{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:25Z","timestamp":1790697865526,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Purpose: To present a case of central retinal artery occlusion (CRAO) leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) within 1 week of an adenovirus vector COVID-19 vaccination. Methods: A case was reviewed. Results: A 50-year-old man with atopic dermatitis and asthma presented with acute painless vision loss in 1 eye. An examination and imaging findings showed CRAO. Further evaluation found eosinophilia and elevated inflammatory markers. A workup for vasculitis showed elevated cytoplasmic-antineutrophil cytoplasmic antibody, perinuclear-antineutrophil cytoplasmic antibody, myeloperoxidase antibody, rheumatoid factor, and total immunoglobulin E. Skin biopsies were consistent with eosinophilic granulomatosis with polyangiitis. Steroids, cyclophosphamide, and mepolizumab were initiated. At 1 year, the patient\u2019s systemic symptoms had improved but his vision had not. Conclusions: Few reports exist of CRAO associated with eosinophilic granulomatosis with polyangiitis, with no other instances related to an adenovirus vector COVID-19 vaccination. Treating a systemic vasculitis early can be vision saving in the fellow eye and prevent systemic life-threatening complications.<\/jats:p>","DOI":"10.1177\/24741264241252588","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T06:56:59Z","timestamp":1718002619000},"page":"471-475","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Central Retinal Artery Occlusion Leading to Diagnosis of Eosinophilic Granulomatous Polyangiitis After Adenovirus Vector COVID-19 Vaccination"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-0795","authenticated-orcid":false,"given":"Mary M.","family":"Moses","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"},{"name":"Retina Consultants of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"},{"name":"Retina Consultants of Alabama, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"Elston","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dib","sequence":"additional","affiliation":[{"name":"Kremer Eye Center, King of Prussia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"bibr1-24741264241252588","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.galenos.2020.95852"},{"key":"bibr2-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1007\/s40135-017-0135-2"},{"key":"bibr3-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2020.100683"},{"key":"bibr4-24741264241252588","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S34195"},{"key":"bibr5-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1016\/s0161-6420(01)00557-7"},{"key":"bibr6-24741264241252588","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.112164"},{"key":"bibr7-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-022-05707-5"},{"key":"bibr8-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101430."},{"key":"bibr9-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2023.0610"},{"key":"bibr10-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2104882"},{"key":"bibr11-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.06.016"},{"key":"bibr12-24741264241252588","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050435"},{"key":"bibr13-24741264241252588","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10010013"},{"key":"bibr14-24741264241252588","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.21176"},{"key":"bibr15-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13443"},{"key":"bibr16-24741264241252588","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10050716"},{"key":"bibr17-24741264241252588","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcab273"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264241252588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264241252588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264241252588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:26Z","timestamp":1790695466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264241252588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/24741264241252588"],"URL":"https:\/\/doi.org\/10.1177\/24741264241252588","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]}}}