{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:37:15Z","timestamp":1762868235349,"version":"build-2065373602"},"reference-count":99,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":476,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1177\/2472555220950236","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T12:50:20Z","timestamp":1597668620000},"page":"1123-1140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates"],"prefix":"10.1016","volume":"25","author":[{"given":"Jilan","family":"Nazeam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esraa Z.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Raafat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Houssein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Elkafoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dina","family":"Hamdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Jamil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1177\/2472555220950236_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12098-020-03263-6","article-title":"A Review of Coronavirus Disease-2019 (COVID-19)","volume":"87","author":"Singhal","year":"2020","journal-title":"Indian J. Pediatr."},{"key":"10.1177\/2472555220950236_bib2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2020.03.005","article-title":"COVID-19 Infection: Origin, Transmission, and Characteristics of Human Coronaviruses","volume":"24","author":"Khan","year":"2020","journal-title":"J. Adv. Res."},{"key":"10.1177\/2472555220950236_bib3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jinf.2020.02.027","article-title":"Identification of the Hyper-Variable Genomic Hotspot for the Novel Coronavirus SARS-CoV-2","volume":"80","author":"Wen","year":"2020","journal-title":"J. Infect."},{"key":"10.1177\/2472555220950236_bib4","first-page":"1","article-title":"2019 Novel Coronavirus (Covid-19) Outbreak: A Review of the Current Literature","volume":"4","author":"Sahin","year":"2020","journal-title":"Eurasian J. Med. Oncol."},{"key":"10.1177\/2472555220950236_bib5","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1007\/s11606-020-05762-w","article-title":"Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19)","volume":"35","author":"Jiang","year":"2020","journal-title":"J. Gen. Intern. Med."},{"issue":"36","key":"10.1177\/2472555220950236_bib6","first-page":"1","article-title":"Time to Rethink the Systematic Review Catechism? Moving from \u2018What Works\u2019 to \u2018What Happens\u2019","volume":"4","author":"Petticrew","year":"2015","journal-title":"Syst. Rev."},{"key":"10.1177\/2472555220950236_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/v11010059","article-title":"From SARS to MERS, Thrusting Coronaviruses into the Spotlight","volume":"11","author":"Song","year":"2019","journal-title":"Viruses"},{"key":"10.1177\/2472555220950236_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrmicro2090","article-title":"The Spike Protein of SARS-CoV\u2014A Target for Vaccine and Therapeutic Development","volume":"7","author":"Du","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1177\/2472555220950236_bib9","first-page":"1","article-title":"Coronaviruses: An Overview of Their Replication and Pathogenesis in Coronaviruses","volume":"1282","author":"Fehr","year":"2015","journal-title":"Methods Protoc."},{"key":"10.1177\/2472555220950236_bib10","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.7150\/ijbs.45538","article-title":"Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective","volume":"16","author":"Yang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"10.1177\/2472555220950236_bib11","doi-asserted-by":"crossref","unstructured":"Shajahan A., Supekar N. T., Gleinich A. S.; et al. Deducing the N- and O-Glycosylation Profile of the Spike Protein of Novel Coronavirus SARS-CoV-2. Glycobiology 2020. DOI: 10.1093\/glycob\/cwaa042.","DOI":"10.1101\/2020.04.01.020966"},{"key":"10.1177\/2472555220950236_bib12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic Characterisation and Epidemiology of 2019 Novel Coronavirus: Implications for Virus Origins and Receptor Binding","volume":"395","author":"Lu","year":"2020","journal-title":"Lancet"},{"key":"10.1177\/2472555220950236_bib13","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging Coronaviruses: Genome Structure, Replication, and Pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1177\/2472555220950236_bib14","first-page":"418","article-title":"The Continuing 2019-nCoV Epidemic Threat of Novel Coronaviruses to Global Health\u2014The Latest 2019 Novel Coronavirus Outbreak in Wuhan, China","volume":"92","author":"Hui","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"10.1177\/2472555220950236_bib15","doi-asserted-by":"crossref","unstructured":"Wan Y., Shang J., Graham R.; et al. Receptor Recognition by the Novel Coronavirus from Wuhan: An Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J. Virol. 