{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T21:41:15Z","timestamp":1794433275575,"version":"4.9.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"J. Arch McNamara, MD Fund for Retina Research and Education"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose.<\/jats:bold>\n                    To determine short-term changes in intraocular pressure (IOP) after intravitreal injection of 0.1 mL pegcetacoplan (Syfovre; Apellis Pharmaceuticals) for the treatment of geographic atrophy (GA).\n                    <jats:bold>Methods.<\/jats:bold>\n                    This prospective, interventional study evaluated a case series of patients with GA without corneal pathology or a history of vitreoretinal surgery who received pegcetacoplan injections. IOP was measured with a handheld applanation tonometer immediately prior to injection, immediately after injection, and at 5, 10, 20, and 30 minutes postinjection.\n                    <jats:bold>Results.<\/jats:bold>\n                    Fifty-one patients (total 73 eyes) were enrolled. The mean (\u00b1SD) preinjection IOP was 15.3 \u00b1 3.3 mm Hg, which significantly increased to 40.2 \u00b1 13.7 mm Hg (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001) immediately after injection. Subsequent IOP measurements showed a gradual decrease to 31.3 \u00b1 11.6 mm Hg at 5 minutes (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), 23.2 \u00b1 9.7 mm Hg at 10 minutes (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), 19.6 \u00b1 8.6 mm Hg at 20 minutes (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and 16.4 \u00b1 4.9 mm Hg at 30 minutes (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .05) postinjection. No further treatment was required, except that the left eye of 1 patient with a history of primary open-angle glaucoma and persistent IOP elevation underwent anterior chamber tap 20 minutes after injection. Multivariate linear regression analysis revealed that a higher IOP at 30 minutes postinjection was significantly associated with the preinjection IOP (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .004) and with a history of glaucoma (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .019).\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    Following pegcetacoplan injections, immediate IOP elevation was observed, which gradually declined within the first 30 minutes. Eyes with higher baseline IOP or a history of glaucoma exhibited higher postinjection IOP.\n                  <\/jats:p>","DOI":"10.1177\/24741264251390791","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:04:51Z","timestamp":1763139891000},"page":"211-216","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Short-Term Changes in Intraocular Pressure Following Intravitreal Injection of Pegcetacoplan"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-7369","authenticated-orcid":false,"given":"Bita","family":"Momenaei","sequence":"first","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-6079","authenticated-orcid":false,"given":"Taku","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufemi E.","family":"Adams","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7951-6838","authenticated-orcid":false,"given":"Kristine","family":"Wang","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl D.","family":"Regillo","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Spirn","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Ho","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[{"name":"Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Wills Eye 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