{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:05:32Z","timestamp":1790697932141,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Purpose: To describe the use of intra-arterial tissue plasminogen activator (tPA) to treat central retinal artery occlusion (CRAO). Methods: A case and its findings were analyzed. Results: A 45-year-old man diagnosed with a CRAO and had cerebral angiography and treatment with intra-arterial tPA. After treatment, follow-up included optical coherence tomography (OCT), fundus photography, fluorescein angiography, and OCT angiography. The visual acuity (VA) improved from hand motions to 20\/30 immediately after fibrinolysis. A vascular occlusion event the next day resulted in a decrease in VA to 20\/400. After initiation of dual antiplatelet therapy, the patient\u2019s VA improved to 20\/20. As the retina recovered, the evolution of retinal ischemic changes to a finding similar to paracentral acute middle maculopathy was seen on imaging. Conclusions: This is the first report describing a patient safely started on dual antiplatelet therapy that led to vision improvement after initial treatment with intra-arterial tPA for a CRAO resulted in recurrent vision loss.<\/jats:p>","DOI":"10.1177\/24741264241267376","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:42:46Z","timestamp":1723102966000},"page":"622-626","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Treatment of Central Retinal Artery Occlusion With Tissue Plasminogen Activator Followed by Recurrent Retinal Ischemia"],"prefix":"10.1177","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-7214","authenticated-orcid":false,"given":"Jerry","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mallick","sequence":"additional","affiliation":[{"name":"Retina Center of New Jersey, North Bergen, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reade","family":"De Leacy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin N.","family":"Ginsburg","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth M.C.","family":"Lema","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"bibr1-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.061"},{"key":"bibr2-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505404"},{"key":"bibr3-24741264241267376","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S272126"},{"key":"bibr4-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-022-05797-1"},{"key":"bibr5-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000366"},{"key":"bibr6-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1136\/bmjophth-2018-000187"},{"key":"bibr7-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001033"},{"key":"bibr8-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.07.030"},{"key":"bibr9-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-023-00475-8"},{"key":"bibr10-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22411"},{"key":"bibr11-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"bibr12-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0768-4"},{"key":"bibr13-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-012-0202-9"},{"key":"bibr14-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.06.016"},{"key":"bibr15-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.613653"},{"key":"bibr16-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10838-6"},{"key":"bibr17-24741264241267376","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2013.15.3.182"},{"key":"bibr18-24741264241267376","doi-asserted-by":"publisher","DOI":"10.7461\/jcen.2020.22.1.1"},{"key":"bibr19-24741264241267376","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.048"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264241267376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264241267376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264241267376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:25:45Z","timestamp":1790695545000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264241267376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/24741264241267376"],"URL":"https:\/\/doi.org\/10.1177\/24741264241267376","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]}}}