{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:06:04Z","timestamp":1788339964535,"version":"build-2803163510"},"reference-count":182,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":1453,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1105857"],"award-info":[{"award-number":["1105857"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1128442"],"award-info":[{"award-number":["1128442"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1177\/2472555218755629","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T08:18:55Z","timestamp":1521533935000},"page":"303-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Amino Acid Transporters as Disease Modifiers and Drug Targets"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8040-1634","authenticated-orcid":false,"given":"Stefan","family":"Br\u00f6er","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1177\/2472555218755629_bib1","series-title":"Amino Acids: Biochemistry and Nutrition","author":"Wu","year":"2013"},{"key":"10.1177\/2472555218755629_bib2","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1042\/BCJ20160822","article-title":"Amino Acid Homeostasis and Signalling in Mammalian Cells and Organisms","volume":"474","author":"Broer","year":"2017","journal-title":"Biochem. J."},{"key":"10.1177\/2472555218755629_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.semcdb.2010.03.002","article-title":"Physiological Role of Autophagy as an Intracellular Recycling System: With an Emphasis on Nutrient Metabolism","volume":"21","author":"Kuma","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1177\/2472555218755629_bib4","doi-asserted-by":"crossref","first-page":"223S","DOI":"10.3945\/ajcn.113.070086","article-title":"Role of Amino Acid Transporters in Amino Acid Sensing","volume":"99","author":"Taylor","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1177\/2472555218755629_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/BJ20101912","article-title":"The Role of Amino Acid Transporters in Inherited and Acquired Diseases","volume":"436","author":"Broer","year":"2011","journal-title":"Biochem. J."},{"key":"10.1177\/2472555218755629_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fchem.2014.00061","article-title":"Membrane Transporters for the Special Amino Acid Glutamine: Structure\/Function Relationships and Relevance to Human Health","volume":"2","author":"Pochini","year":"2014","journal-title":"Front. Chem."},{"key":"10.1177\/2472555218755629_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/18744672113069990033","article-title":"SLC1 Glutamate Transporters and Diseases: Psychiatric Diseases and Pathological Pain","volume":"6","author":"Nakagawa","year":"2013","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1177\/2472555218755629_bib8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tips.2014.05.006","article-title":"Glycine Transport Inhibitors for the Treatment of Pain","volume":"35","author":"Vandenberg","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1177\/2472555218755629_bib9","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nrd3893","article-title":"Glycine Transporters as Novel Therapeutic Targets in Schizophrenia, Alcohol Dependence and Pain","volume":"12","author":"Harvey","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1177\/2472555218755629_bib10","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1158\/0008-5472.CAN-14-3745","article-title":"Amino Acid Transporters in Cancer and Their Relevance to \u201cGlutamine Addiction\u201d: Novel Targets for the Design of a New Class of Anticancer Drugs","volume":"75","author":"Bhutia","year":"2015","journal-title":"Cancer Res."},{"key":"10.1177\/2472555218755629_bib11","first-page":"1281","article-title":"L-Type Amino Acid Transport and Cancer: Targeting the mTORC1 Pathway to Inhibit Neoplasia","volume":"5","author":"Wang","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1177\/2472555218755629_bib12","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1349-7006.2009.01386.x","article-title":"L-Type Amino Acid Transporter 1 Inhibitors Inhibit Tumor Cell Growth","volume":"101","author":"Oda","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1177\/2472555218755629_bib13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molmet.2015.02.003","article-title":"Mice Lacking Neutral Amino Acid Transporter B(0)AT1 (Slc6a19) Have Elevated Levels of FGF21 and GLP-1 and Improved Glycaemic Control","volume":"4","author":"Jiang","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1177\/2472555218755629_bib14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2009.03.018","article-title":"Glycine Transporter Inhibitors as a Novel Drug Discovery Strategy for Neuropathic Pain","volume":"123","author":"Dohi","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1177\/2472555218755629_bib15","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1007\/s11064-017-2317-6","article-title":"An L-Glutamine Transporter Isoform for Neurogenesis Facilitated by L-Theanine","volume":"42","author":"Yoneda","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1177\/2472555218755629_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mod.2016.06.003","article-title":"Regulation of Amino Acid Transporters in Pluripotent Cell Populations in the Embryo and in Culture; Novel Roles for Sodium-Coupled Neutral Amino Acid Transporters","volume":"141","author":"Tan","year":"2016","journal-title":"Mech. Dev."},{"key":"10.1177\/2472555218755629_bib17","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/hepr.12069","article-title":"Sodium-Coupled Neutral Amino Acid Transporter 4 Functions as a Regulator of Protein Synthesis during Liver Development","volume":"43","author":"Kondou","year":"2013","journal-title":"Hepatol. Res."},{"key":"10.1177\/2472555218755629_bib18","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1095\/biolreprod.109.081646","article-title":"Rescue of Postcompaction-Stage Mouse Embryo Development from Hypertonicity by Amino Acid Transporter Substrates That May Function as Organic Osmolytes","volume":"82","author":"Richards","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1177\/2472555218755629_bib19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/humupd\/dmp045","article-title":"Cell Volume Regulation in Oocytes and Early Embryos: Connecting Physiology to Successful Culture Media","volume":"16","author":"Baltz","year":"2010","journal-title":"Hum. Reprod. Update"},{"key":"10.1177\/2472555218755629_bib20","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1242\/dev.026575","article-title":"SIT1 Is a Betaine\/Proline Transporter That Is Activated in Mouse Eggs after Fertilization and Functions until the 2-Cell Stage","volume":"135","author":"Anas","year":"2008","journal-title":"Development"},{"key":"10.1177\/2472555218755629_bib21","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.cmet.2017.05.011","article-title":"Interrupted Glucagon Signaling Reveals Hepatic Alpha Cell Axis and Role for L-Glutamine in Alpha Cell Proliferation","volume":"25","author":"Dean","year":"2017","journal-title":"Cell Metab."