{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:29:02Z","timestamp":1791916142528,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Aerin Medical Inc"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the safety and efficacy of temperature\u2010controlled radiofrequency (RF) neurolysis of the posterior nasal nerve (PNN) area for the treatment of chronic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A multicenter, prospective, single\u2010blinded, randomized controlled trial, in which the control arm underwent a sham procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Sixteen otolaryngology centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with 24\u2010hour reflective Total Nasal Symptom Score (rTNSS) \u22656, including moderate to severe rhinorrhea and mild to severe congestion, were randomized 2:1 to active treatment of the posterior nasal nerve area with a temperature\u2010controlled RF device or a sham procedure, with no RF energy delivery. The stylus was applied bilaterally to nonoverlapping areas of the posterior middle meatus and posterior inferior turbinate in each nostril in the region of the PNN. The primary endpoint was responder rate at 3\u00a0months, where a response was defined as \u226530% improvement (decrease) in rTNSS from baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients had a mean baseline rTNSS of 8.3 (95% CI, 7.9\u20108.7) and 8.2 (95% CI, 7.6\u20108.8) (<jats:italic>P<\/jats:italic> =. 797) in the active treatment (n = 77) and sham control (n = 39) arms, respectively. At 3\u00a0months, responder rate was significantly higher in the active treatment arm: 67.5% (95% CI, 55.9%\u201077.8%) vs 41.0% (95% CI, 25.6%\u201057.9%) (<jats:italic>P<\/jats:italic> =. 009). The active treatment arm had a significantly greater decrease in rTNSS (mean, \u22123.6 [95% CI, \u22124.2 to \u22123.0] vs \u22122.2 [95% CI, \u22123.2 to \u22121.3]) (<jats:italic>P<\/jats:italic> =. 013). Three adverse events related to the device\/procedure were reported, and all resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This randomized controlled trial showed temperature\u2010controlled neurolysis of the PNN area is free from significant adverse events and superior to a sham procedure in decreasing the symptom burden of chronic rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2473974x211041124","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T14:15:58Z","timestamp":1631283358000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Effect of Radiofrequency Neurolysis on the Symptoms of Chronic Rhinitis: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"5","author":[{"given":"J. Pablo","family":"Stolovitzky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Ow","sequence":"additional","affiliation":[{"name":"Sacramento Ear Nose and Throat Medical and Surgical Group Roseville California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey L.","family":"Silvers","sequence":"additional","affiliation":[{"name":"Madison ENT &amp; Facial Plastic Surgery New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim B.","family":"Bikhazi","sequence":"additional","affiliation":[{"name":"The Ogden Clinic Ogden Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"ENT and Allergy Associates of Florida Plantation Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head &amp; Neck Surgery Houston Methodist Hospital Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otot.2007.05.010"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1907862"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21991"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.28301"},{"key":"e_1_2_10_6_1","article-title":"Multiple site cryoablation treatment of the posterior nasal nerve for treatment of chronic rhinitis: an observational feasibility study","author":"Yen DM","journal-title":"Allergy Rhinol"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102396"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-0914-y"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00022"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00016"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.247"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22667"},{"key":"e_1_2_10_13_1","volume-title":"AHRQ Comparative Effectiveness Reviews","author":"Glacy J","year":"2013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-010-0093-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0636-3"},{"issue":"105","key":"e_1_2_10_16_1","first-page":"203","article-title":"The effect of gelfoam impregnated with botulinum toxin on allergic rhinitis","volume":"31","author":"Zand V","year":"2019","journal-title":"Iran J Otorhinolaryngol"}],"container-title":["OTO Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2473974X211041124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1177\/2473974X211041124","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/2473974X211041124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:42:44Z","timestamp":1760971364000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1177\/2473974X211041124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1177\/2473974X211041124"],"URL":"https:\/\/doi.org\/10.1177\/2473974x211041124","archive":["Portico"],"relation":{},"ISSN":["2473-974X","2473-974X"],"issn-type":[{"value":"2473-974X","type":"print"},{"value":"2473-974X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"article-number":"2473974X211041124"}}