{"key":"bibr15-23971983241288039","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170868"},{"key":"bibr16-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1002\/art.34374"},{"key":"bibr17-23971983241288039","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac074"},{"issue":"2","key":"bibr18-23971983241288039","first-page":"202","volume":"15","author":"LeRoy 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