},{"key":"10.1177\/2472555218755629_bib22","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cmet.2017.05.006","article-title":"Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic Alpha Cell Hyperplasia in Mice","volume":"25","author":"Kim","year":"2017","journal-title":"Cell Metab."},{"key":"10.1177\/2472555218755629_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane Transporters in Drug Development","volume":"9","author":"Giacomini","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1177\/2472555218755629_bib24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/17460441.2017.1253676","article-title":"New Experimental Models of the Blood-Brain Barrier for CNS Drug Discovery","volume":"12","author":"Kaisar","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1177\/2472555218755629_bib25","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7378.1","article-title":"The Biological Significance of Brain Barrier Mechanisms: Help or Hindrance in Drug Delivery to the Central Nervous System?","volume":"5","author":"Saunders","year":"2016","journal-title":"F1000Res"},{"key":"10.1177\/2472555218755629_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From Blood-Brain Barrier to Blood-Brain Interface: New Opportunities for CNS Drug Delivery","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1177\/2472555218755629_bib27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fphar.2015.00208","article-title":"Insights to Ligand Binding to the Monoamine Transporters\u2014From Homology Modeling to LeuBAT and dDAT","volume":"6","author":"Koldso","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1177\/2472555218755629_bib28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0968-0896(98)00247-8","article-title":"Conformational Aspects of Inhibitor Design: Enzyme-Substrate Interactions in the Transition State","volume":"7","author":"Wolfenden","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1177\/2472555218755629_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0005-2728(94)90189-9","article-title":"Functional Principles of Solute Transport Systems: Concepts and Perspectives","volume":"1185","author":"Kramer","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/2472555218755629_bib30","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1016\/j.jmb.2017.07.009","article-title":"A Glimpse of Membrane Transport through Structures\u2014Advances in the Structural Biology of the GLUT Glucose Transporters","volume":"429","author":"Yan","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1177\/2472555218755629_bib31","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1073\/pnas.1324141111","article-title":"Structure of Sugar-Bound LacY","volume":"111","author":"Kumar","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib32","doi-asserted-by":"crossref","first-page":"12486","DOI":"10.1073\/pnas.1300772110","article-title":"Induced Fit Substrate Binding to an Archeal Glutamate Transporter Homologue","volume":"110","author":"Ewers","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbabio.2010.10.014","article-title":"The Structural Basis of Secondary Active Transport Mechanisms","volume":"1807","author":"Forrest","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/2472555218755629_bib34","series-title":"Amino Acids, Peptides and Proteins in Organic Synthesis","first-page":"151","article-title":"Medicinal Chemistry of \u03b1-Amino Acids","author":"Krogsgaard-Larsen","year":"2011"},{"key":"10.1177\/2472555218755629_bib35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mam.2013.01.001","article-title":"The SLC1 High-Affinity Glutamate and Neutral Amino Acid Transporter Family","volume":"34","author":"Kanai","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1177\/2472555218755629_bib36","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature22064","article-title":"Structure and Allosteric Inhibition of Excitatory Amino Acid Transporter 1","volume":"544","author":"Canul-Tec","year":"2017","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib37","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/jm8013458","article-title":"Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1","volume":"52","author":"Jensen","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1177\/2472555218755629_bib38","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1021\/acs.jmedchem.7b00924","article-title":"Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine\/Gamma-Aminobutyric Acid Transporter 1 (BGT1)","volume":"60","author":"Jorgensen","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1177\/2472555218755629_bib39","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.toxicon.2011.07.012","article-title":"Discovery and Development of the Chi-Conopeptide Class of Analgesic Peptides","volume":"59","author":"Lewis","year":"2012","journal-title":"Toxicon"},{"key":"10.1177\/2472555218755629_bib40","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1177\/1087057109347779","article-title":"Successful Identification of Glycine Transporter Inhibitors Using an Adaptation of a Functional Cell-Based Assay","volume":"14","author":"Kopec","year":"2009","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/2472555218755629_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1021\/acschembio.6b00913","article-title":"Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening","volume":"12","author":"Kutchukian","year":"2017","journal-title":"ACS Chem. Biol."},{"key":"10.1177\/2472555218755629_bib42","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/1087057113493006","article-title":"OCTN Cation Transporters in Health and Disease: Role as Drug Targets and Assay Development","volume":"18","author":"Pochini","year":"2013","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/2472555218755629_bib43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0003-2697(03)00431-7","article-title":"Development of a Scintillation Proximity Assay for Analysis of Na+\/Cl\u2013-Dependent Neurotransmitter Transporter Activity","volume":"321","author":"Williams","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1177\/2472555218755629_bib44","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1073\/pnas.0609573104","article-title":"Monitoring the Function of Membrane Transport Proteins in Detergent-Solubilized Form","volume":"104","author":"Quick","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev.bb.08.060179.000403","article-title":"Dye Indicators of Membrane Potential","volume":"8","author":"Waggoner","year":"1979","journal-title":"Annu. Rev. Biophys. Bioeng."