{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:12:54Z","timestamp":1793394774853,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"GSK","award":["206770"],"award-info":[{"award-number":["206770"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["OTO Open"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize healthcare burden, treatment patterns, and clinical characteristics associated with chronic rhinosinusitis with nasal polyps (CRSwNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Retrospective cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Real\u2010world study using US health insurance claims database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with \u22651 CRSwNP diagnosis (index date: first claim for nasal polyps [NPs] between January 1, 2008, and March 31, 2019) and continuous health insurance coverage for \u2265180\u00a0days preindex (baseline) and postindex were included. Follow\u2010up spanned from index to the earliest of disenrollment, death, or data end. Assessments included patient demographics, comorbidities, and blood eosinophil count at baseline, healthcare resource utilization (HCRU), and costs during follow\u2010up in the overall population and stratified by number of surgeries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 119,357 patients who met the inclusion criteria, 33,748 (28%) had \u22651 surgery during follow\u2010up, among whom 3262 (9.7%) had \u22652 surgeries. At baseline, patients with \u22651 vs no NP surgeries had a greater comorbidity burden; a higher proportion of patients had comorbid asthma (37.8% vs 21.8%) and blood eosinophil count \u2265300 cells\/\u00b5L (42.6% vs 38.1%). During follow\u2010up, patients with NP surgeries had higher all\u2010cause and CRSwNP\u2010related HCRU and costs than patients without NP surgery. All\u2010cause healthcare costs per person per year increased with the number of surgeries during follow\u2010up (no surgery, $10,628; \u22651 surgery, $20,747; \u22652 surgeries, $26,969).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with CRSwNP and surgery had a greater disease burden than those without surgery, with higher HCRU and costs, and were more likely to have comorbid conditions (most commonly asthma) and elevated blood eosinophil count, indicating a subset of patients with recalcitrant CRSwNP.<\/jats:p><\/jats:sec>","DOI":"10.1177\/2473974x221128930","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T09:44:30Z","timestamp":1665395070000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Elucidating the Real\u2010World Burden of Chronic Rhinosinusitis With Nasal Polyps in Patients in the USA"],"prefix":"10.1002","volume":"6","author":[{"given":"Victoria S.","family":"Benson","sequence":"first","affiliation":[{"name":"Epidemiology Value Evidence and Outcomes GSK Brentford Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Germain","sequence":"additional","affiliation":[{"name":"Groupe d\u2019analyse Lt\u00e9e Montr\u00e9al, QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Chan","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Respiratory GSK Brentford Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Respiratory GSK Brentford Middlesex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibing","family":"Yang","sequence":"additional","affiliation":[{"name":"Value Evidence and Outcomes GSK Collegeville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Silver","sequence":"additional","affiliation":[{"name":"US Medical Affairs\u2013Respiratory GSK Research Triangle Park North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Sheng","family":"Duh","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc. 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