{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:43:25Z","timestamp":1790509405632,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"vor","delay-in-days":169,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003579","name":"university of toronto","doi-asserted-by":"publisher","award":["COVID-19 Action Initiative-2020"],"award-info":[{"award-number":["COVID-19 Action Initiative-2020"]}],"id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004489","name":"mitacs","doi-asserted-by":"publisher","award":["COVID-19 Mitacs Accelerate postdoctoral awards"],"award-info":[{"award-number":["COVID-19 Mitacs Accelerate postdoctoral awards"]}],"id":[{"id":"10.13039\/501100004489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["R35GM131858"],"award-info":[{"award-number":["R35GM131858"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"national institute of allergy and infectious diseases","doi-asserted-by":"publisher","award":["HHSN272201700060C"],"award-info":[{"award-number":["HHSN272201700060C"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["slas-discovery.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["SLAS Discovery"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1177\/24725552211026261","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T04:58:00Z","timestamp":1625115480000},"page":"1200-1211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"title":["Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors"],"prefix":"10.1016","volume":"26","author":[{"given":"Kanchan","family":"Devkota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Schapira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumera","family":"Perveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliakbar","family":"Khalili Yazdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Ghiabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Hajian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Loppnau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Bolotokova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla J.F.","family":"Satchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul V.","family":"Fish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-0169","authenticated-orcid":false,"given":"Masoud","family":"Vedadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1177\/24725552211026261_bib1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1177\/24725552211026261_bib2","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1007\/s00705-016-2977-6","article-title":"Ratification Vote on Taxonomic Proposals to the International Committee on Taxonomy of Viruses (2016)","volume":"161","author":"Adams","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1177\/24725552211026261_bib3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/s41564-020-0695-z","article-title":"The Species Severe Acute Respiratory Syndrome-Related Coronavirus: Classifying 2019-nCoV and Naming It SARS-CoV-2","volume":"5","year":"2020","journal-title":"Nat. Microbiol."},{"issue":"Suppl.","key":"10.1177\/24725552211026261_bib4","first-page":"S9","article-title":"SARS: Epidemiology","volume":"8","author":"Chan-Yeung","year":"2003","journal-title":"Respirology"},{"key":"10.1177\/24725552211026261_bib5","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1056\/NEJMoa1211721","article-title":"Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia","volume":"367","author":"Zaki","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1177\/24725552211026261_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/22221751.2020.1719902","article-title":"Genomic Characterization of the 2019 Novel Human-Pathogenic Coronavirus Isolated from a patient with Atypical Pneumonia after Visiting Wuhan","volume":"9","author":"Chan","year":"2020","journal-title":"Emerg. Microbes Infect."},{"key":"10.1177\/24725552211026261_bib7","doi-asserted-by":"crossref","first-page":"e00473-12","DOI":"10.1128\/mBio.00473-12","article-title":"Genomic Characterization of a Newly Discovered Coronavirus Associated with Acute Respiratory Distress Syndrome in Humans","volume":"3","author":"van Boheemen","year":"2012","journal-title":"mBio"},{"key":"10.1177\/24725552211026261_bib8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging Coronaviruses: Genome Structure, Replication, and Pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1177\/24725552211026261_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.antiviral.2014.12.015","article-title":"The SARS-Coronavirus Papain-Like Protease: Structure, Function and Inhibition by Designed Antiviral Compounds","volume":"115","author":"Baez-Santos","year":"2015","journal-title":"Antiviral Res."},{"key":"10.1177\/24725552211026261_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12250-016-3726-4","article-title":"Molecular Mechanisms of Coronavirus RNA Capping and Methylation","volume":"31","author":"Chen","year":"2016","journal-title":"Virol. Sin."