{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:17:22Z","timestamp":1790443042920,"version":"4.1.0"},"reference-count":146,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1K23MH111977"],"award-info":[{"award-number":["1K23MH111977"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["1L30MH111037"],"award-info":[{"award-number":["1L30MH111037"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["5 T32 MH062994 13"],"award-info":[{"award-number":["5 T32 MH062994 13"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Stress"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p> Individuals with obsessive-compulsive disorder often identify psychosocial stress as a factor that exacerbates their symptoms, and many trace the onset of symptoms to a stressful period of life or a discrete traumatic incident. However, the pathophysiological relationship between stress and obsessive-compulsive disorder remains poorly characterized: it is unclear whether trauma or stress is an independent cause of obsessive-compulsive disorder symptoms, a triggering factor that interacts with a preexisting diathesis, or simply a nonspecific factor that can exacerbate obsessive-compulsive disorder along with other aspects of psychiatric symptomatology. Nonetheless, preclinical research has demonstrated that stress has conspicuous effects on corticostriatal and limbic circuitry. Specifically, stress can lead to neuronal atrophy in frontal cortices (particularly the medial prefrontal cortex), the dorsomedial striatum (caudate), and the hippocampus. Stress can also result in neuronal hypertrophy in the dorsolateral striatum (putamen) and amygdala. These neurobiological effects mirror reported neural abnormalities in obsessive-compulsive disorder and may contribute to an imbalance between goal-directed and habitual behavior, an imbalance that is implicated in the pathogenesis and expression of obsessive-compulsive disorder symptomatology. The modulation of corticostriatal and limbic circuits by stress and the resultant imbalance between habit and goal-directed learning and behavior offers a framework for investigating how stress may exacerbate or trigger obsessive-compulsive disorder symptomatology. <\/jats:p>","DOI":"10.1177\/2470547018758043","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T07:23:08Z","timestamp":1520234588000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":100,"title":["The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder"],"prefix":"10.1177","volume":"2","author":[{"given":"Thomas G.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA"},{"name":"Clinical Neuroscience Division, VA National Center for PTSD, West Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kelmendi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA"},{"name":"Clinical Neuroscience Division, VA National Center for PTSD, West Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Alex","family":"Brake","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gruner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christal L.","family":"Badour","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Kentucky, Lexington, KY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Pittenger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA"},{"name":"Clinical Neuroscience Division, VA National Center for PTSD, West Haven, CT, USA"},{"name":"Child Study Center, Yale University, New Haven, CT, USA"},{"name":"Department of Psychology, Yale University, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,3,4]]},"reference":[{"key":"bibr1-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"bibr2-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(78)90022-0"},{"key":"bibr3-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-7967(96)00114-3"},{"key":"bibr4-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.94"},{"key":"bibr5-2470547018758043","volume-title":"World Health Organization Global Program on Evidence of Health Policy, Global Burden of Disease","author":"Ayuso-Mateos JL","year":"2000"},{"key":"bibr6-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.09.008"},{"key":"bibr7-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32436"},{"key":"bibr8-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3746"},{"key":"bibr9-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.011"},{"key":"bibr10-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2014.11.008"},{"key":"bibr11-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-007-9185-9"},{"key":"bibr12-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(99)00090-6"},{"key":"bibr13-2470547018758043","first-page":"109","volume":"37","author":"Ravizza L","year":"1996","journal-title":"Minerva Psichiatrica"},{"key":"bibr14-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1177\/002076408803400408"},{"key":"bibr15-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.2.182"},{"key":"bibr16-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.68.5.748"},{"key":"bibr17-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033408"},{"key":"bibr18-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1037\/10316-000"},{"key":"bibr19-2470547018758043","doi-asserted-by":"crossref","unstructured":"Ingram RE, Luxton DD. Vulnerability-stress models. In: Development of Psychopathology: A Vulnerability-Stress Perspective. Thousand Oaks, CA: Sage; 2005, pp.32\u201346.","DOI":"10.4135\/9781452231655.n2"},{"key":"bibr20-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760290125015"},{"key":"bibr21-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1037\/h0031386"},{"key":"bibr22-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1973.04200010058010"},{"key":"bibr23-2470547018758043","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1972.31.1.235"},{"key":"bibr24-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.143.3.317"},{"key":"bibr25-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/da.20792"},{"key":"bibr26-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.169.1.101"},{"key":"bibr27-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.10.005"},{"key":"bibr28-2470547018758043","first-page":"182","volume":"48","author":"Sarkhel