2020. DOI: 10.1128\/JVI.00127-20.","DOI":"10.1128\/JVI.00127-20"},{"key":"10.1177\/2472555220950236_bib16","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3390\/v4061011","article-title":"Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein","volume":"4","author":"Belouzard","year":"2012","journal-title":"Viruses"},{"key":"10.1177\/2472555220950236_bib17","first-page":"20669","article-title":"The Agent and Host Factors in Covid-19: Exploring Pathogenesis and Therapeutic Implications","volume":"27","author":"Vinod","year":"2020","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"10.1177\/2472555220950236_bib18","doi-asserted-by":"crossref","unstructured":"Shajahan A., Archer-hartmann S. A., Supekar N. T.; et al. Comprehensive Characterization of N- and O-Glycosylation of SARS-CoV-2 Human Receptor Angiotensin Converting Enzyme 2. bioRxiv 2020. DOI: 10.1101\/2020.05.01.071688.","DOI":"10.1101\/2020.05.01.071688"},{"key":"10.1177\/2472555220950236_bib19","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1128\/JVI.00128-13","article-title":"The Spike Protein of the Emerging Betacoronavirus EMC Uses a Novel Coronavirus Receptor for Entry, Can Be Activated by TMPRSS2, and Is Targeted by Neutralizing Antibodies","volume":"87","author":"Gierer","year":"2013","journal-title":"J. Virol."},{"key":"10.1177\/2472555220950236_bib20","doi-asserted-by":"crossref","first-page":"15214","DOI":"10.1073\/pnas.1407087111","article-title":"Host Cell Entry of Middle East Respiratory Syndrome Coronavirus after Two-Step, Furin-Mediated Activation of the Spike Protein","volume":"111","author":"Mille","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555220950236_bib21","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.antiviral.2013.09.028","article-title":"Proteolytic Activation of the SARS-Coronavirus Spike Protein: Cutting Enzymes at the Cutting Edge of Antiviral Research","volume":"100","author":"Simmons","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1177\/2472555220950236_bib22","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1021\/acs.jproteome.0c00129","article-title":"Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1","volume":"19","author":"Zhang","year":"2020","journal-title":"J. Proteome Res."},{"key":"10.1177\/2472555220950236_bib23","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1128\/JVI.78.11.5913-5922.2004","article-title":"Intracellular Targeting Signals Contribute to Localization of Coronavirus Spike Proteins Near the Virus Assembly Site","volume":"78","author":"Lontok","year":"2004","journal-title":"J. Virol."},{"key":"10.1177\/2472555220950236_bib24","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1083\/jcb.105.3.1205","article-title":"A Specific Transmembrane Domain of a Coronavirus E1 Glycoprotein Is Required for its Retention in the Golgi Region","volume":"105","author":"Machamer","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1177\/2472555220950236_bib25","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1128\/JVI.72.8.6838-6850.1998","article-title":"Coronavirus Particle Assembly: Primary Structure Requirements of the Membrane Protein","volume":"72","author":"de Haan","year":"1998","journal-title":"J. Virol."},{"key":"10.1177\/2472555220950236_bib26","doi-asserted-by":"crossref","first-page":"4967","DOI":"10.1128\/JVI.74.11.4967-4978.2000","article-title":"Assembly of the Coronavirus Envelope: Homotypic Interactions between the M Proteins","volume":"74","author":"de Haan","year":"2000","journal-title":"J. Virol."},{"key":"10.1177\/2472555220950236_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-0-387-33012-9_29","article-title":"Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly","volume":"581","author":"Masters","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1177\/2472555220950236_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0065-3527(05)64006-7","article-title":"Molecular Interactions in the Assembly of Coronaviruses","volume":"64","author":"de Haan","year":"2005","journal-title":"Adv. Virus Res."