{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:21:29Z","timestamp":1788373289883,"version":"build-2803163510"},"reference-count":42,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Scleroderma and Related Disorders"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was undertaken to develop standardized definitions of individual organ system involvement in systemic sclerosis and their date of onset, with the overall goal of increasing the internal validity and comparability of future clinical trials and observational studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Under the auspices of the Scleroderma Clinical Trials Consortium, an international working group of experts and patient partners formed nine sub-groups for each of the following organ systems: skin, peripheral vascular, joints\/tendons, skeletal muscle, gastrointestinal tract, parenchymal lung, pulmonary arterial hypertension, heart, and kidney. Lists of elements that could be considered as potential criteria for involvement of each organ system were compiled. A three-round Delphi exercise was conducted among Scleroderma Clinical Trials Consortium and the European Scleroderma Trials and Research group members in order to achieve consensus with the larger systemic sclerosis community. Informed by the results of the Delphi exercise, sub-groups proposed composite criteria for organ system involvement, and the international working group approved the final criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This consensus-driven project involved over 160 systemic sclerosis experts from around the world, organ system specialists, and patient participants. We developed criteria for nine individual organ systems commonly involved in systemic sclerosis, made recommendations for the date of onset thereof, and provided explanatory notes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We believe these standardized criteria for systemic sclerosis organ system involvement and date of onset provide useful guidelines for investigators and will enhance the comparability of future clinical trials and observational studies in this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/23971983251374385","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T08:44:43Z","timestamp":1758617083000},"page":"293-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Criteria for defining and dating onset of organ system involvement in systemic sclerosis"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6718-2468","authenticated-orcid":false,"given":"Marie","family":"Hudson","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Jewish General Hospital, Lady Davis Institute and McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-2364","authenticated-orcid":false,"given":"John D","family":"Pauling","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, North Bristol NHS Trust, Bristol, UK"},{"name":"Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana S","family":"Rodriguez-Reyna","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8436-1601","authenticated-orcid":false,"given":"Julie J","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-2009","authenticated-orcid":false,"given":"Ami A","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-3840","authenticated-orcid":false,"given":"Tracy M","family":"Frech","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Boin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA"},{"name":"Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, St. Vincent\u2019s Hospital, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Center of Reference for Systemic Autoimmune and Autoinflammatory Diseases of Ile de France, East and West Cochin Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie C","family":"Bani\u00f1a","sequence":"additional","affiliation":[{"name":"Lady Davis Institute, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas A","family":"Medsger","sequence":"additional","affiliation":[{"name":"Division of Rheumatology &amp; 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