{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:42Z","timestamp":1790697882637,"version":"4.1.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Purpose: Systemic amyloidosis is a group of rare, life-threatening disorders characterized by the deposition of amyloid plaques in numerous tissues. Vitreous involvement can occur in amyloidosis and here we describe critical diagnostic findings. Methods: Case report of vitreous amyloidosis diagnosis confounded by non-specific presentation. Results: Despite false-negative vitreous biopsies, in the setting of previous vitreoretinal surgery, the case reveals vitreous opacities, decreased visual acuity, and retinal neovascularization as critical signs in ocular amyloidosis. Conclusions: Here we present the signs and symptoms that raise suspicion for vitreous amyloidosis and how to approach diagnosis early in the disease presentation.<\/jats:p>","DOI":"10.1177\/24741264221079718","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T01:59:31Z","timestamp":1660010371000},"page":"405-408","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrolenticular Vitreous Opacities as a Diagnostic Indicator of Systemic Amyloidosis"],"prefix":"10.1177","volume":"6","author":[{"given":"Chiya","family":"Abramowitz","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric K.","family":"Chin","sequence":"additional","affiliation":[{"name":"Retina Consultants of Southern California, Redlands, CA, USA"},{"name":"Loma Linda Eye Institute, Veterans Affairs Hospital, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R. P.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Erie Retinal Surgery Inc, Erie, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"bibr1-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1159\/000096765"},{"key":"bibr2-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-072611-130030"},{"key":"bibr3-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1080\/13506120500107055"},{"key":"bibr4-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfu117"},{"key":"bibr5-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1004(200011)16:5<447::AID-HUMU16>3.0.CO;2-P"},{"key":"bibr6-24741264221079718","doi-asserted-by":"publisher","DOI":"10.6004\/jadpro.2019.10.8.4"},{"key":"bibr7-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018016402"},{"key":"bibr8-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.60.1.41"},{"key":"bibr9-24741264221079718","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1976.03910030494012"},{"key":"bibr10-24741264221079718","unstructured":"Freund KB, Sarraf D, Mieler WF, Yannuzzi L. The Retinal Atlas E-Book. Vol. 7. 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