{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:09Z","timestamp":1790697909865,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100012211","name":"Carle Foundation Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Purpose: To evaluate the impact of combination treatment of antivascular endothelial growth factor (anti-VEGF) intravitreal injections and corticosteroids in patients with choroidal neovascularization (CNV) secondary to presumed ocular histoplasmosis syndrome (POHS). Methods: A retrospective multicenter study was conducted in a cohort from Illinois and Missouri. Patients were identified over an 8-year period, and data were evaluated over a 1-year study window commencing with treatment initiation. Group 1 included patients treated with intravitreal injections of anti-VEGF, and group 2 included those who received intravitreal injections of anti-VEGF and adjuvant corticosteroids. Optical coherence tomography (OCT) measurements and increases in Early Treatment Diabetic Retinopathy Study (ETDRS) letter score were compared between each group. Results: Using the method of last visit carried forward, the visual acuity (VA) in group 2 was 6.42 ETDRS letters better than the VA in group 1 at the final assessment. Patients in group 2 had a mean ETDRS letter gain of 21.50 ( P\u2009=\u2009.06) from the initial baseline vision. The average amount of decrease in OCT central subfield thickness compared with baseline was lower in group 1 (80.9\u2009\u00b1\u2009129.8 \u00b5m) vs group 2 (102.8\u2009\u00b1\u200990.40 \u00b5m) at the 1-year follow-up visit ( P\u2009=\u2009.25). Conclusions: Approved treatment of CNV secondary to POHS is limited. Adjuvant corticosteroid treatment in patients with CNV secondary to POHS may provide better long-term vision and OCT outcomes than anti-VEGF alone and may offer an additional therapy option for these patients.<\/jats:p>","DOI":"10.1177\/24741264231201778","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:37:23Z","timestamp":1697085443000},"page":"510-520","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Use of Adjunctive Corticosteroid With Antivascular Endothelial Growth Factor Agents in the Treatment of Choroidal Neovascular Membrane Associated With Presumed Ocular Histoplasmosis"],"prefix":"10.1177","volume":"7","author":[{"given":"Leanne T.","family":"Labriola","sequence":"first","affiliation":[{"name":"Southwest Pennsylvania Eye Center Washington, PA, USA"},{"name":"Sewickley Eye Group, Sewickley, PA, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen Campbell","family":"Garwood","sequence":"additional","affiliation":[{"name":"Saint Joseph\u2019s University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Blinder","sequence":"additional","affiliation":[{"name":"The Retina Institute, Saint Louis, MO, 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