},{"key":"10.1177\/2472555218755629_bib46","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/bph.13711","article-title":"Identification of Novel Inhibitors of the Amino Acid Transporter B(0) AT1 (SLC6A19), a Potential Target to Induce Protein Restriction and to Treat Type 2 Diabetes","volume":"174","author":"Cheng","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1177\/2472555218755629_bib47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/138620706775213886","article-title":"Development of a Novel High-Throughput Assay for the Investigation of GlyT-1b Neurotransmitter Transporter Function","volume":"9","author":"Allan","year":"2006","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1177\/2472555218755629_bib48","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/1087057104274090","article-title":"Validation of a Fluorescent Imaging Plate Reader Membrane Potential Assay for High-Throughput Screening of Glycine Transporter Modulators","volume":"10","author":"Benjamin","year":"2005","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/2472555218755629_bib49","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1021\/jm060822s","article-title":"Stereoselective Chemoenzymatic Synthesis of the Four Stereoisomers of l-2-(2-Carboxycyclobutyl)Glycine and Pharmacological Characterization at Human Excitatory Amino Acid Transporter Subtypes 1, 2, and 3","volume":"49","author":"Faure","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1177\/2472555218755629_bib50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00249-016-1173-7","article-title":"Comparison of Fluorescence Probes for Intracellular Sodium Imaging in Prostate Cancer Cell Lines","volume":"45","author":"Iamshanova","year":"2016","journal-title":"Eur. Biophys. J."},{"key":"10.1177\/2472555218755629_bib51","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1111\/j.1476-5381.1995.tb15958.x","article-title":"Stereoselective Uptake of Beta-Lactam Antibiotics by the Intestinal Peptide Transporter","volume":"116","author":"Wenzel","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1177\/2472555218755629_bib52","doi-asserted-by":"crossref","first-page":"e38591","DOI":"10.1371\/journal.pone.0038591","article-title":"Visualization of Glutamine Transporter Activities in Living Cells Using Genetically Encoded Glutamine Sensors","volume":"7","author":"Gruenwald","year":"2012","journal-title":"PLoS One"},{"key":"10.1177\/2472555218755629_bib53","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00424-015-1754-9","article-title":"Real-Time Functional Characterization of Cationic Amino Acid Transporters Using a New FRET Sensor","volume":"468","author":"Vanoaica","year":"2016","journal-title":"Pflugers Arch."},{"key":"10.1177\/2472555218755629_bib54","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/pro.2721","article-title":"Construction of a Robust and Sensitive Arginine Biosensor through Ancestral Protein Reconstruction","volume":"24","author":"Whitfield","year":"2015","journal-title":"Protein Sci."},{"key":"10.1177\/2472555218755629_bib55","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ymben.2012.02.002","article-title":"The Development and Application of a Single-Cell Biosensor for the Detection of L-Methionine and Branched-Chain Amino Acids","volume":"14","author":"Mustafi","year":"2012","journal-title":"Metab. Eng."},{"key":"10.1177\/2472555218755629_bib56","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/rcm.4984","article-title":"Ultrafast Mass Spectrometry Based Bioanalytical Method for Digoxin Supporting an In Vitro P-Glycoprotein (P-gp) Inhibition Screen","volume":"25","author":"Wagner","year":"2011","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1177\/2472555218755629_bib57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/2211068215619124","article-title":"Novel Acoustic Loading of a Mass Spectrometer: Toward Next-Generation High-Throughput MS Screening","volume":"21","author":"Sinclair","year":"2016","journal-title":"J. Lab. Autom."},{"key":"10.1177\/2472555218755629_bib58","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1039\/C6MD00005C","article-title":"SLC Transporters: Structure, Function, and Drug Discovery","volume":"7","author":"Colas","year":"2016","journal-title":"Medchemcomm"},{"key":"10.1177\/2472555218755629_bib59","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nature17629","article-title":"X-Ray Structures and Mechanism of the Human Serotonin Transporter","volume":"532","author":"Coleman","year":"2016","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib60","doi-asserted-by":"crossref","first-page":"e1004477","DOI":"10.1371\/journal.pcbi.1004477","article-title":"Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening","volume":"11","author":"Colas","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1177\/2472555218755629_bib61","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1073\/pnas.1218165110","article-title":"Structure-Based Ligand Discovery for the Large-Neutral Amino Acid Transporter 1, LAT-1","volume":"110","author":"Geier","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib62","doi-asserted-by":"crossref","first-page":"e0138957","DOI":"10.1371\/journal.pone.0138957","article-title":"Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening","volume":"10","author":"Ruggeri","year":"2015","journal-title":"PLoS One"},{"key":"10.1177\/2472555218755629_bib63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd2438","article-title":"Carrier-Mediated Cellular Uptake of Pharmaceutical Drugs: An Exception or the Rule?","volume":"7","author":"Dobson","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1177\/2472555218755629_bib64","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2174\/1568026611313070007","article-title":"Molecular Modeling and Ligand Docking for Solute Carrier (SLC) Transporters","volume":"13","author":"Schlessinger","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1177\/2472555218755629_bib65","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-biophys-083012-130312","article-title":"Electrophysiological Characterization of Membrane Transport Proteins","volume":"42","author":"Grewer","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"10.1177\/2472555218755629_bib66","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1161\/01.CIR.94.10.2572","article-title":"Molecular Physiology and Pharmacology of HERG. Single-Channel Currents and Block by Dofetilide","volume":"94","author":"Kiehn","year":"1996","journal-title":"Circulation"},{"key":"10.1177\/2472555218755629_bib67","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BJ20091515","article-title":"AR-C155858 Is a Potent Inhibitor of Monocarboxylate Transporters MCT1 and MCT2 That Binds to an Intracellular Site Involving Transmembrane Helices 7\u201310","volume":"425","author":"Ovens","year":"2010","journal-title":"Biochem. J."