{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:09:23Z","timestamp":1777468163422,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Brain and Neuroscience Advances"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Ischaemic stroke presents a significant problem worldwide with no neuroprotective drugs available. Many of the failures in the search for neuroprotectants are attributed to failure to translate from pre-clinical models to humans, which has been combatted with rigorous pre-clinical stroke research guidelines. Here, we present post hoc analysis of a pre-clinical stroke trial, conducted using intraluminal filament transient middle cerebral artery occlusion in the stroke-prone spontaneously hypertensive rat, whereby unscheduled changes were implemented in the animal housing facility. These changes severely impacted body weight post-stroke resulting in a change from the typical body weight of 90.6% of pre-surgery weight post-stroke, to on average 80.5% of pre-surgery weight post-stroke. The changes also appeared to impact post-stroke blood pressure, with an increase from 215.4 to 240.3\u2009mmHg between housing groups, and functional outcome post-stroke, with a 38% increased latency to contact in the sticky label test. These data highlight the importance of tightly controlled housing conditions when using physiological or behavioural measurements as a primary outcome.<\/jats:p>","DOI":"10.1177\/23982128241238934","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T23:28:35Z","timestamp":1710977315000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: A post hoc analysis"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-8330","authenticated-orcid":false,"given":"Aisling","family":"McFall","sequence":"first","affiliation":[{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delyth","family":"Graham","sequence":"additional","affiliation":[{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"Nicklin","sequence":"additional","affiliation":[{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-4109","authenticated-orcid":false,"given":"Lorraine M.","family":"Work","sequence":"additional","affiliation":[{"name":"School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"issue":"5","key":"bibr1-23982128241238934","first-page":"449","volume":"53","author":"Ambery AG","year":"2014","journal-title":"Journal of the American Association for Laboratory Animal Science: JAALAS"},{"key":"bibr2-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.125"},{"key":"bibr3-23982128241238934","first-page":"185","volume":"37","author":"Brauner AE","year":"2010","journal-title":"Scandinavian Journal of Laboratory Animal Science"},{"key":"bibr4-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02043-8"},{"key":"bibr5-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00201.2022"},{"key":"bibr6-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"bibr7-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.541128"},{"key":"bibr8-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00086-5"},{"key":"bibr9-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.7.879"},{"key":"bibr10-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-021-00432-z"},{"key":"bibr11-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000744"},{"key":"bibr12-23982128241238934","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2015.20.1.53"},{"key":"bibr13-23982128241238934","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.36.169"},{"key":"bibr14-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-012-0209-2"},{"key":"bibr15-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6919"},{"issue":"6","key":"bibr16-23982128241238934","first-page":"764","volume":"51","author":"Leys LJ","year":"2012","journal-title":"Journal of the American Association for Laboratory Animal Science: JAALAS"},{"key":"bibr17-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13220"},{"key":"bibr18-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.09.079"},{"key":"bibr19-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110169"},{"key":"bibr20-23982128241238934","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00135"},{"key":"bibr21-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000149629.32525.b7"},{"key":"bibr22-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1038\/s41684-023-01124-1"},{"key":"bibr23-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442"},{"key":"bibr24-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.09.001"},{"key":"bibr25-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.70"},{"key":"bibr26-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1207\/S15327604JAWS0501_5"},{"key":"bibr27-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17709185"},{"key":"bibr28-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.03.060"},{"key":"bibr29-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00796-7"},{"key":"bibr30-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/j.hest.2020.09.001"},{"key":"bibr31-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.04.002"},{"key":"bibr32-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1114-16.2016"},{"key":"bibr33-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.104349"},{"key":"bibr34-23982128241238934","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00168.2023"},{"key":"bibr35-23982128241238934","doi-asserted-by":"publisher","DOI":"10.5665\/SLEEP.1252"}],"container-title":["Brain and Neuroscience Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23982128241238934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/23982128241238934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/23982128241238934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:33:01Z","timestamp":1777383181000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/23982128241238934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"alternative-id":["10.1177\/23982128241238934"],"URL":"https:\/\/doi.org\/10.1177\/23982128241238934","relation":{},"ISSN":["2398-2128","2398-2128"],"issn-type":[{"value":"2398-2128","type":"print"},{"value":"2398-2128","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"23982128241238934"}}