{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:04:21Z","timestamp":1790697861454,"version":"4.1.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"J. Arch McNamara, MD Fund for Retina Research and Education, Philadelphia, PA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of VitreoRetinal Diseases"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To determine the outcomes of physician-directed pausing of antivascular endothelial growth factor (anti-VEGF) injections in eyes with branch retinal vein occlusion (BRVO).\n                    <jats:bold>Methods:<\/jats:bold>\n                    This retrospective review investigated eyes of patients with BRVO-associated macular edema that received \u22653 anti-VEGF injections within the first 6 months of diagnosis, followed by a \u22656-month physician-directed treatment pause, with \u22651 year of follow-up, between January 1, 2015, and December 1, 2022. The rate and timing of treatment reinitiation, as well as associated changes in visual acuity (VA) and optical coherence tomography (OCT) characteristics, were evaluated.\n                    <jats:bold>Results:<\/jats:bold>\n                    Of 402 eyes that received a mean of 9 injections over a mean of 14.3 months before treatment suspension, 253 (62.9%) did not need further treatment for a mean of 35.5 months. Mean VA at time of pause (0.35 logMAR [Snellen 20\/45]) stayed stable at 1 year (0.38 logMAR [Snellen 20\/48];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .113) but worsened slightly by the final visit (0.4 logMAR [Snellen 20\/50];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .011). Mean central foveal thickness at time of pause (215 \u00b5m) remained stable at 1 year (209 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .961) and at final visit (217 \u00b5m;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .466). For the remaining 37.1% of eyes, treatment was resumed after a mean of 17.7 months. Longer last-injection intervals (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .010), residual fluid at time of pause (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001), and shorter time from edema diagnosis to first injection (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .049) were associated with resumption.\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : In most patients with BRVO who had a physician-directed pause of anti-VEGF therapy due to disease inactivity, the VA and OCT metrics remained stable for almost 3 years. However, more than one-third of eyes required additional injections, highlighting the importance of continued follow-up after treatment cessation.\n                  <\/jats:p>","DOI":"10.1177\/24741264261418590","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:13:03Z","timestamp":1771503183000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes After a Physician-Directed Pause of Antivascular Endothelial Growth Factor Therapy in Eyes With Branch Retinal Vein Occlusion"],"prefix":"10.1177","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5435-7369","authenticated-orcid":false,"given":"Bita","family":"Momenaei","sequence":"first","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawson C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Shah","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-1006","authenticated-orcid":false,"given":"Allen","family":"Chiang","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl H.","family":"Park","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S.","family":"Fineman","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Vander","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-4219","authenticated-orcid":false,"given":"Jason","family":"Hsu","sequence":"additional","affiliation":[{"name":"The Retina Service of Wills Eye Hospital, Wills Eye Physicians-Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.1980.tb00340.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082360"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-022-01960-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003118"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000003616"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-015-0412-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.01.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2022-323120"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.6843"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.06.011"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2024.04.014"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2023.08.005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.08.038"}],"container-title":["Journal 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