},{"key":"10.1177\/2472555218755629_bib68","first-page":"11083","article-title":"Unidirectional Reconstitution and Characterization of Purified Na+\/Proline Transporter of","volume":"37","author":"Jung","year":"1998","journal-title":"Escherichia coli. Biochemistry"},{"key":"10.1177\/2472555218755629_bib69","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature12265","article-title":"Transport Dynamics in a Glutamate Transporter Homologue","volume":"502","author":"Akyuz","year":"2013","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib70","first-page":"3183","article-title":"Genome-Wide Scan of Obesity in Finnish Sibpairs Reveals Linkage to Chromosome Xq24","volume":"85","author":"Ohman","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1177\/2472555218755629_bib71","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1172\/JCI200317491","article-title":"The SLC6A14 Gene Shows Evidence of Association with Obesity","volume":"112","author":"Suviolahti","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1177\/2472555218755629_bib72","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.2337\/diabetes.53.9.2483","article-title":"Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians","volume":"53","author":"Durand","year":"2004","journal-title":"Diabetes"},{"key":"10.1177\/2472555218755629_bib73","doi-asserted-by":"crossref","first-page":"23740","DOI":"10.1074\/jbc.274.34.23740","article-title":"Cloning and Functional Expression of a Human Na(+) and Cl(\u2013)-Dependent Neutral and Cationic Amino Acid Transporter B(0+)","volume":"274","author":"Sloan","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/humupd\/dmi044","article-title":"System B0,+ Amino Acid Transport Regulates the Penetration Stage of Blastocyst Implantation with Possible Long-Term Developmental Consequences through Adulthood","volume":"12","author":"Van Winkle","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1177\/2472555218755629_bib75","doi-asserted-by":"crossref","first-page":"24467","DOI":"10.1074\/jbc.M400904200","article-title":"Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder","volume":"279","author":"Broer","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib76","first-page":"48","article-title":"Branched-Chain Amino Acids as Biomarkers in Diabetes","volume":"19","author":"Giesbertz","year":"2016","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1177\/2472555218755629_bib77","doi-asserted-by":"crossref","first-page":"2794591","DOI":"10.1155\/2016\/2794591","article-title":"The Relationship between Branched-Chain Amino Acid Related Metabolomic Signature and Insulin Resistance: A Systematic Review","volume":"2016","author":"Zhao","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1177\/2472555218755629_bib78","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-Chain Amino Acids in Metabolic Signalling and Insulin Resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1177\/2472555218755629_bib79","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.cmet.2012.01.024","article-title":"Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance","volume":"15","author":"Newgard","year":"2012","journal-title":"Cell Metab."},{"key":"10.1177\/2472555218755629_bib80","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.cub.2004.08.026","article-title":"Inappropriate Activation of the TSC\/Rheb\/mTOR\/S6K Cassette Induces IRS1\/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies","volume":"14","author":"Shah","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1177\/2472555218755629_bib81","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2337\/diabetes.51.3.599","article-title":"Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans","volume":"51","author":"Krebs","year":"2002","journal-title":"Diabetes"},{"key":"10.1177\/2472555218755629_bib82","doi-asserted-by":"crossref","first-page":"C518","DOI":"10.1152\/ajpcell.00062.2016","article-title":"Ketoisocaproic Acid, a Metabolite of Leucine, Suppresses Insulin-Stimulated Glucose Transport in Skeletal Muscle Cells in a BCAT2-Dependent Manner","volume":"311","author":"Moghei","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1177\/2472555218755629_bib83","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.cmet.2014.02.009","article-title":"The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice","volume":"19","author":"Solon-Biet","year":"2014","journal-title":"Cell Metab."},{"key":"10.1177\/2472555218755629_bib84","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/nyas.13014","article-title":"Methionine Restriction Beyond Life-Span Extension","volume":"1363","author":"Ables","year":"2016","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1177\/2472555218755629_bib85","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2337\/dc16-0145","article-title":"Mechanisms of Diabetes Improvement Following Bariatric\/Metabolic Surgery","volume":"39","author":"Batterham","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1177\/2472555218755629_bib86","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/ng1406","article-title":"Hartnup Disorder Is Caused by Mutations in the Gene Encoding the Neutral Amino Acid Transporter SLC6A19","volume":"36","author":"Seow","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1177\/2472555218755629_bib87","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/ng1405","article-title":"Mutations in SLC6A19, Encoding B0AT1, Cause Hartnup Disorder","volume":"36","author":"Kleta","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1177\/2472555218755629_bib88","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bcp.2014.03.014","article-title":"Nimesulide Binding Site in the B0AT1 (SLC6A19) Amino Acid Transporter. Mechanism of Inhibition Revealed by Proteoliposome Transport Assay and Molecular Modelling","volume":"89","author":"Pochini","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1177\/2472555218755629_bib89","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mam.2012.10.007","article-title":"The SLC3 and SLC7 Families of Amino Acid Transporters","volume":"34","author":"Fotiadis","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1177\/2472555218755629_bib90","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy","volume":"136","author":"Nicklin","year":"2009","journal-title":"Cell"},{"key":"10.1177\/2472555218755629_bib91","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1254\/jphs.12124FP","article-title":"Establishment of Stable Cell Lines with High Expression of Heterodimers of Human 4F2hc and Human Amino Acid Transporter LAT1 or LAT2 and Delineation of Their Differential Interaction with Alpha-Alkyl Moieties","volume":"119","author":"Khunweeraphong","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"10.1177\/2472555218755629_bib92","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1530\/JME-15-0212","article-title":"System-L Amino Acid Transporters Play a Key Role in Pancreatic Beta-Cell Signalling and Function","volume":"56","author":"Cheng","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1177\/2472555218755629_bib93","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/bj1460457","article-title":"The Effects L-Leucine on the Synthesis of Urea, Glutamate and Glutamine by Isolated Rat Liver Cells","volume":"146","author":"Mourao","year":"1975","journal-title":"Biochem. J."