{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:22:04Z","timestamp":1777983724612,"version":"3.51.4"},"reference-count":25,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The objective of this investigation was to reveal abnormal musculoskeletal ultrasonographic (US) findings in the hand and wrist joints of systemic sclerosis (SSc) patients compared to healthy controls and to determine the severity of synovitis and tenosynovitis, as well as to disclose the demographic, clinical, and serologic characteristics of patients with SSc with synovitis<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The current study is a cross-sectional study comparing 50 SSc patients and 50 healthy controls between February and September 2023. Metacarpophalangeal (MCP), proximal interphalangeal (PIP), distal interphalangeal (DIP), and wrist joints were evaluated with US.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Synovitis (24 (48%) vs 6 (12%),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001), synovial hypertrophy (19 (38%) vs 1 (2%),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001), tenosynovitis (22 (44%) vs 5 (10%),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001), and calcinosis (7 (14%) vs 0,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.012) were more common in SSc patients than in healthy controls. The presence of osteophytes was also more frequent in SSc patients but not statistically significant (36 (72%) vs 27 (54%),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.062). The frequencies of moderate to severe synovitis and tenosynovitis were similar in the two groups, whereas mild synovitis (44% vs 12%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and tenosynovitis (38% vs 8%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001) were more common in SSc patients. The wrist was the most affected joint. Patients with synovitis had a higher mean age (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.007) and erythrocyte sedimentation rate (ESR;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.025). The presence of high c-reactive protein (CRP;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.039) and hydroxychloroquine use (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.024) were more common in these patients. There was no difference between the frequency of arthralgia in patients with and without synovitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Synovitis, tenosynovitis, and synovial hypertrophy seem to be quite common in SSc patients with or without arthralgia. Patients with synovitis are older, and acute phase markers may be higher in these patients<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983251337227","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:44:08Z","timestamp":1747356248000},"page":"510-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasonographic evaluation of hand and wrist joints in patients with systemic sclerosis"],"prefix":"10.1136","volume":"10","author":[{"given":"Zeynep","family":"Ermanc\u0131k","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5998-6703","authenticated-orcid":false,"given":"M\u00fc\u00e7teba Enes","family":"Yayla","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"\u0130lbay","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilg\u00fcn","family":"G\u00f6ve\u00e7 G\u0131yna\u015f","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u015fk\u0131n","family":"Ate\u015f","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Turgay","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Faculty of Medicine, Ankara University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091165"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.41.2.147"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep250"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-023-06668-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.55730\/1300-0144.5723"},{"issue":"2","key":"e_1_3_2_8_2","first-page":"89","article-title":"Power Doppler ultrasound of the hand and wrist joints in systemic sclerosis","volume":"31","author":"Iagnocco A","year":"2013","unstructured":"Iagnocco A, Vavala C, Vasile M, et al. Power Doppler ultrasound of the hand and wrist joints in systemic sclerosis. Clin Exp Rheumatol 2013; 31(2)(suppl 76): 89\u201395.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2665-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2020.01.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21668"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key214"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2021.04.020"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.136929"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203716"},{"issue":"2","key":"e_1_3_2_17_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, et al. 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