{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:24:33Z","timestamp":1777983873394,"version":"3.51.4"},"reference-count":26,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The study was conducted to investigate the impact of systemic sclerosis (SSc) on hospitalized COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>\n                      This retrospective observational study analyzed data from the National Inpatient Survey (NIS) in 2021. Patients hospitalized with COVID-19 were categorized into SSc and non-SSc groups. Characteristics of patients and comorbidities were compared. The primary outcome was the mortality rate. Secondary outcomes included resource utilization and acute in-hospital complications of SSc. Multivariate logistic regression analyses were conducted, with\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -values\u2009&lt;\u20090.05 considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      Of all, 1865 patients hospitalized with COVID-19 had SSc. Patients with SSc had a higher mortality risk (aOR\u2009=\u20091.37 [1.03\u20131.82];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.032). The average cost of hospitalization was significantly higher in the SSc group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.048), with no difference in LOS (9.4\u2009\u00b1\u20090.65\u2009days vs 8.4\u2009\u00b1\u20090.03\u2009days;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.260). COVID-19 patients with SSc significantly had a higher risk for DIC (aOR 2.82 [1.06\u20137.53];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.038), left-sided HF (aOR 1.76 [1.16\u20132.67];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.008), ventricular arrhythmia (aOR 3.17 [1.01\u20139.89];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.047), oxygen dependence (aOR 2.41 [1.64\u20133.55];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), cardiac arrest (aOR 2.61 [1.63\u20134.18];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and ileus (aOR 2.61 [1.45\u20134.69];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Hospitalized COVID-19 patients with SSc were more likely to develop in-hospital complications and had a higher mortality risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983251342065","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:58:10Z","timestamp":1747727890000},"page":"523-529","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of systemic sclerosis on hospitalized COVID-19 patients: Analysis of the US nationwide inpatient sample (2021)"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3183-7853","authenticated-orcid":false,"given":"Nattanicha","family":"Chaisrimaneepan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Thiravetyan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pannathorn","family":"Nakaphan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Weiss Memorial Hospital, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanokporn","family":"Puchongmart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, 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