},{"key":"10.1177\/2472555218755629_bib94","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.2337\/db06-0868","article-title":"Nutrient Control of Insulin Secretion in Isolated Normal Human Islets","volume":"55","author":"Henquin","year":"2006","journal-title":"Diabetes"},{"key":"10.1177\/2472555218755629_bib95","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2337\/diabetes.48.8.1535","article-title":"Glucose Regulation of Glutaminolysis and Its Role in Insulin Secretion","volume":"48","author":"Gao","year":"1999","journal-title":"Diabetes"},{"key":"10.1177\/2472555218755629_bib96","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bbrc.2009.02.062","article-title":"Complementary Expression of SN1 and SAT2 in the Islets of Langerhans Suggests Concerted Action of Glutamine Transport in the Regulation of Insulin Secretion","volume":"381","author":"Gammelsaeter","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1177\/2472555218755629_bib97","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1074\/jbc.M113.529065","article-title":"Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice","volume":"289","author":"Zhou","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib98","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrendo.2015.51","article-title":"Islet Alpha Cells and Glucagon\u2014Critical Regulators of Energy Homeostasis","volume":"11","author":"Campbell","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1177\/2472555218755629_bib99","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2337\/db11-1605","article-title":"Liver-Specific Disruption of the Murine Glucagon Receptor Produces Alpha-Cell Hyperplasia: Evidence for a Circulating Alpha-Cell Growth Factor","volume":"62","author":"Longuet","year":"2013","journal-title":"Diabetes"},{"key":"10.1177\/2472555218755629_bib100","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1124\/jpet.108.136267","article-title":"Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice","volume":"326","author":"Morita","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1177\/2472555218755629_bib101","first-page":"468","article-title":"Glycine Transport Inhibitors for the Treatment of Schizophrenia: Symptom and Disease Modification","volume":"12","author":"Javitt","year":"2009","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1177\/2472555218755629_bib102","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/j.1460-9568.2007.05446.x","article-title":"Evidence from Gene Knockout Studies Implicates Asc-1 as the Primary Transporter Mediating D-Serine Reuptake in the Mouse CNS","volume":"25","author":"Rutter","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1177\/2472555218755629_bib103","doi-asserted-by":"crossref","first-page":"e0156551","DOI":"10.1371\/journal.pone.0156551","article-title":"D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1\/SLC1A4 and ASCT2\/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures","volume":"11","author":"Foster","year":"2016","journal-title":"PLoS One"},{"key":"10.1177\/2472555218755629_bib104","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/jnr.23772","article-title":"A Novel Na(+)-Independent Alanine-Serine-Cysteine Transporter 1 Inhibitor Inhibits Both Influx and Efflux of D-Serine","volume":"94","author":"Sakimura","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"10.1177\/2472555218755629_bib105","first-page":"1573","article-title":"Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of D-Serine in the Forebrain","volume":"27","author":"Sason","year":"2017","journal-title":"Cereb. Cortex"},{"key":"10.1177\/2472555218755629_bib106","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biopsych.2016.11.014","article-title":"Bitopertin in Negative Symptoms of Schizophrenia\u2014Results from the Phase III FlashLyte and DayLyte Studies","volume":"82","author":"Bugarski-Kirola","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1177\/2472555218755629_bib107","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0896-6273(03)00672-X","article-title":"Inactivation of the Glycine Transporter 1 Gene Discloses Vital Role of Glial Glycine Uptake in Glycinergic Inhibition","volume":"40","author":"Gomeza","year":"2003","journal-title":"Neuron"},{"key":"10.1177\/2472555218755629_bib108","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nature03180","article-title":"Beta-Lactam Antibiotics Offer Neuroprotection by Increasing Glutamate Transporter Expression","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib109","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/1087057110370998","article-title":"Identification of Translational Activators of Glial Glutamate Transporter EAAT2 through Cell-Based High-Throughput Screening: An Approach to Prevent Excitotoxicity","volume":"15","author":"Colton","year":"2010","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/2472555218755629_bib110","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S1474-4422(14)70222-4","article-title":"Safety and Efficacy of Ceftriaxone for Amyotrophic Lateral Sclerosis: A Multi-Stage, Randomised, Double-Blind, Placebo-Controlled Trial","volume":"13","author":"Cudkowicz","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1177\/2472555218755629_bib111","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1172\/JCI66163","article-title":"Small-Molecule Activator of Glutamate Transporter EAAT2 Translation Provides Neuroprotection","volume":"124","author":"Kong","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1177\/2472555218755629_bib112","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00109-011-0730-x","article-title":"Therapeutic Targeting of Cancer Cell Metabolism","volume":"89","author":"Dang","year":"2011","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1177\/2472555218755629_bib113","first-page":"490","article-title":"Historic Milestones in Curative Chemotherapy","volume":"6","author":"Zubrod","year":"1979","journal-title":"Semin. Oncol."},{"key":"10.1177\/2472555218755629_bib114","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine Starvation Induces Stress and p53-Dependent Metabolic Remodelling in Cancer Cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib115","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF01116556","article-title":"The Role of High Rates of Glycolysis and Glutamine Utilization in Rapidly Dividing Cells","volume":"5","author":"Newsholme","year":"1985","journal-title":"Biosci. Rep."