},{"key":"10.1177\/2472555220950236_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2020.03.005","article-title":"COVID-19 Infection: Origin, Transmission, and Characteristics of Human Coronaviruses","volume":"24","author":"Shereen","year":"2020","journal-title":"J. Adv. Res."},{"key":"10.1177\/2472555220950236_bib30","series-title":"StatPearls [Internet]","article-title":"Features, Evaluation and Treatment Coronavirus (COVID-19)","author":"Cascella","year":"2020"},{"key":"10.1177\/2472555220950236_bib31","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/ije\/dyaa033","article-title":"The SARS, MERS and Novel Coronavirus (COVID-19) Epidemics, the Newest and Biggest Global Health Threats: What Lessons Have We Learned?","volume":"49","author":"Peeri","year":"2020","journal-title":"Int. J. Epidemiol."},{"key":"10.1177\/2472555220950236_bib32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.antiviral.2013.08.015","article-title":"From SARS to MERS, 10 Years of Research on Highly Pathogenic Human Coronaviruses","volume":"100","author":"Hilgenfeld","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1177\/2472555220950236_bib33","first-page":"467","article-title":"MERS-CoV Incidence in the Kingdom of Saudi Arabia and Worldwide: General Review Article","volume":"47","author":"Shrwani","year":"2017","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1177\/2472555220950236_bib34","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/jmv.25748","article-title":"Unique Epidemiological and Clinical Features of the Emerging 2019 Novel Coronavirus Pneumonia (COVID-19) Implicate Special Control Measures","volume":"92","author":"Wang","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1177\/2472555220950236_bib35","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/nsr\/nwaa036","article-title":"On the Origin and Continuing Evolution of SARS-CoV-2","volume":"7","author":"Tang","year":"2020","journal-title":"Natl. Sci. Rev."},{"key":"10.1177\/2472555220950236_bib36","article-title":"COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism","author":"Liu","year":"2020","journal-title":"ChemRxiv"},{"key":"10.1177\/2472555220950236_bib37","first-page":"44","article-title":"The Proximal Origin of SARS-CoV-2","volume":"89","author":"Andersen","year":"2020","journal-title":"Nat. Med."},{"key":"10.1177\/2472555220950236_bib38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12985-015-0422-1","article-title":"Bat Origin of Human Coronaviruses","volume":"12","author":"Hu","year":"2015","journal-title":"Virol. J."},{"key":"10.1177\/2472555220950236_bib39","first-page":"e7276","article-title":"Coronavirus Disease: A Review of a New Threat to Public Health","volume":"12","author":"Ramphul","year":"2020","journal-title":"Cureus"},{"key":"10.1177\/2472555220950236_bib40","doi-asserted-by":"crossref","unstructured":"Tahir M., Alqahtani M., Alamri A.; et al. Structural Basis of SARS-CoV-2 3CL Pro and Anti-COVID-19 Drug Discovery from Medicinal Plants. J. Pharm. Anal. 2020. DOI: 10.1016\/j.jpha.2020.03.009.","DOI":"10.1016\/j.jpha.2020.03.009"},{"key":"10.1177\/2472555220950236_bib41","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/22221751.2020.1719902","article-title":"Genomic Characterization of the 2019 Novel Human-Pathogenic Coronavirus Isolated from a Patient with Atypical Pneumonia after Visiting Wuhan","volume":"9","author":"Chan","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1177\/2472555220950236_bib42","unstructured":"Werf S., Nicolas E., Bernadette C.; et al. Novel Strain of SARS-Associated Coronavirus and Applications Thereof. Google Patents. 2010. https:\/\/patents.google.com\/patent\/US20070128224A1\/en."},{"key":"10.1177\/2472555220950236_bib43","first-page":"11","article-title":"The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak\u2014An Update On the Status","volume":"7","author":"Guo","year":"2020","journal-title":"Mil. Med. Res."