S","year":"2011","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"bibr29-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.144.2.185"},{"key":"bibr30-2470547018758043","first-page":"S49","volume":"57","author":"Hazra SK","year":"2015","journal-title":"Indian J Psychiatry"},{"key":"bibr31-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2009.07.004"},{"key":"bibr32-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199607000-00015"},{"key":"bibr33-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2006.01687.x"},{"key":"bibr34-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5012.194"},{"key":"bibr35-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2006.08.018"},{"key":"bibr36-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-015-0563-x"},{"key":"bibr37-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2017.02.005"},{"key":"bibr38-2470547018758043","first-page":"613","volume-title":"Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment","author":"McKay D","year":"2017"},{"key":"bibr39-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2014.06.009"},{"key":"bibr40-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2010.12.005"},{"key":"bibr41-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.2010.02003.x"},{"key":"bibr42-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024437215004"},{"key":"bibr43-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.843"},{"key":"bibr44-2470547018758043","first-page":"177","volume":"45","author":"Caspi A","year":"2008","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"bibr45-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291711000894"},{"key":"bibr46-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1177\/088626092007002005"},{"key":"bibr47-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/da.10028"},{"key":"bibr48-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.10.021"},{"key":"bibr49-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1159\/000112029"},{"key":"bibr50-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.03.007"},{"key":"bibr51-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1007\/s004060070034"},{"key":"bibr52-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2004.01.001"},{"key":"bibr53-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1177\/2167702613505532"},{"key":"bibr54-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00113-6"},{"key":"bibr55-2470547018758043","first-page":"588","volume-title":"Cingulate Neurobiology and Disease","author":"Saxena S","year":"2009"},{"key":"bibr56-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.09.005"},{"key":"bibr57-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.03.002"},{"key":"bibr58-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.055046"},{"key":"bibr59-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0078"},{"key":"bibr60-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.173"},{"key":"bibr61-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.152"},{"key":"bibr62-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.10.021"},{"key":"bibr63-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.09.005"},{"key":"bibr64-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.8.946"},{"key":"bibr65-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00113-6"},{"key":"bibr66-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1126\/science.1154433"},{"key":"bibr67-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1126\/science.1234733"},{"key":"bibr68-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704547114"},{"key":"bibr69-2470547018758043","first-page":"323","author":"Pittenger C","year":"2017","journal-title":"Obsessive-compulsive Disorder: Phenomenology, Pathophysiology, and Treatment."},{"key":"bibr70-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.178"},{"key":"bibr71-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2015.12.033"},{"key":"bibr72-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10071062"},{"key":"bibr73-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10071062"},{"key":"bibr74-2470547018758043","first-page":"59","volume":"30","author":"Burgui\u00e8re E","year":"2015","journal-title":"SI: Neuropsychiatry"},{"key":"bibr75-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14040525"},{"key":"bibr76-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1177\/1073858414568317"},{"key":"bibr77-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2013.13040574"},{"key":"bibr78-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04218.x"},{"key":"bibr79-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4507-04.2005"},{"key":"bibr80-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1639-09.2009"},{"key":"bibr81-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1088-12.2012"},{"key":"bibr82-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0564-07.2007"},{"key":"bibr83-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3264"},{"key":"bibr84-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22551"},{"key":"bibr85-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.003"},{"key":"bibr86-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22371"},{"key":"bibr87-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2006.02.006"},{"key":"bibr88-2470547018758043","first-page":"728","volume":"47","author":"Simon