},{"key":"10.1177\/2472555218755629_bib116","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond Aerobic Glycolysis: Transformed Cells Can Engage in Glutamine Metabolism That Exceeds the Requirement for Protein and Nucleotide Synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib117","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1101\/gad.1985910","article-title":"The Hexosamine Biosynthetic Pathway Couples Growth Factor-Induced Glutamine Uptake to Glucose Metabolism","volume":"24","author":"Wellen","year":"2010","journal-title":"Genes Dev."},{"key":"10.1177\/2472555218755629_bib118","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccr.2013.08.020","article-title":"Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target","volume":"24","author":"Timmerman","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1177\/2472555218755629_bib119","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine Addiction: A New Therapeutic Target in Cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1177\/2472555218755629_bib120","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.bbamcr.2015.12.017","article-title":"Glutamine Transporters in Mammalian Cells and Their Functions in Physiology and Cancer","volume":"1863","author":"Bhutia","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/2472555218755629_bib121","doi-asserted-by":"crossref","first-page":"13194","DOI":"10.1074\/jbc.M115.700534","article-title":"Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells","volume":"291","author":"Broer","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib122","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.semcancer.2005.04.005","article-title":"Amino Acid Transporters ASCT2 and LAT1 in Cancer: Partners in Crime?","volume":"15","author":"Fuchs","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1177\/2472555218755629_bib123","doi-asserted-by":"crossref","first-page":"C55","DOI":"10.1152\/ajpcell.00330.2006","article-title":"ASCT2 Silencing Regulates Mammalian Target-of-Rapamycin Growth and Survival Signaling in Human Hepatoma Cells","volume":"293","author":"Fuchs","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1177\/2472555218755629_bib124","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/path.4518","article-title":"Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development","volume":"236","author":"Wang","year":"2015","journal-title":"J. Pathol."},{"key":"10.1177\/2472555218755629_bib125","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/ijc.28749","article-title":"Targeting Glutamine Transport to Suppress Melanoma Cell Growth","volume":"135","author":"Wang","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1177\/2472555218755629_bib126","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1038\/onc.2015.381","article-title":"ASCT2\/SLC1A5 Controls Glutamine Uptake and Tumour Growth in Triple-Negative Basal-Like Breast Cancer","volume":"35","author":"van Geldermalsen","year":"2016","journal-title":"Oncogene"},{"key":"10.1177\/2472555218755629_bib127","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1113\/jphysiol.2004.062521","article-title":"New Inhibitors for the Neutral Amino Acid Transporter ASCT2 Reveal Its Na+-Dependent Anion Leak","volume":"557","author":"Grewer","year":"2004","journal-title":"J. Physiol."},{"key":"10.1177\/2472555218755629_bib128","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bmc.2004.11.028","article-title":"Ngamma-Aryl Glutamine Analogues as Probes of the ASCT2 Neutral Amino Acid Transporter Binding Site","volume":"13","author":"Esslinger","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"10.1177\/2472555218755629_bib129","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.bmcl.2015.12.031","article-title":"2-Amino-4-Bis(Aryloxybenzyl)Aminobutanoic Acids: A Novel Scaffold for Inhibition of ASCT2-Mediated Glutamine Transport","volume":"26","author":"Schulte","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1177\/2472555218755629_bib130","first-page":"3399","article-title":"Anti-Tumor Efficacy Evaluation of a Novel Monoclonal Antibody Targeting Neutral Amino Acid Transporter ASCT2 Using Patient-Derived Xenograft Mouse Models of Gastric Cancer","volume":"9","author":"Kasai","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1177\/2472555218755629_bib131","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3389\/fimmu.2017.00549","article-title":"ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production","volume":"8","author":"Masle-Farquhar","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1177\/2472555218755629_bib132","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4251\/wjgo.v9.i1.21","article-title":"Novel Therapeutic Approaches Targeting L-Type Amino Acid Transporters for Cancer Treatment","volume":"9","author":"Hayashi","year":"2017","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1177\/2472555218755629_bib133","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1111\/j.1349-7006.2008.00969.x","article-title":"L-Type Amino Acid Transporter 1 and CD98 Expression in Primary and Metastatic Sites of Human Neoplasms","volume":"99","author":"Kaira","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1177\/2472555218755629_bib134","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/sj.bjc.6604235","article-title":"Prognostic Significance of L-Type Amino Acid Transporter 1 Expression in Resectable Stage I-III Nonsmall Cell Lung Cancer","volume":"98","author":"Kaira","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1177\/2472555218755629_bib135","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1158\/0008-5472.CAN-15-3376","article-title":"Genetic Disruption of the Multifunctional CD98\/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth","volume":"76","author":"Cormerais","year":"2016","journal-title":"Cancer Res."},{"key":"10.1177\/2472555218755629_bib136","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1158\/0008-5472.CAN-11-1821","article-title":"Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression","volume":"71","author":"Wang","year":"2011","journal-title":"Cancer Res."},{"key":"10.1177\/2472555218755629_bib137","doi-asserted-by":"crossref","first-page":"C1077","DOI":"10.1152\/ajpcell.2001.281.4.C1077","article-title":"Function and Structure of Heterodimeric Amino Acid Transporters","volume":"281","author":"Wagner","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1177\/2472555218755629_bib138","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/1389200013338324","article-title":"Heterodimeric Amino Acid Transporters: Molecular Biology and Pathological and Pharmacological Relevance","volume":"2","author":"Kanai","year":"2001","journal-title":"Curr. Drug Metab."