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Results: A 20-year-old woman with a history of ependymoma presented with painless blurred vision in the right eye after being started on pembrolizumab for a tumor recurrence. Fundoscopy showed a solitary amelanotic choroidal lesion with surrounding subretinal fluid in the affected eye. Ultrasonography showed moderate internal reflectivity and fluid in Tenon capsule consistent with nodular posterior scleritis. After a course of systemic steroids and discontinuation of the pembrolizumab, the choroidal lesion completely resolved. Conclusions: Clinicians should be aware of posterior scleritis as an ocular complication of this class of medications.<\/jats:p>","DOI":"10.1177\/24741264231163396","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T08:46:46Z","timestamp":1681116406000},"page":"348-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pembrolizumab-Induced Nodular Posterior Scleritis"],"prefix":"10.1177","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-9048","authenticated-orcid":false,"given":"Calvin L.","family":"McNelly","sequence":"first","affiliation":[{"name":"University of Alabama Callahan Eye Hospital and Clinics, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar A.","family":"Haider","sequence":"additional","affiliation":[{"name":"University of Alabama Callahan Eye Hospital and Clinics, Birmingham, AL, USA"},{"name":"Retina Consultants of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Wann","sequence":"additional","affiliation":[{"name":"University of Alabama Callahan Eye Hospital and Clinics, Birmingham, AL, USA"},{"name":"Retina Consultants of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason N.","family":"Crosson","sequence":"additional","affiliation":[{"name":"University of Alabama Callahan Eye Hospital and Clinics, Birmingham, AL, USA"},{"name":"Retina Consultants of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John O.","family":"Mason","sequence":"additional","affiliation":[{"name":"University of Alabama Callahan Eye Hospital and Clinics, Birmingham, AL, USA"},{"name":"Retina Consultants of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"bibr1-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-015-0078-9"},{"key":"bibr2-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2020-316970"},{"key":"bibr3-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100652"},{"key":"bibr4-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13327"},{"key":"bibr5-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002119"},{"key":"bibr6-24741264231163396","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158656"},{"key":"bibr7-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80089-8"},{"key":"bibr8-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26960"},{"key":"bibr9-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx225"},{"key":"bibr10-24741264231163396","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00049"},{"key":"bibr11-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1002\/art.39406"},{"key":"bibr12-24741264231163396","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.840385"},{"key":"bibr13-24741264231163396","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90543-2"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264231163396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264231163396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264231163396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:25:34Z","timestamp":1790695534000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264231163396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1177\/24741264231163396"],"URL":"https:\/\/doi.org\/10.1177\/24741264231163396","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]}}}