},{"key":"10.1177\/24725552211026261_bib11","doi-asserted-by":"crossref","first-page":"e1000896","DOI":"10.1371\/journal.ppat.1000896","article-title":"Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing","volume":"6","author":"Eckerle","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1177\/24725552211026261_bib12","doi-asserted-by":"crossref","first-page":"9372","DOI":"10.1073\/pnas.1201130109","article-title":"RNA 3\u2032-End Mismatch Excision by the Severe Acute Respiratory Syndrome Coronavirus Nonstructural Protein Nsp10\/Nsp14 Exoribonuclease Complex","volume":"109","author":"Bouvet","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/24725552211026261_bib13","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1128\/JVI.00110-15","article-title":"Mutations in Coronavirus Nonstructural Protein 10 Decrease Virus Replication Fidelity","volume":"89","author":"Smith","year":"2015","journal-title":"J. Virol."},{"key":"10.1177\/24725552211026261_bib14","doi-asserted-by":"crossref","first-page":"E3900","DOI":"10.1073\/pnas.1323705111","article-title":"One Severe Acute Respiratory Syndrome Coronavirus Protein Complex Integrates Processive RNA Polymerase and Exonuclease Activities","volume":"111","author":"Subissi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/24725552211026261_bib15","doi-asserted-by":"crossref","first-page":"e1002059","DOI":"10.1371\/journal.ppat.1002059","article-title":"Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2\u2032-O-Methyltransferase Nsp10\/Nsp16 Complex","volume":"7","author":"Decroly","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1177\/24725552211026261_bib16","doi-asserted-by":"crossref","first-page":"e1000863","DOI":"10.1371\/journal.ppat.1000863","article-title":"In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation","volume":"6","author":"Bouvet","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1177\/24725552211026261_bib17","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1073\/pnas.0808790106","article-title":"Functional Screen Reveals SARS Coronavirus Nonstructural Protein Nsp14 as a Novel Cap N7 Methyltransferase","volume":"106","author":"Chen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1177\/24725552211026261_bib18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0092-8674(00)80280-9","article-title":"Cocrystal Structure of the Messenger RNA 5\u2032 Cap-Binding Protein (eIF4E) Bound to 7-Methyl-GDP","volume":"89","author":"Marcotrigiano","year":"1997","journal-title":"Cell"},{"key":"10.1177\/24725552211026261_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrmicro2675","article-title":"Conventional and Unconventional Mechanisms for Capping Viral mRNA","volume":"10","author":"Decroly","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1177\/24725552211026261_bib20","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.1128\/JVI.78.14.7833-7838.2004","article-title":"Human Coronavirus 229E Nonstructural Protein 13: Characterization of Duplex-Unwinding, Nucleoside Triphosphatase, and RNA 5\u2032-Triphosphatase Activities","volume":"78","author":"Ivanov","year":"2004","journal-title":"J. Virol."},{"key":"10.1177\/24725552211026261_bib21","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1128\/JVI.78.11.5619-5632.2004","article-title":"Multiple Enzymatic Activities Associated with Severe Acute Respiratory Syndrome Coronavirus Helicase","volume":"78","author":"Ivanov","year":"2004","journal-title":"J. Virol."},{"key":"10.1177\/24725552211026261_bib22","doi-asserted-by":"crossref","first-page":"8071","DOI":"10.1128\/JVI.00407-08","article-title":"Coronavirus Nonstructural Protein 16 Is a Cap-0 Binding Enzyme Possessing (Nucleoside-2\u2032O)-Methyltransferase Activity","volume":"82","author":"Decroly","year":"2008","journal-title":"J. Virol."},{"key":"10.1177\/24725552211026261_bib23","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/bs.aivir.2018.01.001","article-title":"Hosts and Sources of Endemic Human Coronaviruses","volume":"100","author":"Corman","year":"2018","journal-title":"Adv. Virus Res."},{"key":"10.1177\/24725552211026261_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/24725552211026261_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41467-018-07905-4","article-title":"A Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling","volume":"10","author":"Scheer","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1177\/24725552211026261_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10822-012-9547-0","article-title":"Docking and Scoring with ICM: The Benchmarking Results and Strategies for Improvement","volume":"26","author":"Neves","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1177\/24725552211026261_bib27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1021\/ci100479z","article-title":"Structural Chemistry of the Histone Methyltransferases Cofactor Binding Site","volume":"51","author":"Campagna-Slater","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1177\/24725552211026261_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.antiviral.2012.07.007","article-title":"The Viral RNA Capping Machinery as a Target for Antiviral Drugs","volume":"96","author":"Ferron","year":"2012","journal-title":"Antiviral Res."