D","year":"2010","journal-title":"Psychophysiology"},{"key":"bibr89-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2004.06.007"},{"key":"bibr90-2470547018758043","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.559268"},{"key":"bibr91-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(02)00104-X"},{"key":"bibr92-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.4.568"},{"key":"bibr93-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13121700"},{"key":"bibr94-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.038"},{"key":"bibr95-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2648"},{"key":"bibr96-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2008.06.012"},{"key":"bibr97-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.06.010"},{"key":"bibr98-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.05.002"},{"key":"bibr99-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1997.3815"},{"key":"bibr100-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2004.06.008"},{"key":"bibr101-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4806-11.2012"},{"key":"bibr102-2470547018758043","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2011.00059"},{"key":"bibr103-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902690404"},{"key":"bibr104-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-02-00666.2003"},{"key":"bibr105-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3945"},{"key":"bibr106-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.08.001"},{"key":"bibr107-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.06.078"},{"key":"bibr108-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.02.013"},{"key":"bibr109-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807749105"},{"key":"bibr110-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.11.015"},{"key":"bibr111-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.004"},{"key":"bibr112-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180588"},{"key":"bibr113-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0979-09.2009"},{"key":"bibr114-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.59"},{"key":"bibr115-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22174"},{"key":"bibr116-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301574"},{"key":"bibr117-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171203"},{"key":"bibr118-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2012-0049"},{"key":"bibr119-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01459-2"},{"key":"bibr120-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01287-9"},{"key":"bibr121-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1184-06.2006"},{"key":"bibr122-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi104"},{"key":"bibr123-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1549-6"},{"key":"bibr124-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2886"},{"key":"bibr125-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.12.033"},{"key":"bibr126-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4763-10.2011"},{"key":"bibr127-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3090"},{"key":"bibr128-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2016.04.005"},{"key":"bibr129-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.013"},{"key":"bibr130-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.565"},{"key":"bibr131-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.11.022"},{"key":"bibr132-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.12.001"},{"key":"bibr133-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1038\/nrn4038"},{"key":"bibr134-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/13.4.400"},{"key":"bibr135-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2014.10.002"},{"key":"bibr136-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.070"},{"key":"bibr137-2470547018758043","doi-asserted-by":"crossref","unstructured":"Pittenger, C. Animal models of Tourette syndrome and obsessive-compulsive disorder. In: Animal Models of Movement Disorders. Burlington, MA: Elsevier Academic Press; 2014, pp.748\u2013766.","DOI":"10.1016\/B978-0-12-405195-9.00047-0"},{"key":"bibr138-2470547018758043","doi-asserted-by":"crossref","unstructured":"Pittenger C. The neurobiology of tic disorders and obsessive-compulsive disoder: human and animal models. In: Charney DS, Sklar P, Buxbaum JD, Nestler EJ (eds.) Neurobiology of Mental Illness. New York, NY: Oxford University Press; 2017, pp.879\u2013889.","DOI":"10.1093\/med\/9780190681425.003.0065"},{"key":"bibr139-2470547018758043","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00089"},{"key":"bibr140-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2009.0118"},{"key":"bibr141-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1177\/0145445514522056"},{"key":"bibr142-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.10.003"},{"key":"bibr143-2470547018758043","doi-asserted-by":"crossref","unstructured":"Pittenger C. Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions. In: Hattori Y, Seifert R (eds.) Histamine and Histamine Receptors in Health and Disease. Handbook of Experimental Pharmacology. Cham, Switzerland: Springer; 2017, pp.189\u2013215.","DOI":"10.1007\/164_2016_127"},{"key":"bibr144-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.03.067"},{"key":"bibr145-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.02.074"},{"key":"bibr146-2470547018758043","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419533112"}],"container-title":["Chronic Stress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2470547018758043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2470547018758043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2470547018758043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T06:30:44Z","timestamp":1740897044000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/2470547018758043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":146,"alternative-id":["10.1177\/2470547018758043"],"URL":"https:\/\/doi.org\/10.1177\/2470547018758043","relation":{},"ISSN":["2470-5470","2470-5470"],"issn-type":[{"value":"2470-5470","type":"print"},{"value":"2470-5470","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]},"article-number":"2470547018758043"}}