{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:16Z","timestamp":1790697856340,"version":"4.1.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This work aims to determine whether previously defined genotype risk groups interact with Age-Related Eye Disease Study formulation (AREDS-F) use in progression to neovascular age-related macular degeneration (nvAMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a case-only study of 265 nvAMD patients. Patients were anonymously genotyped at the complement factor H and age-related maculopathy susceptibility 2 loci and segregated into genotype groups (GTGs) defined by specific combinations of risk alleles. Physicians, who were blind to patients\u2019 GTGs, obtained patients\u2019 AREDS-F use history. The facility performing genetic analysis was blind to the AREDS-F use history. We used logistic analysis to estimate the interaction coefficient between AREDS-F use and GTG 2 vs GTG 3 in a general-population model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The odds ratio of numbers of patients reporting prior AREDS-F use to nonuse for GTG 2 vs GTG 3 was 4.18 ( P\u2009=\u2009.001). Logistic regression, correcting for nongenetic risk factors, gave an estimate of the \u03b2 for interaction of AREDS-F with genotype of 1.57 ( P\u2009=\u2009.001). This estimates a corrected odds ratio associated with the effect of interaction of 4.81 between those in GTG 2 compared with those in GTG 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our data indicate an interaction between GTGs and AREDS-F use that is consistent in size and direction with previously published reports, which had found that using AREDS-F supplements significantly increases the risk of nvAMD for some users and significantly protects other users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2474126420941713","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T07:47:50Z","timestamp":1597823270000},"page":"46-52","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetics and Age-Related Eye Disease Study Formulation Interaction in Neovascular Age-Related Macular Degeneration"],"prefix":"10.1177","volume":"5","author":[{"given":"Stephen R.","family":"Kaufman","sequence":"first","affiliation":[{"name":"Vitreo-Retinal Consultants, Canton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-4297","authenticated-orcid":false,"given":"Pradeepa","family":"Yoganathan","sequence":"additional","affiliation":[{"name":"Kresge Eye Institute, Wayne State University, Detroit, MI, USA"},{"name":"Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada"},{"name":"Laurel Eye Clinic, Brookville, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent W.","family":"Small","sequence":"additional","affiliation":[{"name":"Macula and Retina Institute, Glendale, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepam","family":"Rusia","sequence":"additional","affiliation":[{"name":"Vitreo-Retinal Consultants, Canton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia I.","family":"Pachydaki","sequence":"additional","affiliation":[{"name":"Vitreo-Retinal Consultants, Canton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Conti","sequence":"additional","affiliation":[{"name":"Vitreo-Retinal Consultants, Canton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Wenz","sequence":"additional","affiliation":[{"name":"Vitreo-Retinal Consultants, Canton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Gersman","sequence":"additional","affiliation":[{"name":"Vitreo-Retinal Consultants, Canton, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi S.","family":"Shaya","sequence":"additional","affiliation":[{"name":"Macula and Retina Institute, Glendale, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Kustra","sequence":"additional","affiliation":[{"name":"Dana Lana School of Public Health, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"bibr1-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1186\/s40662-016-0063-5"},{"key":"bibr2-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0801537"},{"key":"bibr3-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.10.1417"},{"key":"bibr4-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.04.029"},{"key":"bibr5-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.10.022"},{"key":"bibr6-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.16.1793"},{"key":"bibr7-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8657"},{"key":"bibr8-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.021"},{"key":"bibr9-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.07.049"},{"key":"bibr10-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.07.039"},{"key":"bibr11-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.01.036"},{"key":"bibr12-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-308624"},{"key":"bibr13-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1718059115"},{"key":"bibr14-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.008"},{"key":"bibr15-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.09.008"},{"key":"bibr16-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.10.023"},{"key":"bibr17-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.024"},{"key":"bibr18-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.12.018"},{"key":"bibr19-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.04.012"},{"key":"bibr20-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780130206"},{"key":"bibr21-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4997"},{"key":"bibr22-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1038\/ng.170"},{"key":"bibr23-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2980"},{"key":"bibr24-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.10.030"},{"key":"bibr25-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.605691"},{"key":"bibr26-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.476143"},{"key":"bibr27-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.03.006"},{"key":"bibr28-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.09.023"},{"key":"bibr29-2474126420941713","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1941.00870100042005"}],"container-title":["Journal 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