{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T00:52:40Z","timestamp":1794185560557,"version":"4.8.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To present the first real-world safety data describing the clinical experience of geographic atrophy (GA) treatment with avacincaptad pegol in a large cohort.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A retrospective, observational cohort study was conducted within the PRISM Vision Group by filtering for J-codes for avacincaptad pegol from August 3, 2023, to October 10, 2024.\n                    <jats:bold>Results:<\/jats:bold>\n                    The study included 461 eyes of 335 patients with GA who were treated with intravitreal avacincaptad pegol 2 mg (0.1 mL of 20 mg\/mL) injections. The mean follow-up time was 120 days. The mean injection interval was 52 days. Fourteen eyes (3%) developed an acute rise in intraocular pressure, and there were no reports of endophthalmitis, intraocular inflammation, or nonarteritic anterior ischemic optic neuropathy. Eight eyes (2.03%) converted to neovascular age-related macular degeneration, with an average of 2 injections before conversion and a predicted annualized rate of conversion of approximately 6.17%. One eye (0.2%) developed a vitreous hemorrhage.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This study describes the real-world safety profile of avacincaptad pegol that may aid clinicians in understanding the risk of adverse events associated with this relatively new treatment for GA.\n                  <\/jats:p>","DOI":"10.1177\/24741264251367100","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T14:05:07Z","timestamp":1756908307000},"page":"784-787","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Real-World Experience of Geographic Atrophy Treatment With Avacincaptad Pegol"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7810-8760","authenticated-orcid":false,"given":"Abdullah","family":"Abou-Samra","sequence":"first","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"},{"name":"Department of Ophthalmology, Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7605-7715","authenticated-orcid":false,"given":"Muhi Dean","family":"Barazi","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"},{"name":"Department of Biosciences, Rice University, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8951-6224","authenticated-orcid":false,"given":"Amira","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3443-329X","authenticated-orcid":false,"given":"Omar","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Bade","sequence":"additional","affiliation":[{"name":"School of Medicine, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-6899","authenticated-orcid":false,"given":"Brian K.","family":"Do","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-5660","authenticated-orcid":false,"given":"Jeanette","family":"Du","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"},{"name":"Department of Ophthalmology, Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Ebert","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"},{"name":"Department of Ophthalmology, Georgetown University School of Medicine, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-3823","authenticated-orcid":false,"given":"Jordana","family":"Fein","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Levinson","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Melamud","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Retina Group of Washington, Reston, VA, 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