},{"key":"10.1177\/2472555220950236_bib44","doi-asserted-by":"crossref","unstructured":"Nezhad S., Mosaddeghi P., Negahdaripour M.; et al. Therapeutic Approaches for COVID-19 Based on the Dynamics of Interferon-Mediated Immune Responses. https:\/\/www.preprints.org\/manuscript\/202003.0206\/v1 (accessed Aug 3, 2020).","DOI":"10.2174\/1574362416666210120104636"},{"key":"10.1177\/2472555220950236_bib45","first-page":"200490","article-title":"Coronavirus Disease 2019 (COVID-19): A Perspective from China","volume":"2019","author":"Zu","year":"2020","journal-title":"Radiology"},{"key":"10.1177\/2472555220950236_bib46","doi-asserted-by":"crossref","first-page":"105924","DOI":"10.1016\/j.ijantimicag.2020.105924","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-2019 (COVID-19): The Epidemic and the Challenges","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1177\/2472555220950236_bib47","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/S2213-2600(20)30117-X","article-title":"Sex Difference and Smoking Predisposition in Patients with COVID-19","volume":"8","author":"Cai","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1177\/2472555220950236_bib48","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/S2213-2600(20)30116-8","article-title":"Are Patients with Hypertension and Diabetes Mellitus at Increased Risk for COVID-19 Infection?","volume":"8","author":"Fang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1177\/2472555220950236_bib49","doi-asserted-by":"crossref","unstructured":"Oliveiros B., Caramelo L., Ferreira C. Role of Temperature and Humidity in the Modulation of the Doubling Time of COVID-19 Cases. medRxiv. 2020. DOI: 10.1101\/2020.03.05.20031872.","DOI":"10.1101\/2020.03.05.20031872"},{"key":"10.1177\/2472555220950236_bib50","doi-asserted-by":"crossref","unstructured":"Mohammad S., Parham H., Augustin V.; et al. Spread of SARS-CoV-2 Coronavirus Likely to be Constrained by Climate. medRxiv. 2020. DOI: 10.1101\/2020.03.12.20034728.","DOI":"10.1101\/2020.03.12.20034728"},{"key":"10.1177\/2472555220950236_bib51","doi-asserted-by":"crossref","unstructured":"Sajadi M., Habibzadeh P., Vintzileos A.; et al. Temperature, Humidity, and Latitude Analysis to Predict Potential Spread and Seasonality for COVID-19. https:\/\/papers.ssrn.com\/sol3\/papers.cfm?abstract_id=3550308 (accessed Aug 3, 2020).","DOI":"10.2139\/ssrn.3550308"},{"key":"10.1177\/2472555220950236_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41421-020-0147-1","article-title":"Comparative Genetic Analysis of the Novel Coronavirus (2019-nCoV\/SARS-CoV-2) Receptor ACE2 in Different Populations","volume":"6","author":"Cao","year":"2020","journal-title":"Cell Discov."},{"key":"10.1177\/2472555220950236_bib53","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus\u2013Infected Pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1177\/2472555220950236_bib54","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(20)30360-3","article-title":"Clinical Characteristics and Intrauterine Vertical Transmission Potential of COVID-19 Infection in Nine Pregnant Women: A Retrospective Review of Medical Records","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"10.1177\/2472555220950236_bib55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/0846537120913033","article-title":"CT Imaging and Differential Diagnosis of COVID-19","volume":"71","author":"Dai","year":"2020","journal-title":"Can. Assoc. Radiol. J."},{"key":"10.1177\/2472555220950236_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2214\/AJR.20.22954","article-title":"Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management","volume":"214","author":"Li","year":"2020","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1177\/2472555220950236_bib57","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3348\/kjr.2020.0132","article-title":"Chest Radiographic and CT Findings of the 2019 Novel Coronavirus Disease (COVID-19): Analysis of Nine Patients Treated in Korea","volume":"21","author":"Yoon","year":"2020","journal-title":"Korean J. Radiol."},{"key":"10.1177\/2472555220950236_bib58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/2225-4110.124335","article-title":"Antiviral Natural Products and Herbal Medicines","volume":"4","author":"Lin","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1177\/2472555220950236_bib59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11655-020-3192-6","article-title":"Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs","volume":"26","author":"Luo","year":"2020","journal-title":"Chin. J. Integr. Med."