{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:56Z","timestamp":1790697956455,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY011373P30"],"award-info":[{"award-number":["P30 EY011373P30"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Purpose: To present a series of 4 patients from the Ohio Amish or Mennonite populations with isolated ectopia lentis. Methods: A case series was evaluated. Results: Four cases with bilateral lens subluxations were diagnosed with a homozygous c.767_786del pathogenic variant in ADAMTSL4. Their ages ranged from 2 to 22 years. Three cases were symptomatic and were managed surgically with lensectomy, vitrectomy, and endolaser photocoagulation with or without secondary intraocular lens (IOL) implantation. One asymptomatic patient was observed. The postoperative visual acuity ranged from 20\/20 to 20\/60 in nonamblyopic eyes. Conclusions: The pathogenic homozygous c.767_786del variant in ADAMTSL4 may be a cause of bilateral isolated ectopia lentis in the Ohio Amish and Mennonite populations, likely as a result of a founder effect. Vitrectomy and lens extraction with or without secondary IOL implantation may lead to good visual outcomes. There were no cases of retinal detachment.<\/jats:p>","DOI":"10.1177\/24741264241249024","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T07:25:59Z","timestamp":1714375559000},"page":"442-451","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Autosomal Recessive\n                    <i>ADAMTSL4<\/i>\n                    -Related Isolated Ectopia Lentis in the Ohio Old Order Amish and Mennonite Communities"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-135X","authenticated-orcid":false,"given":"TsunKang","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Case Western Reserve University School of Medicine, University Hospitals Eye Institute, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kloosterboer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Case Western Reserve University School of Medicine, University Hospitals Eye Institute, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"\u00d6rge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Case Western Reserve University School of Medicine, University Hospitals Eye Institute, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Sobol","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Case Western Reserve University School of Medicine, University Hospitals Eye Institute, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J.","family":"Echegaray","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Case Western Reserve University School of Medicine, University Hospitals Eye Institute, Cleveland, OH, USA"},{"name":"Retina Consultants of Orlando, LLC, Altamonte Springs, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"bibr1-24741264241249024","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2013.825276"},{"key":"bibr2-24741264241249024","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5955"},{"key":"bibr3-24741264241249024","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18041551"},{"key":"bibr4-24741264241249024","doi-asserted-by":"publisher","DOI":"10.1007\/s10943-022-01615-4"},{"key":"bibr5-24741264241249024","unstructured":"Young Center for Anabaptist and Pietist Studies EC. 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