{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:15Z","timestamp":1790697915796,"version":"4.1.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This is the first report to our knowledge of ischemic retinopathy in a pediatric patient with Upshaw-Schulman syndrome (USS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 6-year-old girl previously diagnosed with USS was referred to our clinic with exodeviation of the left eye and a 2-month-long decrease in vision of both eyes. A dilated fundus examination showed a total vitreous hemorrhage in both eyes. The first course of action was conservative treatment, with the patient experiencing visual-acuity improvement in her right eye.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>An ischemic retina and optic nerve atrophy was found once the left eye was cleared of the hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We present a case of a vitreous hemorrhage, possibly secondary to an episode of severe thrombocytopenia. Following USS diagnosis, providers should perform dilated ophthalmologic examinations as part of initial and follow-up general evaluations. This case exemplifies that, in understudied and underdescribed pediatric retinal diseases, extreme therapeutic decisions\u2014such as surgery\u2014should not be rushed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/24741264211049694","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T23:25:17Z","timestamp":1634858717000},"page":"163-166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral Ischemic Retinopathy Associated With Upshaw-Schulman Syndrome: A Case Report"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0356-697X","authenticated-orcid":false,"given":"Mariam","family":"Cernichiaro-Espinosa","sequence":"first","affiliation":[{"name":"Pediatric Retina Unit, Retina and Vitreous Department, Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico, I.A.P. Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Meizner-Grezemkovsky","sequence":"additional","affiliation":[{"name":"Pediatric Retina Unit, Retina and Vitreous Department, Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico, I.A.P. Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"L\u00f3pez-Santiago","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hemathology Department, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Borbolla-Pertierra","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hemathology Department, Instituto Nacional de Pediatr\u00eda, Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virgilio","family":"Morales-Cant\u00f3n","sequence":"additional","affiliation":[{"name":"Pediatric Retina Unit, Retina and Vitreous Department, Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico, I.A.P. Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Cernichiaro-Espinosa","sequence":"additional","affiliation":[{"name":"Pediatric Retina Unit, Retina and Vitreous Department, Asociaci\u00f3n para Evitar la Ceguera en M\u00e9xico, I.A.P. Ciudad de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"issue":"1","key":"bibr1-24741264211049694","first-page":"39","volume":"221","author":"Lehmberg K","year":"2017","journal-title":"Z Geburtshilfe Neonatol"},{"key":"bibr2-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(10)80149-2"},{"key":"bibr3-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2018.10.023"},{"key":"bibr4-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.09.004"},{"key":"bibr5-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1186\/2052-1839-14-16"},{"key":"bibr6-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001226"},{"issue":"3","key":"bibr7-24741264211049694","first-page":"197","volume":"7","author":"Richa VAR","year":"2018","journal-title":"New Indian Journal of Pediatrics"},{"key":"bibr8-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2011.10.027"},{"key":"bibr9-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2004.00623.x"},{"key":"bibr10-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000727"},{"key":"bibr11-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1177\/2474126417749390"},{"key":"bibr12-24741264211049694","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14409"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264211049694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264211049694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264211049694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:25:27Z","timestamp":1790695527000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264211049694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/24741264211049694"],"URL":"https:\/\/doi.org\/10.1177\/24741264211049694","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]}}}