},{"key":"10.1177\/2472555220950236_bib60","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/microorganisms8070970","article-title":"Microbial Natural Products as Potential Inhibitors of SARS-CoV-2 Main Protease (Mpro)","volume":"8","author":"Sayed","year":"2020","journal-title":"Microorganisms"},{"issue":"1","key":"10.1177\/2472555220950236_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgeb.2018.01.006","article-title":"Omics Based Approach for Biodiscovery of Microbial Natural Products in Antibiotic Resistance Era","volume":"16","author":"Mohana","year":"2018","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1177\/2472555220950236_bib62","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/2156587216641831","article-title":"Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies","volume":"22","author":"Mousa","year":"2017","journal-title":"J. Evid. Based Complementary Altern. Med."},{"key":"10.1177\/2472555220950236_bib63","first-page":"420","article-title":"Natural Products as Reservoirs of Novel Therapeutic Agents","volume":"17","author":"Mushtaq","year":"2018","journal-title":"EXCLI J."},{"issue":"2","key":"10.1177\/2472555220950236_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.23812\/CONTI-E","article-title":"Induction of Pro-Inflammatory Cytokines (IL-1 and IL-6) and Lung Inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-Inflammatory Strategies","volume":"34","author":"Conti","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1177\/2472555220950236_bib65","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/jmv.24138","article-title":"Induction of Interleukin-1 Beta (IL-1\u03b2) Is a Critical Component of Lung Inflammation during Influenza A (H1N1) Virus Infection","volume":"87","author":"Kim","year":"2015","journal-title":"J. Med. Virol."},{"key":"10.1177\/2472555220950236_bib66","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/22221751.2020.1746199","article-title":"Hypothesis for Potential Pathogenesis of SARS-CoV-2 Infection\u2014A Review of Immune Changes in Patients with Viral Pneumonia","volume":"9","author":"Lin","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1177\/2472555220950236_bib67","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1128\/JVI.79.2.884-895.2005","article-title":"Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia","volume":"79","author":"Woo","year":"2005","journal-title":"J. Virol."},{"key":"10.1177\/2472555220950236_bib68","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1076\/phbi.41.2.107.14240","article-title":"Antiviral Activity of Compounds Isolated from Plants","volume":"41","author":"Perez","year":"2003","journal-title":"Pharm. Biol."},{"key":"10.1177\/2472555220950236_bib69","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/ptr.1163","article-title":"Antiviral Potency of Mistletoe (Viscum album ssp. album) Extracts against Human Parainfluenza Virus Type 2 in Vero Cells","volume":"17","author":"Karag\u00f6z","year":"2003","journal-title":"Phyther. Res."},{"key":"10.1177\/2472555220950236_bib70","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1046\/j.1365-2672.2003.02026.x","article-title":"Novel Antiviral Agents: A Medicinal Plant Perspective","volume":"95","author":"Jassim","year":"2003","journal-title":"J. Appl. Microbiol."},{"key":"10.1177\/2472555220950236_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/EJMP\/2018\/39383","article-title":"In Vitro Antiviral Activity of Nauclea latifolia Root Bark Extract against the Respiratory Syncytial Virus","volume":"22","author":"Odimegwu","year":"2018","journal-title":"Eur. J. Med. Plants"},{"key":"10.1177\/2472555220950236_bib72","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3390\/v11070604","article-title":"Anti-Respiratory Syncytial Virus Activity of Plantago asiatica and Clerodendrum trichotomum Extracts In Vitro and In Vivo","volume":"11","author":"Chathuranga","year":"2019","journal-title":"Viruses"},{"key":"10.1177\/2472555220950236_bib73","doi-asserted-by":"crossref","first-page":"121","DOI":"10.23902\/trkjnat.543382","article-title":"Evaluation of the Antiviral Activity of Ballota glandulosissima Hub.-Mor. & Patzak Extract against Respiratory Syncytial Virus (RSV)","volume":"20","author":"Do\u011fan","year":"2019","journal-title":"Trak. Univ. J. Nat. Sci."