},{"key":"10.1177\/2472555218755629_bib139","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.biocel.2015.08.004","article-title":"LAT1 Is the Transport Competent Unit of the LAT1\/CD98 Heterodimeric Amino Acid Transporter","volume":"67","author":"Napolitano","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1177\/2472555218755629_bib140","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1248\/bpb.31.1096","article-title":"BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells","volume":"31","author":"Kim","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1177\/2472555218755629_bib141","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bcp.2017.07.006","article-title":"Potent Inhibitors of Human LAT1 (SLC7A5) Transporter Based on Dithiazole and Dithiazine Compounds for Development of Anticancer Drugs","volume":"143","author":"Napolitano","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1177\/2472555218755629_bib142","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/ijc.30371","article-title":"LAT1 Is a Putative Therapeutic Target in Endometrioid Endometrial Carcinoma","volume":"139","author":"Marshall","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1177\/2472555218755629_bib143","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jphs.2017.01.006","article-title":"Structure-Activity Relationship of a Novel Series of Inhibitors for Cancer Type Transporter L-Type Amino Acid Transporter 1 (LAT1)","volume":"133","author":"Kongpracha","year":"2017","journal-title":"J. Pharmacol. Sci."},{"key":"10.1177\/2472555218755629_bib144","doi-asserted-by":"crossref","first-page":"12079","DOI":"10.1073\/pnas.96.21.12079","article-title":"Selective Expression of the Large Neutral Amino Acid Transporter at the Blood-Brain Barrier","volume":"96","author":"Boado","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib145","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ni.2556","article-title":"Control of Amino-Acid Transport by Antigen Receptors Coordinates the Metabolic Reprogramming Essential for T Cell Differentiation","volume":"14","author":"Sinclair","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1177\/2472555218755629_bib146","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0006-291X(03)01473-6","article-title":"The Targeted Disruption of the CD98 Gene Results in Embryonic Lethality","volume":"308","author":"Tsumura","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1177\/2472555218755629_bib147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01870891","article-title":"Role of Membrane Transport in Metabolism and Function of Glutathione in Mammals","volume":"89","author":"Bannai","year":"1986","journal-title":"J. Membr. Biol."},{"key":"10.1177\/2472555218755629_bib148","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao6604","article-title":"Oncogenic PI3K Promotes Methionine Dependency in Breast Cancer Cells through the Cystine-Glutamate Antiporter xCT","volume":"10","author":"Lien","year":"2017","journal-title":"Sci. Signal"},{"key":"10.1177\/2472555218755629_bib149","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-Mediated Activity during Tumour Suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib150","doi-asserted-by":"crossref","first-page":"1485283","DOI":"10.1155\/2017\/1485283","article-title":"Reactive Oxygen Species-Mediated Mechanisms of Action of Targeted Cancer Therapy","volume":"2017","author":"Teppo","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1177\/2472555218755629_bib151","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbadis.2005.04.002","article-title":"Upregulation of the Amino Acid Transporter ATB0,+ (SLC6A14) in Colorectal Cancer and Metastasis in Humans","volume":"1741","author":"Gupta","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/2472555218755629_bib152","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygyno.2005.08.016","article-title":"Up-Regulation of the Amino Acid Transporter ATB(0,+) (SLC6A14) in Carcinoma of the Cervix","volume":"100","author":"Gupta","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"10.1177\/2472555218755629_bib153","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/BJ20080622","article-title":"Interaction of Tryptophan Derivatives with SLC6A14 (ATB0,+) Reveals the Potential of the Transporter as a Drug Target for Cancer Chemotherapy","volume":"414","author":"Karunakaran","year":"2008","journal-title":"Biochem. J."},{"key":"10.1177\/2472555218755629_bib154","doi-asserted-by":"crossref","first-page":"31830","DOI":"10.1074\/jbc.M111.229518","article-title":"SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-Positive Breast Cancer","volume":"286","author":"Karunakaran","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib155","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BJ20150437","article-title":"Deletion of the Amino Acid Transporter Slc6a14 Suppresses Tumour Growth in Spontaneous Mouse Models of Breast Cancer","volume":"469","author":"Babu","year":"2015","journal-title":"Biochem. J."},{"key":"10.1177\/2472555218755629_bib156","doi-asserted-by":"crossref","first-page":"43838","DOI":"10.1074\/jbc.M305221200","article-title":"Identification of a Novel System L Amino Acid Transporter Structurally Distinct from Heterodimeric Amino Acid Transporters","volume":"278","author":"Babu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib157","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/geno.2001.6678","article-title":"The Human T-Type Amino Acid Transporter-1: Characterization, Gene Organization, and Chromosomal Location","volume":"79","author":"Kim","year":"2002","journal-title":"Genomics"},{"key":"10.1177\/2472555218755629_bib158","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0014-5793(01)02126-3","article-title":"The Adaptive Regulation of Amino Acid Transport System A Is Associated to Changes in ATA2 Expression","volume":"490","author":"Gazzola","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1177\/2472555218755629_bib159","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1074\/jbc.M310483200","article-title":"Transcriptional Control of the Human Sodium-Coupled Neutral Amino Acid Transporter System A Gene by Amino Acid Availability Is Mediated by an Intronic Element","volume":"279","author":"Palii","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib160","doi-asserted-by":"crossref","first-page":"17929","DOI":"10.1074\/jbc.M600341200","article-title":"Amino Acid Starvation Induces the SNAT2 Neutral Amino Acid Transporter by a Mechanism That Involves Eukaryotic Initiation Factor 2alpha Phosphorylation and Cap-Independent Translation","volume":"281","author":"Gaccioli","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib161","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ccell.2015.02.006","article-title":"Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies","volume":"27","author":"Jeon","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1177\/2472555218755629_bib162","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1074\/jbc.M114.625137","article-title":"Proteasomal Modulation of Cellular SNAT2 (SLC38A2) Abundance and Function by Unsaturated Fatty Acid Availability","volume":"290","author":"Nardi","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib163","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11596-017-1690-3","article-title":"SLC38A1 Promotes Proliferation and Migration of Human Colorectal Cancer Cells","volume":"37","author":"Zhou","year":"2017","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci."