{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:05:46Z","timestamp":1793325946599,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":62,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"novartis pharmaceuticals corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the clinical and health care burden of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective, cross\u2010sectional design with analyses of patient visits from 2 databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>National Ambulatory Medical Care Survey (NAMCS, 2012\u20102016) and State Ambulatory Surgery and Services Databases (SASD, 2012\u20102015) in available states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In each analysis, we identified patients (\u226518 years old) with a diagnosis of CRSwNP (<jats:italic>ICD\u20109\u2010CM<\/jats:italic>: 471.x; <jats:italic>ICD\u201010\u2010CM<\/jats:italic>: J33.x) in the visit record during the study period. CRS patients without polyps (CRSsNP: <jats:italic>ICD\u20109\u2010CM<\/jats:italic>: 473.x, <jats:italic>ICD\u201010\u2010CM<\/jats:italic>: J32.x; without CRSwNP codes) were identified for comparison. In the SASD, we focused on visits involving relevant sinus procedures. Outcomes included comorbidities, diagnostic testing, and prescribed medication (NAMCS) and surgery visit characteristics (SASD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 2272\u00a0NAMCS records from physician offices (183 CRSwNP, 2089 CRSsNP). Most visits were for patients aged &lt;65 years (78.8%, 80.6%) and privately insured (67.7%, 61.5%); CRSwNP visits had a male majority (56.3%, 35.4%). CRSwNP vs CRSsNP visits more often reported asthma (40.2%, 10.3%), allergic rhinitis (14.0%, 8.7%), and congestion (22.0%, 21.1%), with the use of glucocorticoids (21.0%, 17.7%) and nasal allergy medication (26.2%, 10.2%). In the SASD, 427,306 surgery visits were identified (71,195 CRSwNP, 356,111 CRSsNP); demographics were similar to NAMCS. CRSwNP surgeries involved more sinus types (59.3%, 41.4%). Surgeries were mostly elective (&gt;99%) and completed quickly (&lt;2 hours), without perioperative complications (&gt;99%), followed by routine discharge (&gt;91%); follow\u2010up visits were common (14.9%, 13.9%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CRSwNP compared to CRSsNP patients have a distinct clinical experience, with moderately higher medication need and more extensive surgery.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2473974x20950727","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T14:42:09Z","timestamp":1598971329000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Burden of Nasal Polyps in the United States"],"prefix":"10.1002","volume":"4","author":[{"given":"Elisabeth H.","family":"Ference","sequence":"first","affiliation":[{"name":"Caruso Department of Otolaryngology Keck School of Medicine of the University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila R.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC Beverly Hills California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Tieu","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC Beverly Hills California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohum","family":"Gokhale","sequence":"additional","affiliation":[{"name":"Partnership for Health Analytic Research, LLC Beverly Hills California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Health Services Research University of Maryland School of Pharmacy Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"LeCocq","sequence":"additional","affiliation":[{"name":"Novartis Pharmaceuticals East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","article-title":"Epidemiologie der chronischen Rhinosinusitis, ausgew\u00e4hlter Risikofaktoren und Komorbidit\u00e4ten, und ihre \u00f6konomischen Folgen","volume":"94","author":"Beule 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