},{"key":"10.1177\/2472555220950236_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0210702","article-title":"Pelargonium sidoides Radix Extract EPs 7630 Reduces Rhinovirus Infection through Modulation of Viral Binding Proteins on Human Bronchial Epithelial Cells","volume":"14","author":"Roth","year":"2019","journal-title":"PLoS One."},{"key":"10.1177\/2472555220950236_bib75","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/ptr.3101","article-title":"Anti-Human Rhinovirus Activity of Gallic Acid Possessing Antioxidant Capacity","volume":"24","author":"Choi","year":"2010","journal-title":"Phyther. Res."},{"key":"10.1177\/2472555220950236_bib76","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.antiviral.2005.02.007","article-title":"Identification of Natural Compounds with Antiviral Activities against SARS-Associated Coronavirus","volume":"67","author":"Li","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1177\/2472555220950236_bib77","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jep.2008.03.018","article-title":"Immunomodulatory and Anti-SARS Activities of Houttuynia cordata","volume":"118","author":"Lau","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1177\/2472555220950236_bib78","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2004.03.003","article-title":"In Vitro Susceptibility of 10 Clinical Isolates of SARS Coronavirus to Selected Antiviral Compounds","volume":"31","author":"Chen","year":"2004","journal-title":"J. Clin. Virol."},{"key":"10.1177\/2472555220950236_bib79","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.antiviral.2007.03.003","article-title":"Plant Lectins Are Potent Inhibitors of Coronaviruses by Interfering with Two Targets in the Viral Replication Cycle","volume":"75","author":"Keyaerts","year":"2007","journal-title":"Antiviral Res."},{"key":"10.1177\/2472555220950236_bib80","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1080\/14756366.2016.1265519","article-title":"Evaluation of Polyphenols from Broussonetia papyrifera as Coronavirus Protease Inhibitors","volume":"32","author":"Park","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1177\/2472555220950236_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2253-8","article-title":"Effective Inhibition of MERS-CoV Infection by Resveratrol","volume":"17","author":"Lin","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"10.1177\/2472555220950236_bib82","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14805\/jphchem.2016.art47","article-title":"The Updates on Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Epidemiology, Pathogenesis, Viral Genome and Currently Available Drugs","volume":"3","author":"Jadav","year":"2016","journal-title":"J. Pharm. Chem."},{"key":"10.1177\/2472555220950236_bib83","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.antiviral.2005.07.002","article-title":"Anti-SARS Coronavirus 3C-Like Protease Effects of Isatis indigotica Root and Plant-Derived Phenolic Compounds","volume":"68","author":"Lin","year":"2005","journal-title":"Antiviral Res."},{"key":"10.1177\/2472555220950236_bib84","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1016\/j.bmcl.2012.04.081","article-title":"Identification of Myricetin and Scutellarein as Novel Chemical Inhibitors of the SARS Coronavirus Helicase, nsP13","volume":"22","author":"Yu","year":"2012","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"10.1177\/2472555220950236_bib85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ptr.2295","article-title":"Antiviral Effects of Glycyrrhiza species","volume":"22","author":"Cristina","year":"2008","journal-title":"Phyther. Res."},{"key":"10.1177\/2472555220950236_bib86","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0140-6736(03)13615-X","article-title":"Glycyrrhizin, an Active Component of Liquorice Roots, and Replication of SARS-Associated Coronavirus Progression of Cerebral White Matter Lesions: 6-Year Results of the Austrian Stroke Prevention Study","volume":"361","author":"Cinatl","year":"2003","journal-title":"Lancet"},{"key":"10.1177\/2472555220950236_bib87","doi-asserted-by":"crossref","unstructured":"Signer J., Jonsdottir H. R., Albrich W. C.; et al. In Vitro Antiviral Activity of Echinaforce\u00ae, an Echinacea Purpurea Preparation, against Common Cold Coronavirus 229E and Highly Pathogenic MERS-CoV and SARS-CoV. Virol. J. 2020. DOI: 10.21203\/rs.2.24724\/v1.","DOI":"10.21203\/rs.2.24724\/v2"},{"key":"10.1177\/2472555220950236_bib88","doi-asserted-by":"crossref","first-page":"14692","DOI":"10.1073\/pnas.0802675105","article-title":"Epigallocatechin-3-Gallate Inhibits IL-6 Synthesis and Suppresses Transsignaling by Enhancing Soluble gp130 Production","volume":"105","author":"Ahmed","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/2472555220950236_bib89","first-page":"2899","article-title":"Down-Regulation of Expression of Interleukin-6 and Its Receptor Results in Growth Inhibition of MCF-7 Breast Cancer cells","volume":"31","author":"Jiang","year":"2011","journal-title":"Anticancer Res."