{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:58:52Z","timestamp":1791248332126,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To characterize real-world use of intravitreal aflibercept 8 mg across 22 US retina practices.\n                    <jats:bold>Methods:<\/jats:bold>\n                    A retrospective review was performed of patients who received at least 1 intravitreal aflibercept 8 mg injection for treatment of neovascular age-related macular degeneration, diabetic macular edema, or diabetic retinopathy through April 1, 2024. Data from health records were collected retrospectively, including best-corrected visual acuity (BCVA), interval between treatments, and adverse events.\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 8323 eyes of 6271 patients received 20 385 intravitreal aflibercept 8 mg injections. A total of 669 eyes (8.0%) were not previously treated. Among treatment-naive eyes, mean logMAR BCVA improved from 0.57 (Snellen equivalent ~20\/80) at the time of the first intravitreal aflibercept 8 mg injection, to 0.47 (Snellen equivalent ~20\/60) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), 0.46 (Snellen equivalent ~20\/60) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and 0.48 (Snellen equivalent ~20\/60) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .012) at the second, third, and fourth intravitreal aflibercept 8 mg injections, respectively. Among previously treated eyes, mean logMAR BCVA improved from 0.46 (Snellen equivalent ~20\/60) at the time of the first intravitreal aflibercept 8 mg injection, to 0.42 (Snellen equivalent ~20\/50) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), 0.43 (Snellen equivalent ~20\/50) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and 0.45 (Snellen equivalent ~20\/60) (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .70) at the second, third, and fourth intravitreal aflibercept 8 mg injections, respectively. Treatment intervals to time of second, third, and fourth intravitreal aflibercept 8 mg injections increased compared with baseline intervals, by a mean of 2.2 days (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), 2.5 days (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and 13.5 days (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), respectively. Intraocular inflammation was observed in 11 eyes (1 in 1853 injections). Nine eyes (1 in 2265 injections) developed suspected endophthalmitis.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    In this real-world clinical setting, intravitreal aflibercept 8 mg treatment demonstrated improvements in BCVA outcomes, with increased intervals between injections. Rates of intraocular inflammation and endophthalmitis were low.\n                  <\/jats:p>","DOI":"10.1177\/24741264251383384","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:53:50Z","timestamp":1760838830000},"page":"20-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["The Efficacy and Safety of Intravitreal Aflibercept 8 mg in Clinical Practice"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8702-8043","authenticated-orcid":false,"given":"Brandon A.","family":"Bates","sequence":"first","affiliation":[{"name":"Austin Retina Associates, University of Texas Dell Medical School, Austin, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-3429","authenticated-orcid":false,"given":"Hana A.","family":"Mansour","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasenin","family":"Al-khersan","sequence":"additional","affiliation":[{"name":"Retina Consultants of Texas, Houston, TX, USA"},{"name":"Retina Consultants of America, Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Wood","sequence":"additional","affiliation":[{"name":"Austin Retina Associates, University of Texas Dell Medical School, Austin, TX, USA"},{"name":"Retina Consultants of America, Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-7369","authenticated-orcid":false,"given":"Bita","family":"Momenaei","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Schneider","sequence":"additional","affiliation":[{"name":"Tennessee Retina, Nashville, TN, USA"},{"name":"Retina Consultants of America, Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collin J.","family":"Richards","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeYoung","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Wykoff","sequence":"additional","affiliation":[{"name":"Retina Consultants of Texas, Houston, TX, USA"},{"name":"Retina Consultants of America, Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Quinn","sequence":"additional","affiliation":[{"name":"Retina Consultants of America, Fort Worth, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-4219","authenticated-orcid":false,"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Regillo","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Ho","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Fineman","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Klufas","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2137-7387","authenticated-orcid":false,"given":"Philip P.","family":"Storey","sequence":"additional","affiliation":[{"name":"Austin Retina Associates, University of Texas Dell Medical School, Austin, TX, USA"},{"name":"Retina Consultants of America, Fort Worth, TX, 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