{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:25:51Z","timestamp":1777983951747,"version":"3.51.4"},"reference-count":34,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Interstitial lung disease is the leading cause of morbidity and mortality in systemic sclerosis, but it is characterized by significant heterogeneity in patient outcomes. So far, little is known about the influence of anti-U1RNP antibodies on lung outcomes in systemic sclerosis\u2013associated interstitial lung disease patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>European Scleroderma Trials and Research group systemic sclerosis patients with radiological-confirmed interstitial lung disease, available %predicted forced vital capacity, and autoantibody status were included. Baseline demographic and disease features were compared between anti-U1RNP positive and anti-U1RNP negative patients. Moreover, longitudinal analyses were done measuring relative change in %predicted forced vital capacity over 12\u2009\u00b1\u20096, 24\u2009\u00b1\u20096, and 36\u2009\u00b1\u20096\u2009months, and changes were classified into stable (\u2a7d\u20094%), mild (5%\u20139%), and major progression (\u2a7e\u200910%). Predictors associated with death of any cause or major interstitial lung disease progression were evaluated in systemic sclerosis\u2013associated interstitial lung disease patients with or without anti-U1RNP antibodies. Logistic regression analyses and Cox proportional hazards models adjusted for age and FVC were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 6043 systemic sclerosis\u2013associated interstitial lung disease patients were included for the analysis, among which 327 (5.4%) were positive for anti-U1RNP antibodies. Mean age was 56.8\u2009\u00b1\u200913.2\u2009years and 4971 (82.3%) were women. Anti-U1RNP\u2009+\u2009systemic sclerosis\u2013associated interstitial lung disease patients had more frequently limited cutaneous systemic sclerosis (63.5.5% vs 53.3%, p\u2009&lt;\u20090.001), higher frequency of joint synovitis (18.1% vs 13.9%, p\u2009=\u20090.039), and myositis (24.0% vs 19.5%, p\u2009=\u20090.048). Anti-U1RNP\u2009+\u2009patients had a baseline lower mean forced vital capacity (82.0% vs 86.0%, p\u2009&lt;\u20090.001) and lower mean %predicted diffusing capacity for carbon monoxide (57.0% vs 60.5%, p\u2009=\u20090.003). Periods of mild or major FVC decline and mortality rates were not statistically different between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Systemic sclerosis\u2013associated interstitial lung disease patients positive for anti-U1RNP antibodies have more impaired baseline lung function but similar trajectories of forced vital capacity changes and mortality during the first 3\u2009years of follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983251324827","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T01:59:43Z","timestamp":1742435983000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Interstitial lung disease in anti-U1RNP systemic sclerosis patients: A European Scleroderma Trials and Research analysis"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5891-1868","authenticated-orcid":false,"given":"Gon\u00e7alo","family":"Boleto","sequence":"first","affiliation":[{"name":"Service de Rhumatologie, Cochin Hospital, APHP, Universite Paris Cit\u00e9, Centre de R\u00e9f\u00e9rence Maladies Autoimmunes Syst\u00e9miques Rares d\u2019Ile de France, Paris, France"},{"name":"Department of Rheumatology, ULS Santa Maria, Centro Acad\u00e9mico de Medicina de Lisboa, Lisbon, Portugal; Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-3794","authenticated-orcid":false,"given":"Corrado","family":"Campochiaro","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-8310","authenticated-orcid":false,"given":"Oliver","family":"Distler","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Zurich, University of Zurich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andra","family":"Balanescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, \u201cSf. Maria\u201d Hospital, University of Medicine and Pharmacy \u201cCarol Davila,\u201d Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Launay","sequence":"additional","affiliation":[{"name":"Univ. Lille, Inserm, CHU Lille, U1286\u2014Department of Internal Medicine and Clinical Immunology, INFINITE\u2014Institute for Translational Research in Inflammation, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Clinical Immunology, Friedrich-Alexander-University (FAU) Erlangen-N\u00fcrnberg and Universit\u00e4tsklinikum Erlangen, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Air\u00f2","sequence":"additional","affiliation":[{"name":"Scleroderma Unit, UOC Rheumatology and Clinical Immunology, ASST Spedali Civili, Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahrettin","family":"Oksel","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ege University, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Maria","family":"Gheorghiu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Cantacuzino Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branimir","family":"Anic","sequence":"additional","affiliation":[{"name":"Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, University Hospital Center, Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre de R\u00e9f\u00e9rence Maladies Autoimmunes et Autoinflammatoires Syst\u00e9miques Rares d\u2019Ile de France, de l\u2019Est et de l\u2019Ouest, H\u00f4pital Cochin, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sule","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Marmara, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina-Mihaela","family":"Tanaseanu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Pantelimon Emergency Clinical Hospital, University of Medicine and Pharmacy \u201cCarol Davila,\u201d Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Matucci-Cerinic","sequence":"additional","affiliation":[{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Allanore","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, Cochin Hospital, APHP, Universite Paris Cit\u00e9, Centre de R\u00e9f\u00e9rence Maladies Autoimmunes Syst\u00e9miques Rares d\u2019Ile de France, Paris, France"},{"name":"INSERM U1016 UMR 8104, Universit\u00e9 Paris Cit\u00e9, H\u00f4pital Cochin, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.149"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114264"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2397198320915042"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac660"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02026-2019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2106012"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217455"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062901"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38390"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140006"},{"issue":"2","key":"e_1_3_3_13_2","first-page":"177","article-title":"Gender differences in systemic sclerosis: relationship to clinical features, serologic status and outcomes","volume":"1","author":"Peoples C","year":"2016","unstructured":"Peoples C, Medsger TAJr, Lucas M, et al. 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