},{"key":"10.1177\/2472555220950236_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femspd\/ftw059","article-title":"Control of Autoimmune Inflammation by Celastrol, a Natural Triterpenoid","volume":"74","author":"Venkatesha","year":"2016","journal-title":"Pathog. Dis."},{"key":"10.1177\/2472555220950236_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4933-4-1","article-title":"The Interleukin-6 Inflammation Pathway from Cholesterol to Aging\u2014Role of Statins, Bisphosphonates and Plant Polyphenols in Aging and age-Related Diseases","volume":"4","author":"Omoigui","year":"2007","journal-title":"Immun. Ageing."},{"key":"10.1177\/2472555220950236_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2348968","article-title":"Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases","volume":"2016","author":"Santana","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1177\/2472555220950236_bib93","first-page":"1","article-title":"Anti-Inflammatory Effects of Herbal-Derived Factors Are Mediated by Down Regulation of Pro-Inflammatory Cytokines","volume":"2","author":"Hadieh","year":"2010","journal-title":"2nd Conf. Biotechnol. Appl. Palest."},{"key":"10.1177\/2472555220950236_bib94","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.3390\/ijms20174226","article-title":"Kaempferia parviflora Extract Inhibits STAT3 Activation and Interleukin-6 Production in HeLa Cervical Cancer Cells","volume":"20","author":"Suradej","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1177\/2472555220950236_bib95","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal Structure of SARS-CoV-2 Main Protease Provides a Basis for Design of Improved \u03b1-Ketoamide Inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science."},{"key":"10.1177\/2472555220950236_bib96","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings","volume":"64","author":"Lipinski","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1177\/2472555220950236_bib97","first-page":"1","article-title":"Fluphenazine Decanoate (Timing of Administration) for People with Schizophrenia","volume":"10","author":"Abbas","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1177\/2472555220950236_bib98","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/molecules21040416","article-title":"Sinigrin and Its Therapeutic Benefits","volume":"21","author":"Mazumder","year":"2016","journal-title":"Molecules"},{"key":"10.1177\/2472555220950236_bib99","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1076\/phbi.39.2.127.6253","article-title":"Mirazid: A New Schistosomicidal Drug","volume":"39","author":"Badria","year":"2001","journal-title":"Pharm. Biol."}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2472555220950236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/2472555220950236","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222066461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222066461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/2472555220950236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:53:16Z","timestamp":1762861996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222066461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":99,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2472555222066461"],"URL":"https:\/\/doi.org\/10.1177\/2472555220950236","relation":{},"ISSN":["2472-5552"],"issn-type":[{"type":"print","value":"2472-5552"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Based on Principles and Insights of COVID-19 Epidemiology, Genome Sequencing, and Pathogenesis: Retrospective Analysis of Sinigrin and ProlixinRX (Fluphenazine) Provides Off-Label Drug Candidates","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/2472555220950236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2020 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}