{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:07:04Z","timestamp":1773886024231,"version":"3.50.1"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"crossref","award":["15-1063"],"award-info":[{"award-number":["15-1063"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The A.P. Moeller and Chastine McKinney Moeller Foundation","award":["17-L-0025"],"award-info":[{"award-number":["17-L-0025"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Chronic Stress"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Symptoms of anhedonia are often central to posttraumatic stress disorder (PTSD), but it is unclear how anhedonia is affected by processes induced by reliving past traumatic memories. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Sixty-nine male refugees (PTSD\u2009=\u200938) were interviewed and scanned with functional magnetic resonance imaging while viewing positive, neutral and Scrambled Pictures after being read personalized scripts evoking an emotionally neutral memory and a traumatic memory. We further measured postprovocation state symptoms, physiological measures and PTSD symptoms. We tested whether neural activity associated with positive picture viewing in participants with PTSD was differentially affected by symptom provocation compared to controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> For the pictures\u2009&gt;\u2009scrambled contrast (Positive contrast), PTSD participants had significantly less activity than controls in fusiform gyrus, right inferior temporal gyrus and left middle occipital gyrus. The Positive contrast activity in fusiform gyrus scaled negatively with anhedonia symptoms in PTSD participants after controlling for total PTSD severity. Relative to the emotionally Neutral Script, the Trauma Script decreased positive picture viewing activity in posterior cingulate cortex, precuneus and left calcarine gyrus, but there was no difference between PTSD participants and controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> We found reduced responsiveness of higher visual processing of emotionally positive pictures in PTSD. The significant correlation found between positive picture viewing activity and anhedonia suggests the reduced responsiveness to be due to the severity of anhedonia. <\/jats:p><\/jats:sec>","DOI":"10.1177\/2470547020917623","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T10:31:43Z","timestamp":1588588303000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder \u2013 A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees"],"prefix":"10.1177","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-6008","authenticated-orcid":false,"given":"Sigurd W.","family":"Uldall","sequence":"first","affiliation":[{"name":"Competence Centre for Transcultural Psychiatry (CTP), Mental Health Centre Ballerup, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8606-7641","authenticated-orcid":false,"given":"Kristoffer H.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"},{"name":"Department of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartwig R.","family":"Siebner","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lanius","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, London Health Sciences Centre, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Frewen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, London Health Sciences Centre, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Fischer","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"},{"name":"iMotions, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla G.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Mette","family":"Leffers","sequence":"additional","affiliation":[{"name":"Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egill","family":"Rostrup","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Competence Centre for Transcultural Psychiatry (CTP), Mental Health Centre Ballerup, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayna B.","family":"Nejad","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark"},{"name":"Translational Medicine, Clinical Pharmacology & Translational Medicine, Novo Nordisk A\/S, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"bibr1-2470547020917623","unstructured":"The UN Refugee Agency. 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