},{"key":"10.1177\/24725552211026261_bib29","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.3390\/molecules24244492","article-title":"Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor","volume":"24","author":"Ferreira","year":"2019","journal-title":"Molecules"},{"key":"10.1177\/24725552211026261_bib30","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1182\/blood-2017-12-818948","article-title":"The DOT1L Inhibitor Pinometostat Reduces H3K79 Methylation and Has Modest Clinical Activity in Adult Acute Leukemia","volume":"131","author":"Stein","year":"2018","journal-title":"Blood"},{"key":"10.1177\/24725552211026261_bib31","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S1470-2045(20)30451-4","article-title":"Tazemetostat in Advanced Epithelioid Sarcoma with Loss of INI1\/SMARCB1: An International, Open-Label, Phase 2 Basket Study","volume":"21","author":"Gounder","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1177\/24725552211026261_bib32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4939-3673-1_3","article-title":"High-Throughput Screening Using Mass Spectrometry within Drug Discovery","volume":"1439","author":"Rohman","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1177\/24725552211026261_bib33","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/1087057115608605","article-title":"The Evolution of MALDI-TOF Mass Spectrometry toward Ultra-High-Throughput Screening: 1536-Well Format and Beyond","volume":"21","author":"Haslam","year":"2016","journal-title":"J. Biomol. Screen."},{"key":"10.1177\/24725552211026261_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/2472630318791981","article-title":"Automated MALDI Target Preparation Concept: Providing Ultra-High-Throughput Mass Spectrometry-Based Screening for Drug Discovery","volume":"24","author":"Winter","year":"2019","journal-title":"SLAS Technol."},{"key":"10.1177\/24725552211026261_bib35","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.chembiol.2014.07.015","article-title":"Screening Technologies for Small Molecule Discovery: The State of the Art","volume":"21","author":"Janzen","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1177\/24725552211026261_bib36","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ncomms2304","article-title":"Catalytic Site Remodelling of the DOT1L Methyltransferase by Selective Inhibitors","volume":"3","author":"Yu","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1177\/24725552211026261_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ccr.2011.06.009","article-title":"Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor","volume":"20","author":"Daigle","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1177\/24725552211026261_bib38","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1021\/cb400133j","article-title":"An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1","volume":"8","author":"Konze","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1177\/24725552211026261_bib39","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1021\/acs.jmedchem.9b00112","article-title":"Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase","volume":"62","author":"Taylor","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1177\/24725552211026261_bib40","doi-asserted-by":"crossref","first-page":"112557","DOI":"10.1016\/j.ejmech.2020.112557","article-title":"Synthesis of Adenine Dinucleosides SAM Analogs as Specific Inhibitors of SARS-CoV Nsp14 RNA Cap Guanine-N7-Methyltransferase","volume":"201","author":"Ahmed-Belkacem","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1177\/24725552211026261_bib41","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1016\/j.bmcl.2016.07.041","article-title":"New Small Molecule Inhibitors of Histone Methyl Transferase DOT1L with a Nitrile as a Non-Traditional Replacement for Heavy Halogen Atoms","volume":"26","author":"Spurr","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1177\/24725552211026261_bib42","doi-asserted-by":"crossref","first-page":"e47110","DOI":"10.7554\/eLife.47110","article-title":"A Chemical Probe of CARM1 Alters Epigenetic Plasticity against Breast Cancer Cell Invasion","volume":"8","author":"Cai","year":"2019","journal-title":"Elife"},{"key":"10.1177\/24725552211026261_bib43","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/acs.jmedchem.7b01422","article-title":"Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)","volume":"61","author":"Babault","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1177\/24725552211026261_bib44","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.3882","article-title":"Nicotinamide N-Methyltransferase Regulates Hepatic Nutrient Metabolism through Sirt1 Protein Stabilization","volume":"21","author":"Hong","year":"2015","journal-title":"Nat. Med."}],"container-title":["SLAS Discovery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24725552211026261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24725552211026261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222067582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2472555222067582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24725552211026261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:55:30Z","timestamp":1762862130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2472555222067582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2472555222067582"],"URL":"https:\/\/doi.org\/10.1177\/24725552211026261","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.19.424337","asserted-by":"object"}]},"ISSN":["2472-5552"],"issn-type":[{"value":"2472-5552","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors","name":"articletitle","label":"Article Title"},{"value":"SLAS Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1177\/24725552211026261","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2021 Society for Laboratory Automation and Screening. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}