{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:03:28Z","timestamp":1792181008035,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":799,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["5T32NR007081-15, 5T32NR007091-22, Ruth L. Kirschstein National Research Service Award"],"award-info":[{"award-number":["5T32NR007081-15, 5T32NR007091-22, Ruth L. Kirschstein National Research Service Award"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"american cancer society","doi-asserted-by":"publisher","award":["Doctoral Degree Scholarship in Cancer Nursing"],"award-info":[{"award-number":["Doctoral Degree Scholarship in Cancer Nursing"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"national cancer institute","doi-asserted-by":"publisher","award":["R01 CA232887 (with NIH)"],"award-info":[{"award-number":["R01 CA232887 (with NIH)"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1177\/2472555219860771","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T16:04:07Z","timestamp":1564502647000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-3973","authenticated-orcid":false,"given":"Tara","family":"Walhart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Isaacson-Wechsler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kean-Hooi","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Arkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharof","family":"Tugizov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Palefsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1177\/2472555219860771_bib1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1128\/JVI.78.2.751-757.2004","article-title":"Efficient Intracellular Assembly of Papillomaviral Vectors","volume":"78","author":"Buck","year":"2004","journal-title":"J. Virol."},{"key":"10.1177\/2472555219860771_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.soc.2016.07.010","article-title":"Human Immunodeficiency Virus\/AIDS, Human Papillomavirus, and Anal Cancer","volume":"26","author":"Wang","year":"2017","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"10.1177\/2472555219860771_bib3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/bjs.5376","article-title":"Molecular Biology of Squamous Cell Carcinoma of the Anus","volume":"93","author":"Gervaz","year":"2006","journal-title":"Br. J. Surg."},{"key":"10.1177\/2472555219860771_bib4","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.1016\/S1470-2045(15)00292-2","article-title":"Molecular Biology of Anal Squamous Cell Carcinoma: Implications for Future Research and Clinical Intervention","volume":"16","author":"Bernardi","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1177\/2472555219860771_bib5","unstructured":"National Institutes of Health, National Cancer Institute. HPV and Cancer. https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/infectious-agents\/hpv-and-cancer?redirect=true (accessed June 30, 2019)."},{"key":"10.1177\/2472555219860771_bib6","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/LGT.0000000000000437","article-title":"Prevalence of Anal Squamous Intraepithelial Lesions in HIV-1\u2013Infected Young Men Who Have Sex with Men and Transwomen","volume":"22","author":"Thompson","year":"2018","journal-title":"J. Low. Genit. Tract Dis."},{"key":"10.1177\/2472555219860771_bib7","doi-asserted-by":"crossref","first-page":"S370","DOI":"10.1097\/QAI.0000000000001413","article-title":"Increasing Human Papillomavirus Vaccine Coverage among Men Who Have Sex with Men\u2014National HIV Behavioral Surveillance, United States, 2014","volume":"75","author":"Oliver","year":"2017","journal-title":"JAIDS J. Acquir. Immune Defic. Syndr."},{"key":"10.1177\/2472555219860771_bib8","first-page":"300","article-title":"Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated HPV Vaccination Recommendations of the Advisory Committee on Immunization Practices","volume":"64","author":"Petrosky","year":"2015","journal-title":"MMWR. Morb. Mortal. Wkly. Rep."},{"key":"10.1177\/2472555219860771_bib9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.antiviral.2011.12.007","article-title":"Novel Antivirals Inhibit Early Steps in HPV Infection","volume":"93","author":"Huang","year":"2012","journal-title":"Antiviral Res."},{"key":"10.1177\/2472555219860771_bib10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nrd3368","article-title":"Impact of High-Throughput Screening in Biomedical Research","volume":"10","author":"Macarron","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1177\/2472555219860771_bib11","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1371\/journal.ppat.0020069","article-title":"Carrageenan Is a Potent Inhibitor of Papillomavirus Infection","volume":"2","author":"Buck","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1177\/2472555219860771_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.virol.2009.12.026","article-title":"Development of Quantitative and High-Throughput Assays of Polyomavirus and Papillomavirus DNA Replication","volume":"399","author":"Fradet-Turcotte","year":"2010","journal-title":"Virology"},{"key":"10.1177\/2472555219860771_bib13","doi-asserted-by":"crossref","first-page":"e1006168","DOI":"10.1371\/journal.ppat.1006168","article-title":"Identification of Several High-Risk HPV Inhibitors and Drug Targets with a Novel High-Throughput Screening Assay","volume":"13","author":"Toots","year":"2017","journal-title":"PLOS Pathog."},{"key":"10.1177\/2472555219860771_bib14","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1158\/1541-7786.MCR-17-0060","article-title":"Comprehensive Genomic Profiling of Metastatic Squamous Cell Carcinoma of the Anal Canal","volume":"15","author":"Morris","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"10.1177\/2472555219860771_bib15","article-title":"Production of Papillomavirus-Based Gene Transfer Vectors","volume":"37","author":"Buck","year":"2007","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1177\/2472555219860771_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1087057112455219","article-title":"Theoretical and Experimental Relationships between Percent Inhibition and IC50 Data Observed in High-Throughput Screening","volume":"18","author":"Gubler","year":"2013","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/2472555219860771_bib17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrd1063","article-title":"Designing Screens: How to Make Your Hits a Hit","volume":"2","author":"Walters","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1177\/2472555219860771_bib18","unstructured":"GraphPad Software. Principals of Fitting a Curve. https:\/\/cdn.graphpad.com\/docs\/prism\/6\/Prism-6-Curve-Fitting-Guide.pdf (accessed June 30, 2019)."},{"key":"10.1177\/2472555219860771_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/2472555219860771_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4161\/cc.3.4.801","article-title":"Small-Molecule Antagonists of P53-MDM2 Binding: Research Tools and Potential Therapeutics","volume":"3","author":"Vassilev","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1177\/2472555219860771_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0009-2797(02)00241-7","article-title":"Apoptosis Enzyme-Linked Immunosorbent Assay Distinguishes Anticancer Drugs from Toxic Chemicals and Predicts Drug Synergism","volume":"145","author":"Frankfurt","year":"2003","journal-title":"Chem. Biol. Interact."},{"key":"10.1177\/2472555219860771_bib22","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1128\/JVI.75.3.1565-1570.2001","article-title":"Human Papillomavirus Infection Requires Cell Surface Heparan Sulfate","volume":"75","author":"Giroglou","year":"2001","journal-title":"J. Virol."},{"key":"10.1177\/2472555219860771_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.virol.2005.04.011","article-title":"Cross-Neutralization of Cutaneous and Mucosal Papillomavirus Types with Anti-Sera to the Amino Terminus of L2","volume":"337","author":"Pastrana","year":"2005","journal-title":"Virology"},{"key":"10.1177\/2472555219860771_bib24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ab.2004.06.023","article-title":"High-Throughput Methods for Measuring Heparanase Activity and Screening Potential Antimetastatic and Anti-Inflammatory Agents","volume":"333","author":"Huang","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1177\/2472555219860771_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-0035-1570394","article-title":"Screening, Surveillance, and Treatment of Anal Intraepithelial Neoplasia","volume":"29","author":"Long","year":"2016","journal-title":"Clin. Colon Rectal Surg."}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2472555219860771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2472555219860771","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222065170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222065170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2472555219860771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:50:42Z","timestamp":1762861842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222065170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S2472555222065170"],"URL":"https:\/\/doi.org\/10.1177\/2472555219860771","relation":{},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/2472555219860771","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}