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Specifically, distress disorders are characterized, in part, by heightened sensitivity to underlying motivational systems related to threat\/safety, reward\/loss, or both. Further, individuals suffering from these conditions typically engage in perseverate negative thinking (e.g., worry, rumination, self-criticism) in an effort to manage motivationally relevant distress and often utilize these processes at the detriment of engaging in new contextual learning. Distress disorders are often brought on by enduring chronic stress, coupled with these maladaptive emotional, cognitive, and behavioral responses and ensuing impairment which contribute to and in turn worsen the deficits from these purported mechanisms. Emotion regulation therapy is a theoretically derived treatment that is based upon affective science to offer a blueprint for improving intervention by focusing on targeting the motivational responses and corresponding regulatory failures of individuals with distress disorders. Open and randomized controlled trials have demonstrated considerable preliminary evidence for the utility of emotion regulation therapy and its proposed mechanisms in treating the distress conditions.<\/jats:p>","DOI":"10.1177\/2470547020905787","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T04:32:25Z","timestamp":1581568345000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Emotion Regulation Therapy and Its Potential Role in the Treatment of Chronic Stress-Related Pathology Across Disorders"],"prefix":"10.1177","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-4270","authenticated-orcid":false,"given":"Megan E.","family":"Renna","sequence":"first","affiliation":[{"name":"Institute for Behavioral Medicine Research & Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6736-3912","authenticated-orcid":false,"given":"David M.","family":"Fresco","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Institute for Social Research, University of Michigan, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Mennin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Counseling Psychology, Teachers College, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"bibr1-2470547020905787","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09546.x"},{"key":"bibr2-2470547020905787","doi-asserted-by":"crossref","unstructured":"McEwen BS.\n                      Encyclopedia of Neuroscience. 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