{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:03:53Z","timestamp":1790697833539,"version":"4.1.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To evaluate the real-world safety and efficacy of the 0.19 mg fluocinolone acetonide intravitreal implant for the management of diabetic macular edema (DME).\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective study included 94 eyes from 58 patients, of whom all but 1 had type 2 diabetes. The mean age (\u00b1 SD) was 75.5 \u00b1 2.12 years. Each patient received at least 1 fluocinolone acetonide implant after a corticosteroid trial without significant intraocular pressure elevation. Data were collected from visits up to 18 months preimplantation (mean, 14.6 months) and 3 years postimplantation (mean, 51 months). Key outcomes included central subfield thickness (CST), visual acuity (VA), intraocular pressure, retinal thickness variability measures, and treatment frequency.\n                    <jats:bold>Results:<\/jats:bold>\n                    Mean baseline VA remained stable, decreasing from 61.5 \u00b1 1.5 Early Treatment Diabetic Retinopathy Study (ETDRS) letters preimplantation to 58.2 \u00b1 0.3 ETDRS letters postimplantation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .034). Mean CST decreased significantly from 427.6 \u00b1 20.8 \u00b5m 1 month preimplantation to 310.6 \u00b1 11.4 \u00b5m at final follow-up (\n                    <jats:italic toggle=\"yes\">P &lt;<\/jats:italic>\n                    .001). Annual treatment frequency dropped significantly from 4.6 \u00b1 0.95 injections preimplantation to 2.3 \u00b1 0.25 injections postimplantation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .021). Retinal thickness variability improved significantly (80.4 \u00b1 5.8 \u00b5m to 63.8 \u00b1 4.6 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .027), with a corresponding CST area under the curve (351.1 \u00b1 13.5 \u00b5m\u00b2 to 296.7 \u00b1 10.9 \u00b5m\u00b2;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .002). Intraocular pressure remained stable, increasing slightly from 15.8 mmHg to 16.3 mmHg. No new safety signals were observed.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The fluocinolone acetonide implant demonstrated sustained visual stability, significant anatomical improvement, reduced treatment burden, and a manageable safety profile. These findings support its role as an effective long-term therapeutic option for DME, including in vitrectomized eyes.\n                  <\/jats:p>","DOI":"10.1177\/24741264251380717","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:33:24Z","timestamp":1762504404000},"page":"90-97","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Real-World Clinical Outcomes After Sustained Delivery of the 0.19 mg Fluocinolone Acetonide Implant for Treatment of Diabetic Macular Edema"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6101-441X","authenticated-orcid":false,"given":"Sarah","family":"Godel","sequence":"first","affiliation":[{"name":"University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damla","family":"Oncel","sequence":"additional","affiliation":[{"name":"Loyola Stritch School of Medicine, Maywood, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-5380","authenticated-orcid":false,"given":"Richard","family":"Donkor","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine, Bascom Palmer Eye Institute, Palm Beach Gardens, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-2637","authenticated-orcid":false,"given":"Joseph M.","family":"Coney","sequence":"additional","affiliation":[{"name":"Retina Associates of Cleveland Inc, Cleveland, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2022.0052"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.03.010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.10.030"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.08.016"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.03.045"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-018-0145-7"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0905"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S214098"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2018-0006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.12.028"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.04.030"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2022.01.015"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e3181d87e04"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.9.4.334"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.02.022"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/632307"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2018.6786"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S79785"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S105385"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2022.09.017"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2017.125"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.02.034"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e318206d18c"}],"container-title":["Journal 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