},{"key":"10.1177\/2472555218755629_bib164","first-page":"514","article-title":"shRNA-Mediated Slc38a1 Silencing Inhibits Migration, but Not Invasiveness of Human Pancreatic Cancer Cells","volume":"25","author":"Xie","year":"2013","journal-title":"Chin. J. Cancer Res."},{"key":"10.1177\/2472555218755629_bib165","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0026-895X(24)26443-9","article-title":"Substrate Supply for Nitric-Oxide Synthase in Macrophages and Endothelial Cells: Role of Cationic Amino Acid Transporters","volume":"57","author":"Closs","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1177\/2472555218755629_bib166","doi-asserted-by":"crossref","first-page":"e33546","DOI":"10.1371\/journal.pone.0033546","article-title":"L-Arginine Supplementation Improves Responses to Injury and Inflammation in Dextran Sulfate Sodium Colitis","volume":"7","author":"Coburn","year":"2012","journal-title":"PLoS One"},{"key":"10.1177\/2472555218755629_bib167","doi-asserted-by":"crossref","first-page":"G225","DOI":"10.1152\/ajpgi.00091.2013","article-title":"Deletion of Cationic Amino Acid Transporter 2 Exacerbates Dextran Sulfate Sodium Colitis and Leads to an IL-17-Predominant T Cell Response","volume":"305","author":"Singh","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1177\/2472555218755629_bib168","doi-asserted-by":"crossref","first-page":"14895","DOI":"10.1073\/pnas.0605478103","article-title":"Cationic Amino Acid Transporter 2 Regulates Inflammatory Homeostasis in the Lung","volume":"103","author":"Rothenberg","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555218755629_bib169","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.immuni.2014.04.007","article-title":"Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation","volume":"40","author":"Nakaya","year":"2014","journal-title":"Immunity"},{"key":"10.1177\/2472555218755629_bib170","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1113\/jphysiol.2012.239574","article-title":"T-Type Amino Acid Transporter TAT1 (Slc16a10) Is Essential for Extracellular Aromatic Amino Acid Homeostasis Control","volume":"590","author":"Mariotta","year":"2012","journal-title":"J. Physiol."},{"key":"10.1177\/2472555218755629_bib171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20120627","article-title":"Advances in Our Understanding of the Pathophysiology of Type 1 Diabetes: Lessons from the NOD Mouse","volume":"126","author":"Jayasimhan","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1177\/2472555218755629_bib172","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1534\/g3.115.021709","article-title":"Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes","volume":"5","author":"Elso","year":"2015","journal-title":"G3"},{"key":"10.1177\/2472555218755629_bib173","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0304-4157(88)90024-X","article-title":"Amino Acid Transport in Developing Animal Oocytes and Early Conceptuses","volume":"947","author":"Van Winkle","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/2472555218755629_bib174","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0005-2736(90)90387-4","article-title":"Changes in the Activities of Amino Acid Transport Systems b0,+ and L during Development of Preimplantation Mouse Conceptuses","volume":"1021","author":"Van Winkle","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1177\/2472555218755629_bib175","doi-asserted-by":"crossref","first-page":"C1270","DOI":"10.1152\/ajpcell.00235.2010","article-title":"The Amino Acid Transporter SNAT2 Mediates L-Proline-Induced Differentiation of ES Cells","volume":"300","author":"Tan","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1177\/2472555218755629_bib176","doi-asserted-by":"crossref","first-page":"33094","DOI":"10.1074\/jbc.M112.365478","article-title":"Betaine Homocysteine Methyltransferase Is Active in the Mouse Blastocyst and Promotes Inner Cell Mass Development","volume":"287","author":"Lee","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1177\/2472555218755629_bib177","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4161\/epi.24042","article-title":"Bridging Epigenetics and Metabolism: Role of Non-Essential Amino Acids","volume":"8","author":"Phang","year":"2013","journal-title":"Epigenetics"},{"key":"10.1177\/2472555218755629_bib178","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.cell.2015.07.022","article-title":"A Call for Systematic Research on Solute Carriers","volume":"162","author":"Cesar-Razquin","year":"2015","journal-title":"Cell"},{"key":"10.1177\/2472555218755629_bib179","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature12828","article-title":"Sequence Variants in SLC16A11 Are a Common Risk Factor for Type 2 Diabetes in Mexico","volume":"506","author":"Consortium","year":"2014","journal-title":"Nature"},{"key":"10.1177\/2472555218755629_bib180","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cell.2017.06.011","article-title":"Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms","volume":"170","author":"Rusu","year":"2017","journal-title":"Cell"},{"key":"10.1177\/2472555218755629_bib181","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1124\/mol.53.2.195","article-title":"DL-Threo-Beta-Benzyloxyaspartate, a Potent Blocker of Excitatory Amino Acid Transporters","volume":"53","author":"Shimamoto","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1177\/2472555218755629_bib182","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature08616","article-title":"Transport Mechanism of a Bacterial Homologue of Glutamate Transporters","volume":"462","author":"Reyes","year":"2009","journal-title":"Nature"}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2472555218755629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2472555218755629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222068599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222068599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2472555218755629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:48:43Z","timestamp":1762861723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222068599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":182,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S2472555222068599"],"URL":"https:\/\/doi.org\/10.1177\/2472555218755629","relation":{},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amino Acid Transporters as Disease Modifiers and Drug Targets","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/2472555218755629","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}