{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:51:18Z","timestamp":1791049878410,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study determines whether fluorescein angiography (FA) with a 250-mg dose of fluorescein (half dose) is equal in quality to the standard 500-mg dose of fluorescein (full dose) when using digital ultra-widefield (UWF) technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In a randomized, prospective study using a UWF imaging system, FAs performed with half dose were compared with angiograms performed with full dose. Imaging studies were reviewed by 4 reviewers based on 6 characteristics: dye transit, macrovasculature, macula detail, microvasculature, leakage, and overall quality. The scores for macrovasculature, macula detail, microvasculature, and overall quality were converted to a fuzzy rating score to confirm results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-nine FAs from 67 patients were reviewed for this study, including 12 patients who had both half-dose and full-dose FAs. Of all the factors studied, only microvasculature received a significantly different score between full dose and half dose that was confirmed by the fuzzy rating scale (3.79 vs 3.53; P\u2009=\u2009.04). Among those eyes that received both full and half dose, there was no significant difference in any of the 6 factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In a UWF imaging system, aside from looking at fine microvascular abnormalities, the 250-mg dose of fluorescein provided similar results to a 500-mg dose. The images were not significantly different in overall quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/2474126420975310","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T18:21:40Z","timestamp":1610562100000},"page":"337-344","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Randomized, Comparative Study of Full- and Half-Dose Fluorescein Angiography"],"prefix":"10.1177","volume":"5","author":[{"given":"Vaama","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Syeda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Zeiter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariman","family":"Nassiri","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaesik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Truhan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Parendo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mack","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Visual and Anatomic Sciences and the Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"bibr1-2474126420975310","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.24.1.82"},{"issue":"1","key":"bibr2-2474126420975310","first-page":"6","volume":"5","author":"Alvis DL","year":"1982","journal-title":"J Ophthalmic Photogr"},{"key":"bibr3-2474126420975310","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.12.010"},{"key":"bibr4-2474126420975310","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20080701-06"},{"key":"bibr5-2474126420975310","volume-title":"Fluorescein Angiography of the Retina; 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