{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:13Z","timestamp":1790697853787,"version":"4.1.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To compare long-term visual outcomes in patients with neovascular age-related macular degeneration (AMD) who\nreceived frequent vs infrequent antivascular endothelial growth factor injections.\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective case series included treatment-na\u00efve patients with AMD receiving either frequent injections (\u2264 6-week intervals) or infrequent injections (\u2265 10-week intervals). Best-available visual acuity (VA) and anatomic outcomes were assessed at the initial visit, 52 weeks, 104 weeks, and final visit.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 151 eyes were studied over a mean follow-up of 42.6 months: 81 eyes (54%) in the frequent group and 70 eyes (46%) in the infrequent group. Baseline central foveal thickness (CFT) was higher in the frequent group (320 \u00b5m vs 265 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .002). Though CFT improved in both groups, it remained higher in the frequent group at 52 weeks (230 \u00b5m vs 185 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .004), 104 weeks (203 \u00b5m vs 173 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .004), and final visit (197 \u00b5m vs 165 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .015). The frequent group showed more subretinal and intraretinal fluid at all times. Baseline logMAR VA was 0.63 and 0.84 in the frequent and infrequent groups, respectively\n                    <jats:italic toggle=\"yes\">(P<\/jats:italic>\n                    = .10). Visual improvement was similar between groups at 52 weeks (0.21 vs 0.22 logMAR;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .916), 104 weeks (0.21 vs 0.18 logMAR;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .714), and final visit (0.1 vs 0.05 logMAR;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .510). Poor baseline VA (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) and geographic atrophy (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .025) were associated with worse outcomes.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Over 4 years, despite higher CFT and more fluid, frequent injections showed similar visual improvement to infrequent injections. Baseline vision was the strongest predictor of final outcomes, regardless of injection frequency.\n                  <\/jats:p>","DOI":"10.1177\/24741264251371007","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T09:44:58Z","timestamp":1758015898000},"page":"792-799","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Characteristics and Long-Term Outcomes of Eyes With Neovascular Age-Related Macular Degeneration Requiring Frequent Treatment"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-2876","authenticated-orcid":false,"given":"Mirataollah","family":"Salabati","sequence":"first","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Garrigan","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-7369","authenticated-orcid":false,"given":"Bita","family":"Momenaei","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-6079","authenticated-orcid":false,"given":"Taku","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Chiang","family":"Wong","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, Department of Ophthalmology, New York Medical College, Valhalla, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillan","family":"Patel","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-9083","authenticated-orcid":false,"given":"Raziyeh","family":"Mahmoudzadeh","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-3429","authenticated-orcid":false,"given":"Hana A.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ammar","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Xu","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Regillo","sequence":"additional","affiliation":[{"name":"Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.07.038"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.09.030"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.208"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.10.018"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.12.016"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.03.046"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.09.012"},{"key":"e_1_3_2_11_2","volume-title":"ASRS 2019 Preferences and Trends Membership Survey","author":"Stone TW","year":"2019","unstructured":"Stone TW, Hahn P, eds. ASRS 2019 Preferences and Trends Membership Survey. American Society of Retina Specialists; 2019."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2016.12.004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.08.009"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.09.018"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.6776"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.08.023"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.07.014"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.01.013"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.033"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.01.073"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.03.053"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta19780"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.05.010"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.11.031"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2016.227"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/2474126419834702"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.009"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.011"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.03.045"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.11.017"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.12.002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.12.029"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001736"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001613"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.11.025"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1159\/000443209"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3588-y"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2019.09.016"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2020.43435"}],"container-title":["Journal of VitreoRetinal Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264251371007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/24741264251371007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/24741264251371007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:24:26Z","timestamp":1790695466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/24741264251371007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/24741264251371007"],"URL":"https:\/\/doi.org\/10.1177\/24741264251371007","relation":{},"ISSN":["2474-1264","2474-1272"],"issn-type":[{"value":"2474-1264","type":"print"},{"value":"2474-1272","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,16]]}}}