{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:57Z","timestamp":1790697897976,"version":"4.1.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Purpose: To determine the time-based incidence of total blindness after central retinal artery occlusion (CRAO) with secondary ocular neovascularization (ONV). Methods: In this retrospective cohort study, electronic records were queried using ICD-9 and ICD-10 codes to identify patients with secondary ONV post-CRAO. Patients with possible alternative ONV etiologies, previous panretinal photocoagulation (PRP), and\/or previous antivascular endothelial growth factor (anti-VEGF) therapy were excluded. Clinical data included demographics, medical comorbidities, ONV manifestations, medical\/surgical management, and best-corrected visual acuity (BCVA). Kaplan-Meier analysis was performed with total blindness (defined as a BCVA of no light perception) as the outcome of interest. Results: Of 345 eyes with CRAO, 34 met the inclusion criteria with a mean (\u00b1SD) follow-up of 22.0\u2009\u00b1\u200926.2 months. ONV management included PRP (70.6%), glaucoma drainage implant surgery or transscleral cyclophotocoagulation (32.4%), and intravitreal anti-VEGF therapy (mean 2.8\u2009\u00b1\u20095.6 injections per patient). The cumulative incidence of total blindness was 49.4% (95% confidence interval, 27.2%-71.6%) at 24 months, with 53.3% of cases occurring within 4 months of ONV onset. Conclusions: Post-CRAO ONV is associated with a high risk for progression from severe vision loss to total blindness. Neovascular glaucoma can present up to 4 months after CRAO, challenging the paradigm of \u201c30-day-glaucoma.\u201d Routine gonioscopy should extend through this period, while glaucoma surgery can delay further vision loss. These findings can be used to counsel patients on the importance of follow-up adherence.<\/jats:p>","DOI":"10.1177\/24741264231213169","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T05:31:00Z","timestamp":1701149460000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of Total Blindness After Central Retinal Artery Occlusion With Ocular Neovascularization"],"prefix":"10.1177","volume":"8","author":[{"given":"Harshvardhan","family":"Chawla","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley J.","family":"Redrick","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Pannell","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-0733","authenticated-orcid":false,"given":"Nathaniel P.","family":"Goldblatt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Louisiana State University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Anthony","family":"Mazzulla","sequence":"additional","affiliation":[{"name":"Division of Vitreoretinal Surgery, Department of Ophthalmology, Ochsner Medical Center, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Benevento","sequence":"additional","affiliation":[{"name":"Division of Vitreoretinal Surgery, Department of Ophthalmology, Ochsner Medical Center, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth","family":"Puri","sequence":"additional","affiliation":[{"name":"Division of Vitreoretinal Surgery, Department of Ophthalmology, Ochsner Medical Center, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"bibr1-24741264231213169","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.005"},{"key":"bibr2-24741264231213169","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.25"},{"key":"bibr3-24741264231213169","doi-asserted-by":"publisher","DOI":"10.3928\/15428877-20061101-12"},{"key":"bibr4-24741264231213169","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.03.006"},{"key":"bibr5-24741264231213169","unstructured":"Kattah JC, Wang DZ, Reddy C. Intravenous recombinant tissue-type plasminogen activator thrombolysis in treatment of central retinal artery occlusion. 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